Simultaneous Dual Cu/Ir Catalysis: Stereodivergent Synthesis of Chiral β-Lactams with Adjacent Tertiary/Quaternary/Tertiary Stereocenters

Enantioselective Synthesis of Medium-Sized-Ring Lactones via Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reaction

(2022) Lu Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis

(2022) Yu-Hua Wen et al.   Nature Communications

Stereodivergent total synthesis of rocaglaol initiated by synergistic dual-metal-catalyzed asymmetric allylation of benzofuran-3(2H)-one

(2022) Yang Xu et al.   Chem

Bimetallic Catalysis in Stereodivergent Synthesis

(2022) Xiaohong Huo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modular Synthesis of α‐Quaternary Chiral β‐Lactams by a Synergistic Copper/Palladium‐Catalyzed Multicomponent Reaction

(2021) Jialin Qi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis

(2021) Shao-Qian Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantio‐ and Diastereodivergent Synthesis of Spirocycles through Dual‐Metal‐Catalyzed [3+2] Annulation of 2‐Vinyloxiranes with Nucleophilic Dipoles

(2021) Youbin Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergistic Pd/Amine-Catalyzed Stereodivergent Hydroalkylation of 1,3-Dienes with Aldehydes: Reaction Development, Mechanism, and Stereochemical Origins

(2021) Hongfa Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C–H Functionalization/Oxa-Michael Addition Cascade

(2021) Dong-Xing Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines

(2021) Woo-Ok Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Synthesis of Enantioenriched γ‐Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis

(2021) Lu Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Pd/Cu Catalysis for the Dynamic Kinetic Asymmetric Transformation of Racemic Unsymmetrical 1,3-Disubstituted Allyl Acetates

(2020) Rui He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(I)‐Catalyzed Asymmetric Interrupted Kinugasa Reaction: Synthesis of α‐Thiofunctional Chiral β‐Lactams

(2020) Jialin Qi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Carbon–Carbon Bond Formation between Iminium and Enolate Intermediates by Synergistic Organocatalysis

(2020) Byungjun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis

(2020) Zibo Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of α-Alkylidene-β-Lactams through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand

(2019) Koji Imai et al.   ORGANIC LETTERS

Synthesis of Enantioenriched Vicinal Tertiary and Quaternary Carbon Stereogenic Centers Within an Acyclic Chain

(2019) Ilan Marek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions

(2019) Lu-Lu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quaternary-centre-guided synthesis of complex polycyclic terpenes

(2019) Pengfei Hu et al.   NATURE

Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands

(2019) Simon L. Rössler et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stereodivergent Construction of Tertiary Fluorides in Vicinal Stereogenic Pairs by Allylic Substitution with Iridium and Copper Catalysts

(2019) Zhi-Tao He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls

(2019) Mao-Mao Zhang et al.   Nature Communications

Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis

(2019) Qinglong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sequence-Dependent Stereodivergent Allylic Alkylation/Fluorination of Acyclic Ketones

(2019) Xi-Jia Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp 3 )–H Bonds

(2019) Tao Zhou et al.   CHINESE JOURNAL OF CHEMISTRY

Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction

(2019) Shi-Ming Xu et al.   Nature Communications

Asymmetric Synthesis of β-Lactam via Palladium-Catalyzed Enantioselective Intramolecular C(sp3)–H Amidation

(2019) Hua-Rong Tong et al.   ACS Catalysis

Diastereodivergent synthesis of enantioenriched α,β-disubstituted γ-butyrolactones via cooperative N-heterocyclic carbene and Ir catalysis

(2019) Santanu Singha et al.   Nature Catalysis

Asymmetric Synthesis of Spirocyclic β-Lactams through Copper-Catalyzed Kinugasa/Michael Domino Reactions

(2018) Tao Shu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereodivergent Synthesis of α,α-Disubstituted α-Amino Acids via Synergistic Cu/Ir Catalysis

(2018) Liang Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylation of Azaaryl Acetamides and Acetates by Synergistic Iridium and Copper Catalysis

(2018) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters

(2018) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2018) Qiang Cheng et al.   CHEMICAL REVIEWS

Enantioselective α-functionalizations of ketones via allylic substitution of silyl enol ethers

(2018) Zhi-Tao He et al.   Nature Chemistry

Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen’s Amine

(2017) Faben A. Cruz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergence in Asymmetric Catalysis

(2017) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms

(2016) Martin Büschleb et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Diastereoselective and Enantioselective Allylic Substitutions with Acyclic α-Alkoxy Ketones

(2016) Xingyu Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters

(2016) Xing-Ping Zeng et al.   CHEMICAL REVIEWS

F– Nucleophilic-Addition-Induced Allylic Alkylation

(2016) Panpan Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Ir/Zn Dual Catalysis for Enantio- and Diastereodivergent α-Allylation of α-Hydroxyketones

(2016) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Allylic Substitutions with Aryl Acetic Acid Esters by Synergistic Iridium and Lewis Base Catalysis

(2016) Xingyu Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition metal-catalyzed allylic substitution reactions with unactivated allylic substrates

(2015) Nicholas A. Butt et al.   CHEMICAL SOCIETY REVIEWS

A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes

(2015) Tao Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct construction of vicinal all-carbon quaternary stereocenters in natural product synthesis

(2015) Rong Long et al.   NATURAL PRODUCT REPORTS

Enantioselective cis-β-lactam synthesis by intramolecular C–H functionalization from enoldiazoacetamides and derivative donor–acceptor cyclopropenes

(2015) Xinfang Xu et al.   Chemical Science

Side Arm Strategy for Catalyst Design: Modifying Bisoxazolines for Remote Control of Enantioselection and Related

(2014) Saihu Liao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Access to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp3)H Alkylation

(2014) Julia Pedroni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Synthesis of β-Lactams: Asymmetric Catalysis and Other Recent Advances

(2014) Cody Ross Pitts et al.   CHEMICAL REVIEWS

Stereodivergent α-Allylation of Linear Aldehydes with Dual Iridium and Amine Catalysis

(2014) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Asymmetric Synthesis oftrans-β-Lactams by a Kinugasa Reaction on Water

(2013) Zhenling Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diversifying complexity

(2013) Indrajeet Sharma et al.   Nature Chemistry

Enantio- and Diastereodivergent Dual Catalysis:  -Allylation of Branched Aldehydes

(2013) S. Krautwald et al.   SCIENCE

Semipinacol Rearrangement in Natural Product Synthesis

(2011) Zhen-Lei Song et al.   CHEMICAL REVIEWS

Monocyclic β-Lactams: New Structures for New Biological Activities

(2011) P. Galletti et al.   CURRENT MEDICINAL CHEMISTRY

Mechanistically Driven Development of Iridium Catalysts for Asymmetric Allylic Substitution

(2010) John F. Hartwig et al.   ACCOUNTS OF CHEMICAL RESEARCH

Ir-Catalysed Asymmetric Allylic Substitutions with Cyclometalated (Phosphoramidite)Ir Complexes-Resting States, Catalytically Active (π-Allyl)Ir Complexes and Computational Exploration

(2010) Jevgenij A. Raskatov et al.   CHEMISTRY-A EUROPEAN JOURNAL

A palladium-catalysed enolate alkylation cascade for the formation of adjacent quaternary and tertiary stereocentres

(2010) Jan Streuff et al.   Nature Chemistry

Ir-Catalyzed Asymmetric Allylic Substitutions with (Phosphoramidite)Ir Complexes-Resting States, Synthesis, and Characterization of Catalytically Active (π-Allyl)Ir Complexes

(2009) Stephanie Spiess et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Allyl Intermediate in Regioselective and Enantioselective Iridium-Catalyzed Asymmetric Allylic Substitution Reactions

(2009) Sherzod T. Madrahimov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Syntheses of Azetidines and Azetidinones

(2008) Alberto Brandi et al.   CHEMICAL REVIEWS

Chiral N-Heterocyclic Carbene Catalyzed Staudinger Reaction of Ketenes with Imines:  Highly Enantioselective Synthesis ofN-Boc β-Lactams

(2007) Yan-Rong Zhang et al.   ORGANIC LETTERS