期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 54, 期 10, 页码 N177-N188出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/54/10/N01
关键词
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资金
- National Institutes of Health (NIH) [NIH 1RO1 EB002657, NOI-CO-27173, 1 R01 CA119409]
- Michigan Economic Development Corporation-Life Sciences Corridor Fund [GR-472]
We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was similar to 1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.
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