期刊
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
卷 39, 期 4, 页码 223-227出版社
INFORMA HEALTHCARE
DOI: 10.3109/10731199.2010.533127
关键词
Peripheral nerve; degeneration; regeneration; nerve collateral sprouts
资金
- Chinese National Natural Science Fund for Outstanding Youth [30625036]
- Chinese 973 Project Planning [2005CB522604]
- Chinese National Natural Science Youth Fund [30801169]
- Chinese National Natural Science Fund [30971526]
- Beijing City Science and Technology New Star Classification [A 2008 10]
- Chinese Ministry of Education for Doctor Position New Teacher [20070001780]
- Peking University [RDB2009 01]
The effects of the distal nerve degeneration on the regeneration of the collateral sprouts from the proximal nerve stump have been examined. The delayed cross-suture anastomosis technique was used in which the tibial nerve was denervated for 0-8 weeks before cross-suture of the freshly axotomized common peroneal and chronically denervated TIB nerve stumps. There was a remarkable decreasing of the regenerated myelinated axons number after the distal nerve suffered 8 weeks deterioration, suggesting that short-term denervation did not affect the collateral sprouts regeneration but more prolonged denervation profoundly reduced collateral sprouts regenerated in the distal nerve stump.
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