Interactions between islets and regulatory immune cells in health and type 1 diabetes

Induced regulatory T cells suppress Tc1 cells through TGF-β signaling to ameliorate STZ-induced type 1 diabetes mellitus

(2021) Li Zhou et al.   Cellular & Molecular Immunology

One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

(2021) Teresa Rodriguez-Calvo et al.   DIABETES

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes

(2021) Christine Bender et al.   Frontiers in Endocrinology

T cells accumulate in non-diabetic islets during ageing

(2021) Heather C. Denroche et al.   Immunity & Ageing

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

(2021) Michael Delacher et al.   IMMUNITY

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration

(2021) Diane C. Saunders et al.   npj Regenerative Medicine

Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes

(2021) Maria Bettini et al.   DIABETES

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

(2020) Courtney Ackeifi et al.   Science Translational Medicine

Increased islet antigen–specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes–protective haplotype

(2020) Xiaomin Wen et al.   Science Immunology

C-Peptide Levels in Subjects Followed Longitudinally Before and After Type 1 Diabetes Diagnosis in TrialNet

(2020) Magdalena M. Bogun et al.   DIABETES CARE

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

(2020) Pavel N. Zakharov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective

(2020) Gonçalo S. Clemente et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome

(2020) Dan Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

(2020) Mirza Muhammad Fahd Qadir et al.   Nature Communications

Current progress in stem cell therapy for type 1 diabetes mellitus

(2020) Shuai Chen et al.   Stem Cell Research & Therapy

Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis

(2020) Julia K. Panzer et al.   JCI Insight

Organisation of the human pancreas in health and in diabetes

(2020) Mark A. Atkinson et al.   DIABETOLOGIA

IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival

(2020) Qingsong Huang et al.   EMBO Molecular Medicine

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

(2020) Christine Bender et al.   Science Advances

Modulation of macrophage polarity for treatment of acute pancreatitis: Are we there yet?

(2020) Preeti Sahay et al.   EBioMedicine

Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes

(2020) Teresa Quattrin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of autoimmunity by mixed chimerism enables reactivation of β cells and transdifferentiation of α cells in diabetic NOD mice

(2020) Shanshan Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Nucleus and In Situ RNA–Sequencing Reveal Cell Topographies in the Human Pancreas

(2020) Luca Tosti et al.   GASTROENTEROLOGY

CRTAM+ NK cells endowed with suppressor properties arise in leukemic bone marrow

(2019) Dalia Ramírez-Ramírez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate Control of Tissue-Reparative Human Regulatory T Cells

(2019) Avery J. Lam et al.   JOURNAL OF IMMUNOLOGY

Modulation of macrophage phenotype via phagocytosis of drug-loaded microparticles

(2019) Kathryn L. Wofford et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

(2019) Hideaki Morita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune and non-immune mediated roles of regulatory T-cells during wound healing

(2019) Dietmar M. Zaiss et al.   IMMUNOLOGY

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

(2019) Richard A. Oram et al.   DIABETOLOGIA

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Islet inflammation in type 2 diabetes

(2019) Marianne Böni-Schnetzler et al.   Seminars in Immunopathology

Islet‐Immune Interactions in Type 1 Diabetes: The Nexus of Beta Cell Destruction

(2019) Leeana Peters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

VEGF-A and blood vessels: a beta cell perspective

(2019) Willem Staels et al.   DIABETOLOGIA

Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells

(2019) Laura Cook et al.   GASTROENTEROLOGY

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

(2019) Shi Yong Neo et al.   JOURNAL OF CLINICAL INVESTIGATION

Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro

(2019) Mostafa Bakhti et al.   Molecular Metabolism

New function of zebrafish regulatory T cells in organ regeneration

(2019) Kazu Kikuchi   CURRENT OPINION IN IMMUNOLOGY

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

(2018) Michela Miani et al.   Cell Metabolism

Advances in drug discovery for human beta cell regeneration

(2018) Esra Karakose et al.   DIABETOLOGIA

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells

(2018) Valeria Marca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury

(2018) Qi Cao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Revealing the specificity of regulatory T cells in murine autoimmune diabetes

(2018) Allyson Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion

(2018) Marianne Böni-Schnetzler et al.   Cell Reports

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes

(2018) Oscar M. Leung et al.   Cell Reports

Stem-cell based organ-on-a-chip models for diabetes research

(2018) Julia Rogal et al.   ADVANCED DRUG DELIVERY REVIEWS

Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity

(2018) Wei Ying et al.   Cell Metabolism

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

(2018) Peng Wang et al.   Cell Metabolism

Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency

(2018) Alma-Martina Cepika et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

(2017) Elise Dalmas et al.   IMMUNITY

Regulatory T cells in skin

(2017) Niwa Ali et al.   IMMUNOLOGY

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

(2017) Danny W. Bruce et al.   JOURNAL OF CLINICAL INVESTIGATION

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

(2017) Stephen T. Ferris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A distinct innate lymphoid cell population regulates tumor-associated T cells

(2017) Sarah Q Crome et al.   NATURE MEDICINE

β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?

(2017) Teresa Rodriguez-Calvo et al.   Nature Reviews Endocrinology

Innate lymphoid cells in autoimmunity: emerging regulators in rheumatic diseases

(2017) Medya M. Shikhagaie et al.   Nature Reviews Rheumatology

Alternative activation generates IL-10 producing type 2 innate lymphoid cells

(2017) Corey R. Seehus et al.   Nature Communications

Co-encapsulation and co-transplantation of mesenchymal stem cells reduces pericapsular fibrosis and improves encapsulated islet survival and function when allografted

(2017) Vijayaganapathy Vaithilingam et al.   Scientific Reports

Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function

(2017) Robert Michael Petri et al.   Stem Cell Reports

Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes

(2017) Christina L. Graves et al.   Frontiers in Immunology

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Restoring Regulatory T Cells in Type 1 Diabetes

(2016) Allyson Spence et al.   Current Diabetes Reports

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

(2016) Chris Fraker et al.   Current Diabetes Reports

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

P2X1-regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration

(2016) Ramesh Kudira et al.   HEPATOLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing

(2016) Gregory D. Rak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

(2016) Bruce A. Corliss et al.   MICROCIRCULATION

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

(2016) Anoop Babu Vasandan et al.   Scientific Reports

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Defining Pathways for Development of Disease-Modifying Therapies in Children With Type 1 Diabetes: A Consensus Report

(2015) Diane K. Wherrett et al.   DIABETES CARE

Emerging Functions of Amphiregulin in Orchestrating Immunity, Inflammation, and Tissue Repair

(2015) Dietmar M.W. Zaiss et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells

(2015) Anthony N. Vomund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation

(2015) Xiangwei Xiao et al.   Stem Cells Translational Medicine

Macrophages at the Fork in the Road to Health or Disease

(2015) Charles D. Mills et al.   Frontiers in Immunology

IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice

(2014) Clara Y. Westwell-Roper et al.   DIABETOLOGIA

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice

(2014) Xiaocang Cao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes

(2014) Bo Zhang et al.   NATURE MEDICINE

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

(2012) Alan M. Hanash et al.   IMMUNITY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology