Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance

Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell

(2022) Yanmei Hu et al.   JOURNAL OF MEDICAL VIROLOGY

Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties

(2022) Sandeep Lohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Secondary Amine Pendant β-Peptide Polymers Displaying Potent Antibacterial Activity and Promising Therapeutic Potential in Treating MRSA-Induced Wound Infections and Keratitis

(2022) Yuxin Qian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A naturally inspired antibiotic to target multidrug-resistant pathogens

(2022) Zongqiang Wang et al.   NATURE

Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture

(2021) Allison Bakovic et al.   Viruses-Basel

Modular Design of Membrane-Active Antibiotics: From Macromolecular Antimicrobials to Small Scorpionlike Peptidomimetics

(2021) Minghui Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

PEGylation of the Antimicrobial Peptide PG-1: A Link between Propensity for Nanostructuring and Capacity of the Antitrypsin Hydrolytic Ability

(2021) Weikang Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism

(2021) Jiayong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A synthetic antibiotic class overcoming bacterial multidrug resistance

(2021) Matthew J. Mitcheltree et al.   NATURE

Addressing MRSA infection and antibacterial resistance with peptoid polymers

(2021) Jiayang Xie et al.   Nature Communications

Small Molecules with Membrane-Active Antibacterial Activity

(2020) Mi Zhou et al.   ACS Applied Materials & Interfaces

Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides

(2020) Xiaolong Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The application of ceragenins to orthopedic surgery and medicine

(2020) Aiken Dao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Antimicrobial host defence peptides: functions and clinical potential

(2020) Neeloffer Mookherjee et al.   NATURE REVIEWS DRUG DISCOVERY

In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria

(2020) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repurposing Ellipticine Hydrochloride to Combat Colistin-Resistant Extraintestinal Pathogenic E. coli (ExPEC)

(2020) Hao Lu et al.   Frontiers in Microbiology

The activity of sulfono-γ-AApeptide helical foldamers that mimic GLP-1

(2020) Peng Sang et al.   Science Advances

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

(2020) James K. Martin et al.   CELL

Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections

(2020) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual-mechanism antibiotics

(2020) Ursula Theuretzbacher   Nature Microbiology

Sulfono-γ-AApeptides as Helical Mimetics: Crystal Structures and Applications

(2020) Peng Sang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents

(2020) Minghui Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proline Hinged Amphipathic α-Helical Peptide Sensitizes Gram-Negative Bacteria to Various Gram-Positive Antibiotics

(2020) Soonsil Hyun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dimerization of antimicrobial peptides: a promising strategy to enhance antimicrobial peptide activity

(2019) E. N Lorenzón et al.   PROTEIN AND PEPTIDE LETTERS

From Antimicrobial to Anticancer Peptides: The Transformation of Peptides

(2019) Yuan Qin et al.   Recent Patents on Anti-Cancer Drug Discovery

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies

(2019) Andrew J. Tague et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

(2019) Andrew J. Tague et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism

(2019) Yinfeng Lyu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties

(2019) Karen G. N. Oshiro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipidated α/Sulfono-α-AA heterogeneous peptides as antimicrobial agents for MRSA

(2019) Sylvia Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Progress in Polymer Research to Tackle Infections and Antimicrobial Resistance

(2018) Mohini Mohan Konai et al.   BIOMACROMOLECULES

Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile

(2018) Chunhui Li et al.   ChemMedChem

Lipidated α/α-AA heterogeneous peptides as antimicrobial agents

(2018) Sylvia Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents

(2018) Youhong Niu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity

(2018) Mônica Samuel Avila et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol

(2018) Jingqiu Wang et al.   PLoS One

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

(2018) Willy Chin et al.   Nature Communications

Synthesis, in-Vitro and in Silico Studies of Azo-Based Calix[4]arenes as Antibacterial Agent and Neuraminidase Inhibitor: A New Look Into an Old Scaffold

(2018) Yousaf Ali et al.   Frontiers in Chemistry

Decoupling the Functional Roles of Cationic and Hydrophobic Groups in the Antimicrobial and Hemolytic Activities of Methacrylate Random Copolymers

(2018) Hamid Mortazavian et al.   BIOMACROMOLECULES

Macromolecular-clustered facial amphiphilic antimicrobials

(2018) Md Anisur Rahman et al.   Nature Communications

Preclinical testing of a broad-spectrum antimicrobial endotracheal tube coated with an innate immune synthetic mimic

(2017) Marjan M Hashemi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans

(2017) Krishna K. Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism

(2017) Xiujing Dou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane-Active Hydantoin Derivatives as Antibiotic Agents

(2017) Ma Su et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances and perspectives in the design and development of polymyxins

(2017) Francesc Rabanal et al.   NATURAL PRODUCT REPORTS

Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis

(2017) Ewelina Piktel et al.   Scientific Reports

Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis

(2017) Maarten Coorens et al.   Scientific Reports

Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13

(2017) Katarzyna Niemirowicz et al.   Scientific Reports

A Vancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria

(2016) Venkateswarlu Yarlagadda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polycarbonates with Potent and Selective Antimicrobial Activity toward Gram-Positive Bacteria

(2016) Alekhya Nimmagadda et al.   BIOMACROMOLECULES

Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes

(2016) Douglas R. Rice et al.   CHEMICAL COMMUNICATIONS

γ-AApeptides as a New Class of Peptidomimetics

(2016) Peng Teng et al.   CHEMISTRY-A EUROPEAN JOURNAL

Spatiotemporal control of the creation and immolation of peptide assemblies

(2016) Yang Hu et al.   COORDINATION CHEMISTRY REVIEWS

New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities

(2016) Yousry A. Ammar et al.   CURRENT ORGANIC SYNTHESIS

Small Antimicrobial Agents Based on Acylated Reduced Amide Scaffold

(2016) Peng Teng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles

(2016) Zhi Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

(2016) Ranganath Gopalakrishnan et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-Infective

(2016) Regis P. Kowalski et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Synthesis, molecular properties, toxicity and biological evaluation of some new substituted imidazolidine derivatives in search of potent anti-inflammatory agents

(2016) Asif Husain et al.   SAUDI PHARMACEUTICAL JOURNAL

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

β-Peptoid Foldamers at Last

(2015) Jonas S. Laursen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection

(2015) Robert Bucki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kaempferol inhibits thrombosis and platelet activation

(2015) Jun-Hui Choi et al.   BIOCHIMIE

Peptoids and Polypeptoids at the Frontier of Supra- and Macromolecular Engineering

(2015) Niklas Gangloff et al.   CHEMICAL REVIEWS

Biological potential of carbazole derivatives

(2015) Agata Głuszyńska   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Imidazolidine-4-one derivatives in the search for novel chemosensitizers of Staphylococcus aureus MRSA: Synthesis, biological evaluation and molecular modeling studies

(2015) Anna Matys et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms

(2015) Jiaul Hoque et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens

(2015) Renee Fleeman et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16

(2014) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

LTX-109 Is a Novel Agent for Nasal Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus

(2014) Anna C. Nilsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cationic Methacrylate Polymers as Topical Antimicrobial Agents against Staphylococcus aureus Nasal Colonization

(2014) Laura M. Thoma et al.   BIOMACROMOLECULES

Short Antimicrobial Lipo-α/γ-AA Hybrid Peptides

(2014) Yaqiong Li et al.   CHEMBIOCHEM

Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

(2014) Marie Stiborová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections

(2014) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of New Benzimidazole–Carbazole Conjugates for the Stabilization of Human Telomeric DNA, Telomerase Inhibition, and Their Selective Action on Cancer Cells

(2014) Basudeb Maji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecular Antibacterial Peptoid Mimics: The Simpler the Better!

(2014) Chandradhish Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

(2014) Rasmus D. Jahnsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipidated α-Peptide/β-Peptoid Hybrids with Potent Anti-inflammatory Activity

(2014) Sarah L. Skovbakke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Constituents of the Roots of Clausena lansium and Their Potential Anti-inflammatory Activity

(2014) De-Yang Shen et al.   JOURNAL OF NATURAL PRODUCTS

Antibacterial Activities of Amphiphilic Cyclic Cell-Penetrating Peptides against Multidrug-Resistant Pathogens

(2014) Donghoon Oh et al.   MOLECULAR PHARMACEUTICS

Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-ResistantAcinetobacter baumanniiStrains Isolated from Bacteremia Patients

(2014) Cagla Bozkurt-Guzel et al.   Biomed Research International

Controlling Helix Formation in the γ-Peptide Superfamily: Heterogeneous Foldamers with Urea/Amide and Urea/Carbamate Backbones

(2013) Nagendar Pendem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic quaternized aminocalix[4]arenes: cytotoxicity, haemolytic and antibacterial activities

(2013) Elena V. Ukhatskaya et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Design and Synthesis of Amphiphilic Xanthone-Based, Membrane-Targeting Antimicrobials with Improved Membrane Selectivity

(2013) Hanxun Zou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Self-Assembly to Function: Design, Synthesis, and Broad Spectrum Antimicrobial Properties of Short Hybrid E-Vinylogous Lipopeptides

(2013) S. Shiva Shankar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Antimicrobial properties of enzymatically triggered self-assembling aromatic peptide amphiphiles

(2013) Meghan Hughes et al.   Biomaterials Science

Health Care–Associated Infections

(2013) Eyal Zimlichman et al.   JAMA Internal Medicine

Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: An in vitro efficacy study

(2012) S.-H. Chen et al.   Acta Biomaterialia

In VitroActivities of LTX-109, a Synthetic Antimicrobial Peptide, against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus

(2012) Louis D. Saravolatz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting

(2012) Jun-Jie Koh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Xanthones from Fungi, Lichens, and Bacteria: The Natural Products and Their Synthesis

(2012) Kye-Simeon Masters et al.   CHEMICAL REVIEWS

Anion recognition and sensing with Zn(ii)–dipicolylamine complexes

(2012) Huy Tien Ngo et al.   CHEMICAL SOCIETY REVIEWS

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

(2012) Allen Y. Chen et al.   FOOD CHEMISTRY

Lipo-γ-AApeptides as a New Class of Potent and Broad-Spectrum Antimicrobial Agents

(2012) Youhong Niu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Mimics of Antimicrobial Peptides with Immunomodulatory Responses

(2012) Hitesh D. Thaker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging trends in macromolecular antimicrobials to fight multi-drug-resistant infections

(2012) Amanda C. Engler et al.   Nano Today

Antibacterial Mechanism of Action of Arylamide Foldamers

(2011) Bruk Mensa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Self-assembling peptide scaffolds for regenerative medicine

(2011) John B. Matson et al.   CHEMICAL COMMUNICATIONS

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

Colistin: new lessons on an old antibiotic

(2011) D. Yahav et al.   CLINICAL MICROBIOLOGY AND INFECTION

Azapeptides and their therapeutic potential

(2011) Caroline Proulx et al.   Future Medicinal Chemistry

Daptomycin: evaluation of a high-dose treatment strategy

(2011) Gary Wu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Regulators of G Protein Signaling (RGS) Proteins as Drug Targets: Modulating G-Protein-Coupled Receptor (GPCR) Signal Transduction

(2011) David L. Roman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Elucidating the Molecular Basis of Action of a Classic Drug: Guanidine Compounds As Inhibitors of Voltage-Gated Potassium Channels

(2011) J. Kalia et al.   MOLECULAR PHARMACOLOGY

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines

(2011) Ana Camila Micheletti et al.   QUIMICA NOVA

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold

(2010) B. Findlay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Activities of Short Designer Peptides: a Link between Propensity for Nanostructuring and Capacity for Membrane Destabilization

(2010) Cuixia Chen et al.   BIOMACROMOLECULES

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity

(2010) Ivanna Subtel’na et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimicrobial Activity of Short, Synthetic Cationic Lipopeptides

(2010) Garry Laverty et al.   Chemical Biology & Drug Design

Recent Insights into the Biosynthesis and Biological Activities of Natural Xanthones

(2010) H. El-Seedi et al.   CURRENT MEDICINAL CHEMISTRY

Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates

(2010) Smritilekha Bera et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections

(2010) K. Leszczyńska et al.   JOURNAL OF APPLIED MICROBIOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Oligooxopiperazines as Nonpeptidic α-Helix Mimetics

(2010) Petra Tošovská et al.   ORGANIC LETTERS

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

(2009) Gregory N. Tew et al.   ACCOUNTS OF CHEMICAL RESEARCH

Binaphthyl-Based Dicationic Peptoids with Therapeutic Potential

(2009) John B. Bremner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats

(2009) Cheng Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Bombinins, antimicrobial peptides from Bombina species

(2009) Maurizio Simmaco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Determinants of Antimicrobial Activity and Biocompatibility in Membrane-Disrupting Methacrylamide Random Copolymers

(2009) Edmund F. Palermo et al.   BIOMACROMOLECULES

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities

(2009) Adel Garas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Advances in the Synthesis and Applications of Reduced Amide Pseudopeptides

(2009) Matej Zivec et al.   CURRENT MEDICINAL CHEMISTRY

Antimicrobial Activity of Small β-Peptidomimetics Based on the Pharmacophore Model of Short Cationic Antimicrobial Peptides

(2009) Terkel Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides

(2008) Xin-Zhong Lai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Antimicrobial Lipopolypeptides Composed of Palmitoyl Di- and Tricationic Peptides:In Vitroandin VivoActivities, Self-Assembly to Nanostructures, and a Plausible Mode of Action†

(2008) Arik Makovitzki et al.   BIOCHEMISTRY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms

(2008) K. Flemming et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synthetic Antimicrobial Peptidomimetics with Therapeutic Potential

(2008) Bengt Erik Haug et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach

(2008) Karen Lienkamp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY