Notice of Special Interest: Epidemiology and Prevention in Alcohol Research

NOT-AA-20-017

Advancing knowledge about the epidemiology of alcohol use is fundamental to improving the public health. One prominent objective is to better understand the developmental trajectories of alcohol use, risky drinking, and alcohol use disorders. We know that people who initiate alcohol use at younger ages are more likely to develop alcohol use disorders. However, much is unknown about the train of events between early initiation, frequent heavy drinking, and the development of an alcohol use disorder. Much is also unknown about how the various risk factors in this train of events interact with each other. Genetics certainly plays a role. However, the ways in which epigenetic changes in gene expression are produced by interactions with environmental influences are only beginning to be understood. Similarly, little is known about the correlates of "maturing out" of heavy drinking, which happens in most individuals, but not all. Keywords Alcoholism Prevention Alcohol or Alcoholism Epidemiology Epigenetics Upcoming Deadlines NoteSubmit applications for this initiative using one of the following funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.PA-19-055PA-19-056PA-19-091PA-20-185PA-20-184PA-20-183PA-20-200PA-20-194PA-20-195PA-20-196 Recurrence of Opportunity:This is a one-off opportunity. We do not expect future rounds.