期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 32, 页码 13379-13384出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004439
关键词
alkene difunctionalization; bifunctional reagent; photocatalysis; site-selective; trifluoromethylative pyridylation
资金
- Institute for Basic Science [IBS-R010-A2]
A general strategy for visible-light-enabled site-selective trifluoromethylative pyridylation of unactivated alkenes has been developed using pyridines and triflic anhydride (Tf2O). Intriguingly, the N-triflylpyridinium salts, generated in situ from pyridines and Tf2O, serve as effective modular bifunctional reagents to install both CF3 and pyridyl groups to various olefins while controlling C4-selectivity in radical addition to the pyridine core. This synthetic route exhibited broad substrate scope under metal-free and mild photocatalytic conditions, granting efficient access to valuable C4-alkylated pyridines and quinolines without requiring prefunctionalization of the reaction site.
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