The NIH has grown to become one of the world's foremost medical research centers. The institution supports and conducts a wide range of basic, clinical, and translational medical research to help improve health outcomes and reduce the burdens of illness and disability.
Access to cancer care is influenced by a myriad of factors, many of which are deeply rooted in regional, ethnic, religious, socioeconomic, and cultural contexts. These factors often intertwine, creating barriers or facilitating access to care.
Parkinson's Disease: This is perhaps one of the most well-known movement disorders. It is characterized by symptoms such as tremors, bradykinesia (slowness of movement), rigidity, and postural instability. Parkinson's disease results from the loss of dopamine-producing cells in the brain.
This is fascinating. Black Hole Imaging - the Event Horizon Telescope collaboration released the first image of a black hole, providing direct visual evidence of black holes' existence.
The study purified and analyzed human dynein-1 and dynein-2, revealing their motor activities and structures, with dynein-2's activity supporting its role in intraflagellar transport.
Pac1, the yeast equivalent of LIS1, plays a vital role in dynein function and nuclear migration, working with Dyn1 and Bik1 at microtubule plus ends; notably, overexpression of Pac1 boosts cortical dynein activity differently than the loss of its negative regulator, She1.
Dysfunction in ciliary dynein complexes leads to various disorders in mammals called ciliopathies, with different complexes causing distinct health problems ranging from severe skeletal and renal syndromes to respiratory and fertility issues.
How does ethnic identity influence the impact of racial discrimination on anxiety, pain, and suicide ideation among minority adolescents, and what implications does this have for developing strategies to support the mental health of minority youths?
COPD and lung cancer, both linked to cigarette smoke exposure, share genetic and inflammatory factors. Research is needed to explore the molecular connections and identify potential drug targets, particularly in combined models of COPD and lung cancer, to better understand the processes caused by chronic inflammation and genetic alterations.
Selpercatinib (Retevmo) has been approved to treat adults with metastatic RET fusion-positive non–small cell lung cancer, adults and children 12 years and older with advanced or metastatic RET-mutant medullary thyroid cancer, and adults and children 12 years and older with advanced or metastatic RET fusion-positive thyroid cancer who are radioactive iodine-refractory.
Surveillance of lung cancer patients after surgery involves screening for early disease detection, and it's most effective when targeting high-risk groups, such as former smokers identified by studies like the National Lung Screening Trial, which showed that early intervention after CT screening improved cure rates for smaller tumors compared to larger ones. There's no need for additional costly randomized trials; a common-sense approach can apply lessons from smoker screening studies to post-lung cancer patients.
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