期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 5, 期 10, 页码 2221-2230出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201000292
关键词
annularin; bis(oxazoline); carbonylation; kawa lactones; palladium
资金
- [21590026]
Bis(oxazoline)-palladium(II) catalyzed carbonylation of homopropargyl alcohols afforded acyclic methoxyacrylate 2 and 6-membered lactone 3a-k in good combined yield. In the case of propargyl alcohols, 5-membered lactones 3p, 3q, 16 were obtained in moderate yields. The one-pot synthesis of kawa lactones 3a, 3r, 3s and formal synthesis of dihydroxycystothiazole A and dihydroxycystothiazole C are presented. To elucidate the stereochemistry of (+)-annularin C and (-)-annularin H, the first asymmetric syntheses of these natural products were achieved.
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