Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo

(2022) Marina Arjona et al.   Stem Cell Reports

Adult tissue-resident stem cells—fact or fiction?

(2021) Deepa Bhartiya   Stem Cell Research & Therapy

Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

(2021) Matias Fuentealba et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA damage—how and why we age?

(2021) Matt Yousefzadeh et al.   eLife

The central role of DNA damage in the ageing process

(2021) Björn Schumacher et al.   NATURE

Importance of circadian timing for aging and longevity

(2021) Victoria A. Acosta-Rodríguez et al.   Nature Communications

Offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization

(2021) Huacheng Luo et al.   Journal of Advanced Research

Revelations About Aging and Disease from Unconventional Vertebrate Model Organisms

(2021) Yang Zhao et al.   Annual Review of Genetics

Genetic insights into biological mechanisms governing human ovarian ageing

(2021) Katherine S. Ruth et al.   NATURE

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

(2021) Yanpu Chen et al.   SCIENCE

Sirtuin 6: linking longevity with genome and epigenome stability

(2021) Anatoly Korotkov et al.   TRENDS IN CELL BIOLOGY

DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

(2021) Stefano Bonassi et al.   Scientific Reports

Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging

(2021) Csaba Kerepesi et al.   Science Advances

TBX20 Contributes to Balancing the Differentiation of Perivascular Adipose-Derived Stem Cells to Vascular Lineages and Neointimal Hyperplasia

(2021) Yongli Ji et al.   Frontiers in Cell and Developmental Biology

Circadian autophagy drives iTRF-mediated longevity

(2021) Matt Ulgherait et al.   NATURE

Origins and evolution of extreme life span in Pacific Ocean rockfishes

(2021) Sree Rohit Raj Kolora et al.   SCIENCE

Antiaging diets: Separating fact from fiction

(2021) Mitchell B. Lee et al.   SCIENCE

Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation

(2021) Quanwei Zhang et al.   Cell Reports

Transcriptional responses of skeletal stem/progenitor cells to hindlimb unloading and recovery correlate with localized but not systemic multi-systems impacts

(2021) Cori N. Booker et al.   NPJ Microgravity

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

(2020) Jessica M. Stringer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

The World Goes Bats: Living Longer and Tolerating Viruses

(2020) Vera Gorbunova et al.   Cell Metabolism

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Germline mutation rates in young adults predict longevity and reproductive lifespan

(2020) Richard M. Cawthon et al.   Scientific Reports

Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity

(2020) Xuming Zhou et al.   Cell Reports

Transcriptomic signatures across human tissues identify functional rare genetic variation

(2020) Nicole M. Ferraro et al.   SCIENCE

Canagliflozin extends lifespan in genetically heterogeneous male but not female mice

(2020) Richard A. Miller et al.   JCI Insight

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration

(2020) Seiji Ishii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of Centriole and Cilium Biogenesis

(2019) David K. Breslow et al.   Annual Review of Biochemistry

Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap

(2019) Jüri Reimand et al.   Nature Protocols

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma

(2019) María Álvarez-Satta et al.   AGEING RESEARCH REVIEWS

Relaxed Selection Limits Lifespan by Increasing Mutation Load

(2019) Rongfeng Cui et al.   CELL

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

(2019) Alexander Tyshkovskiy et al.   Cell Metabolism

ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

(2019) Javier Koh et al.   Nature Communications

Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats

(2019) Zixia Huang et al.   Nature Ecology & Evolution

Centrobin plays a role in the cellular response to DNA damage

(2019) Na Mi Ryu et al.   CELL CYCLE

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

The Complexity of PRC2 Subcomplexes

(2019) Guido van Mierlo et al.   TRENDS IN CELL BIOLOGY

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

(2019) Qi Sun et al.   Nature Communications

Inferring the mammal tree: Species-level sets of phylogenies for questions in ecology, evolution, and conservation

(2019) Nathan S. Upham et al.   PLOS BIOLOGY

ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R

(2018) Emmanuel Paradis et al.   BIOINFORMATICS

Innate Immunity of the Lung: From Basic Mechanisms to Translational Medicine

(2018) Dominik Hartl et al.   Journal of Innate Immunity

Circadian regulation of glucose, lipid, and energy metabolism in humans

(2018) Eleonora Poggiogalle et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AAV vector-mediated in vivo reprogramming into pluripotency

(2018) Elena Senís et al.   Nature Communications

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity

(2018) Nicole M. Foley et al.   Science Advances

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

(2018) Claudio Franceschi et al.   Nature Reviews Endocrinology

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Elucidating the Role of Protandim and 6-Gingerol in Protection Against Osteoarthritis

(2017) Jamilah Abusarah et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic epigenomic landscapes during early lineage specification in mouse embryos

(2017) Yu Zhang et al.   NATURE GENETICS

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Human Ageing Genomic Resources: new and updated databases

(2017) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

(2017) Lorenzo Rinaldi et al.   eLife

mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice

(2016) Graham Dominick et al.   AGING CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

(2016) Duozhuang Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potassium channels in the heart: structure, function and regulation

(2016) Eleonora Grandi et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

The landscape of accessible chromatin in mammalian preimplantation embryos

(2016) Jingyi Wu et al.   NATURE

Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming

(2016) Jun Chen et al.   Cell Reports

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

(2016) Michael Sulak et al.   eLife

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

(2016) Mario Baumgart et al.   Cell Systems

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing

(2016) Matae Ahn et al.   Scientific Reports

Gene expression defines natural changes in mammalian lifespan

(2015) Alexey A. Fushan et al.   AGING CELL

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

(2015) Konstantinos Dean Boudoulas et al.   CARDIOLOGY

Centrosomes in the DNA damage response—the hub outside the centre

(2015) Lisa I. Mullee et al.   CHROMOSOME RESEARCH

What is the DNA repair defect underlying Fanconi anemia?

(2015) Julien P Duxin et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

(2015) Graham Dominick et al.   ENDOCRINOLOGY

Insights into the Evolution of Longevity from the Bowhead Whale Genome

(2015) Michael Keane et al.   Cell Reports

Animal Models of Aging Research: Implications for Human Aging and Age-Related Diseases

(2015) Sarah J. Mitchell et al.   Annual Review of Animal Biosciences

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

UpSet: Visualization of Intersecting Sets

(2014) Alexander Lex et al.   IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS

Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression

(2014) Yunus Annayev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal Loss

(2014) Y. Lee et al.   JOURNAL OF NEUROSCIENCE

Comparative genetics of longevity and cancer: insights from long-lived rodents

(2014) Vera Gorbunova et al.   NATURE REVIEWS GENETICS

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer

(2013) German A. Pihan   Frontiers in Oncology

CD-HIT: accelerated for clustering the next-generation sequencing data

(2012) Limin Fu et al.   BIOINFORMATICS

Mitochondria and Organismal Longevity

(2012) Ara B. Hwang et al.   CURRENT GENOMICS

Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress

(2012) Danielle J. Reuland et al.   FREE RADICAL BIOLOGY AND MEDICINE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

(2012) Lisette Stolk et al.   NATURE GENETICS

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

(2012) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Glucose handling by the kidney

(2011) Amanda Mather et al.   KIDNEY INTERNATIONAL

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy

(2011) K. D. Pruitt et al.   NUCLEIC ACIDS RESEARCH

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

(2009) S. P. Singh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Stress-Response Hormesis and Aging: “That which Does Not Kill Us Makes Us Stronger”

(2008) David Gems et al.   Cell Metabolism