期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 158, 期 3, 页码 377-379出版社
SPRINGER
DOI: 10.1007/s10517-015-2766-3
关键词
cell redox status; oxidative stress; heat shock protein 27; tumor progression; apoptosis
资金
- Ministry of Education and Science of the Russian Federation [8302]
- Russian Federation for State Support of the Leading Scientific Schools [16.120.11.614-NSh]
- Program for Improving the Competitive Capacity of Tomsk State University
Reaction of the glutathione system of Jurkat tumor cells and blood lymphocytes was evaluated under conditions of culturing with 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl) isoxazole (KRIBB3), a selective inhibitor of heat shock protein Hsp27. The results indicated the regulatory role of Hsp27 in the maintenance of the functional activities of glutathione reductase, glutathione peroxidase, and realization of apoptotic death of Jurkat cells and blood lymphocytes. Inhibition of Hsp27 in Jurkat tumor cells led to imbalance of the glutathione system and increase of the share of annexin-positive cells.
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