The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

(2021) Joan Serrano et al.   Microbiome

Critically evaluating sweet taste receptor expression and signaling through a molecular pharmacology lens

(2021) Nicola J. Smith et al.   FEBS Journal

Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells

(2020) Elisa Bovo et al.   BIOPHYSICAL JOURNAL

Impact of Gut Microbiota on Host Glycemic Control

(2019) Céline Gérard et al.   Frontiers in Endocrinology

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

(2019) Jihye Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers

(2019) Deo R. Singh et al.   JOURNAL OF MOLECULAR BIOLOGY

Genes from the TAS1R and TAS2R Families of Taste Receptors: Looking for Signatures of Their Adaptive Role in Human Evolution

(2018) Cristina Valente et al.   Genome Biology and Evolution

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

(2018) Kathleen Smith et al.   Molecular Metabolism

Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children

(2017) Silvia V. Melo et al.   GENETICS AND MOLECULAR BIOLOGY

Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity

(2016) Kathleen R. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico

(2016) Omar Ramos-Lopez et al.   Nutrients

Variation in the TAS1R2 Gene, Sweet Taste Perception and Intake of Sugars

(2015) Andre G. Dias et al.   Journal of Nutrigenetics and Nutrigenomics

Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice

(2014) George A. Kyriazis et al.   ENDOCRINOLOGY

Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids

(2014) Keisuke Sanematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Human and Mouse Membrane Trafficking Systems for Sweet Taste Receptors T1r2 and T1r3

(2014) Madoka Shimizu et al.   PLoS One

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

(2012) G. A. Kyriazis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations

(2010) Karen M Eny et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males

(2010) Christian Anderwald et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE