Chronic (-)-epicatechin administration does not affect contracting skeletal muscle microvascular oxygenation

作者

Clark Holdsworth¹ , Steven Copp¹ , Tadakatsu Inagaki¹ , Daniel Hirai¹ , Scott Ferguson¹ , Gabrielle Sims¹ , Michael White¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

会议/活动

Integrative Biology of Exercise, October 2012 (Westminster, CO, United States)

海报摘要

The flavanol -(-)epicatechin (EPI) is a naturally occurring component of cocoa, consumption of which is associated with numerous cardiovascular health benefits. Chronic EPI reportedly augments mouse skeletal muscle capillarity and mitochondrial density (Nogueira et al, J Physiol, 589, 2011). These effects may translate to improved skeletal muscle O2 delivery-utilization matching (i.e. ↑ microvascular O2 pressure (PO2mv)) during contractions. We tested the hypothesis that EPI would elevate PO2mv at rest and contractions. Rats were administered EPI (2mg/kg , n=5) or water (CON; n=5) via oral gavage twice daily for 21 days. PO2mv was measured via phosphorescence quenching in the spinotrapezius muscle at rest and during 180 s of 1 Hz twitch contractions. Despite previous reports of the efficacy of EPI to improve the O2 transport pathway,chronic EPI treatment (2mg/kg) does not improve skeletal muscle microvascular oxygenation at rest or during contractions.

关键词

microcirculation, oxygen diffusion, vascular control

研究领域

Anatomy and Physiology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.