Ongoing Clinical Trials Evaluating the Cardiovascular Safety and Efficacy of Therapeutic Approaches to Diabetes Mellitus

Research has substantiated that patients with type 2 diabetes mellitus are at increased risk for cardiovascular (CV) disease. It is well established that aggressive management of metabolic risk factors is critical to reducing morbidity and mortality in patients with diabetes. A number of clinical trials are currently focusing on evaluating the safety and efficacy of therapeutic approaches to diabetes. These trials will provide additional information on the role of aggressive management of glucose in patients with diabetes and CV risk. This article provides a summary of these ongoing trials, and discusses the impact of glycemic control and strategies to promote CV risk reduction in patients with diabetes. (C) 2011 Published by Elsevier Inc. (Am J Cardiol 2011;108[suppl]:52B-58B)