This review provides a comprehensive overview of the mechanical challenges related to microneedle (MN) usage, an increasingly important tool for minimally invasive drug delivery.
The review article highlights the promising future of microneedle technology in vaccine delivery. Fueled by the SARS-CoV-2 pandemic, the development of this painless, user-friendly vaccination method is evolving.
"Crime as a service" refers to the practice of offering criminal services or tools as a commercialized and easily accessible service on the internet. This includes hacking, malware distribution, selling stolen data, and even dark web.
This review discusses the potential of electroceuticals for peripheral nerve regeneration, highlighting the challenges in delivering effective and controllable electroceuticals via bioelectronic implantable devices.
Very useful article published in BMJ Global Health. The study provides a comprehensive review of Living Systematic Reviews (LSRs) up to October 2021 using bibliometrics. LSRs have gained significant attention, with a growing number of studies conducted since 2020, especially in Europe, North America, and Australia. COVID-19 is the predominant focus of LSRs, and potential future research directions include rehabilitation of COVID-19 patients and virological studies.
Researchers developed stable gelatin-collagen matrices using two-photon polymerization with incorporated ruthenium complexes as photo-activators. These matrices allowed continuous monitoring of local oxygen levels (pO2) at the pericellular level in 3D cell cultures. The study demonstrated the potential for analyzing cancer cell metabolic adaptations and migration in a more in vivo-like microenvironment, offering new therapeutic insights and drug screening platforms.
This review article highlights nine highly effective and key herbs, with unique molecular mechanisms of action, to be used alongside antibiotics in overcoming the crisis of antibiotic resistance.
These findings add valuable information to our understanding of the potential bioactive compounds present in Leonurus japonicus Houtt. They also shed light on how these compounds may influence hepatoprotection and cytotoxicity.
Interesting seminar. These interactive resources provide an excellent opportunity for educators to create engaging and interactive assignments for their students.
For medical imaging, ensuring model accuracy and safety is of paramount significance, making thorough preparation and evaluation indispensable steps in the machine learning process.
Published in JCB, the study demonstrated the functional significance of Kinesin-1 autoinhibition in dynein-mediated early endosome transport. Kinesin-1 autoinhibition facilitates dynein to initiate early endosome transport, independently of direct competition between dynein and kinesin-1, and is related to cargo adapter-mediated dynein activation beyond the switching of dynein from its autoinhibited conformation.
This study explores the activation of cytoplasmic dynein by its cofactors, dynactin, and coiled-coil cargo adaptors. The researchers used a cryo-electron microscopy processing pipeline to determine the high-resolution structure of dynein-dynactin and the adaptor BICDR1 bound to microtubules, revealing the asymmetric interactions between dynein motor domains and their implications for motor recruitment by cargos in terms of stability and stoichiometry.
Published in JCS, the review article highlights the role of kinetochore dynein in efficient and accurate spindle assembly and delves into the molecular mechanisms and commonalities with dynein regulation at other subcellular locations.
This paper highlights the significant role of serotonin (5-HT) in the development of pulmonary arterial remodeling, a crucial process in pulmonary arterial hypertension (PAH). By directly stimulating pulmonary artery adventitial fibroblasts (PAFs) through the 5-HT2A receptor, 5-HT induces excessive proliferation, migration, and fibrotic activation of PAFs, leading to phenotypic alterations and adventitia fibrosis.
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