A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
出版年份 2022 全文链接
标题
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
作者
关键词
-
出版物
NATURE GENETICS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-06-03
DOI
10.1038/s41588-022-01078-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease
- (2021) Oveis Jamialahmadi et al. GASTROENTEROLOGY
- Quantification of abdominal fat from computed tomography using deep learning and its association with electronic health records in an academic biobank
- (2021) Matthew T MacLean et al. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
- Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology
- (2021) Vincent L. Chen et al. Nature Communications
- A single cell gene expression atlas of 28 human livers
- (2021) Joseph Brancale et al. JOURNAL OF HEPATOLOGY
- Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
- (2021) Raha Pazoki et al. Nature Communications
- Selonsertib for Patients with Bridging Fibrosis or Compensated Cirrhosis Due to NASH: Results from Randomized Ph III STELLAR Trials
- (2020) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort
- (2020) Quentin M. Anstee et al. JOURNAL OF HEPATOLOGY
- Improving the coverage of credible sets in Bayesian genetic fine-mapping
- (2020) Anna Hutchinson et al. PLoS Computational Biology
- A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
- (2020) Connor A. Emdin et al. PLoS Genetics
- The Impact of Education and Age on Metabolic Disorders
- (2020) Christopher R. Stephens et al. Frontiers in Public Health
- Multiple Parallel Hits Hypothesis in NAFLD – Revisited After a Decade
- (2020) Herbert Tilg et al. HEPATOLOGY
- Exploring and visualizing large-scale genetic associations by using PheWeb
- (2020) Sarah A. Gagliano Taliun et al. NATURE GENETICS
- Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
- (2020) Marina Serper et al. PLoS One
- Home use of a compact, 12‑lead ECG recording system for newborns
- (2019) Henry J. Lin et al. JOURNAL OF ELECTROCARDIOLOGY
- Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
- (2019) Paul S de Vries et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver
- (2019) Minal Çalışkan et al. AMERICAN JOURNAL OF HUMAN GENETICS
- GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
- (2019) Bahram Namjou et al. BMC Medicine
- Benchmark and integration of resources for the estimation of human transcription factor activities
- (2019) Luz Garcia-Alonso et al. GENOME RESEARCH
- A catalog of genetic loci associated with kidney function from analyses of a million individuals
- (2019) Matthias Wuttke et al. NATURE GENETICS
- Genome‐Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium
- (2019) Kendra A. Young et al. Obesity
- Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
- (2019) Henry R. Kranzler et al. Nature Communications
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
- (2019) Adrienne Tin et al. NATURE GENETICS
- Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- (2019) Alexander Teumer et al. Nature Communications
- RORα suppresses interleukin-6-mediated hepatic acute phase response
- (2019) Ju-Yeon Kim et al. Scientific Reports
- Bringing data from curated pathway resources to Cytoscape with OmniPath
- (2019) Francesco Ceccarelli et al. BIOINFORMATICS
- AUDIT-C and ICD Codes as Phenotypes for Harmful Alcohol Use: Association with ADH1B Polymorphisms in Two U.S. Populations
- (2018) Amy C. Justice et al. ADDICTION
- Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride
- (2018) Stefan Stender et al. HEPATOLOGY
- NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
- (2018) Eeva Sliz et al. HUMAN MOLECULAR GENETICS
- Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
- (2018) Hilary K. Finucane et al. NATURE GENETICS
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies
- (2018) Andreea-Manuela Mirea et al. TRENDS IN MOLECULAR MEDICINE
- The MR-Base platform supports systematic causal inference across the human phenome
- (2018) Gibran Hemani et al. eLife
- Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
- (2018) Sara L Pulit et al. HUMAN MOLECULAR GENETICS
- Burden of Liver Diseases in the World
- (2018) Sumeet K. Asrani et al. JOURNAL OF HEPATOLOGY
- Genomic atlas of the human plasma proteome
- (2018) Benjamin B. Sun et al. NATURE
- Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
- (2018) Wei Zhou et al. NATURE GENETICS
- The Human Transcription Factors
- (2018) Samuel A. Lambert et al. CELL
- Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
- (2018) Ayush Giri et al. NATURE GENETICS
- Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
- (2018) Derek Klarin et al. NATURE GENETICS
- STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
- (2018) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
- (2017) Naga Chalasani et al. HEPATOLOGY
- Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
- (2017) Chris Estes et al. HEPATOLOGY
- Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis
- (2017) Minal B. Mehta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys
- (2017) Julia Wattacheril et al. JOURNAL OF PEDIATRICS
- Pharmacogenomics: Precision Medicine and Drug Response
- (2017) Richard M. Weinshilboum et al. MAYO CLINIC PROCEEDINGS
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis
- (2017) Giovanni Musso et al. JAMA Internal Medicine
- TRIB1 is a positive regulator of hepatocyte nuclear factor 4-alpha
- (2017) Sébastien Soubeyrand et al. Scientific Reports
- Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus
- (2016) Kenneth Cusi et al. ANNALS OF INTERNAL MEDICINE
- The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
- (2016) William J. Astle et al. CELL
- Nonalcoholic Fatty Liver Disease
- (2016) Rotonya M. Carr et al. GASTROENTEROLOGY CLINICS OF NORTH AMERICA
- Million Veteran Program: A mega-biobank to study genetic influences on health and disease
- (2016) John Michael Gaziano et al. JOURNAL OF CLINICAL EPIDEMIOLOGY
- Reference-based phasing using the Haplotype Reference Consortium panel
- (2016) Po-Ru Loh et al. NATURE GENETICS
- OmniPath: guidelines and gateway for literature-curated signaling pathway resources
- (2016) Dénes Türei et al. NATURE METHODS
- Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
- (2016) Frederick E. Dewey et al. SCIENCE
- Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
- (2016) Johannes Kettunen et al. Nature Communications
- GREGOR: evaluating global enrichment of trait-associated variants in epigenomic features using a systematic, data-driven approach
- (2015) Ellen M. Schmidt et al. BIOINFORMATICS
- Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
- (2015) Paul Angulo et al. GASTROENTEROLOGY
- Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
- (2015) H. Guo et al. HUMAN MOLECULAR GENETICS
- Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
- (2015) Melissa Baxter et al. JOURNAL OF HEPATOLOGY
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Genome-wide identification of zero nucleotide recursive splicing in Drosophila
- (2015) Michael O. Duff et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- (2015) Hilary K Finucane et al. NATURE GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- Gene expression analysis identifies global gene dosage sensitivity in cancer
- (2015) Rudolf S N Fehrmann et al. NATURE GENETICS
- Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?
- (2015) Martijn C.G.J. Brouwers et al. TRENDS IN MOLECULAR MEDICINE
- Biological interpretation of genome-wide association studies using predicted gene functions
- (2015) Tune H. Pers et al. Nature Communications
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- Nonalcoholic fatty liver disease (NAFLD) in the Veterans Administration population: development and validation of an algorithm for NAFLD using automated data
- (2014) N. Husain et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- An atlas of active enhancers across human cell types and tissues
- (2014) Robin Andersson et al. NATURE
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
- (2014) Claudia Giambartolomei et al. PLoS Genetics
- CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells
- (2014) Soona Shin et al. Molecular Metabolism
- Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency
- (2013) Wilhelm Stoffel et al. EMBO REPORTS
- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
- (2013) Linn Fagerberg et al. MOLECULAR & CELLULAR PROTEOMICS
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Large-scale association analysis identifies new risk loci for coronary artery disease
- (2012) Panos Deloukas et al. NATURE GENETICS
- Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
- (2012) Alexander Laatsch et al. PLoS One
- A Feedback Loop Between the Liver-Enriched Transcription Factor Network and Mir-122 Controls Hepatocyte Differentiation
- (2011) Ilaria Laudadio et al. GASTROENTEROLOGY
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- (2011) John C Chambers et al. NATURE GENETICS
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
- (2010) J. C. Denny et al. BIOINFORMATICS
- METAL: fast and efficient meta-analysis of genomewide association scans
- (2010) C. J. Willer et al. BIOINFORMATICS
- Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease
- (2010) Naga Chalasani et al. GASTROENTEROLOGY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
- (2009) Vlad Ratziu et al. HEPATOLOGY
- Development of a Large-Scale De-Identified DNA Biobank to Enable Personalized Medicine
- (2008) DM Roden et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Clinical Correlates of Histopathology in Pediatric Nonalcoholic Steatohepatitis
- (2008) Heather M. Patton et al. GASTROENTEROLOGY
- Bayes factors for genome-wide association studies: comparison withP-values
- (2008) Jon Wakefield GENETIC EPIDEMIOLOGY
- A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
- (2008) J. D. Cahoy et al. JOURNAL OF NEUROSCIENCE
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started