Fenugreek-based exosome like nanoparticles: A point of care vehicle for alleviating the pain intensity produced at primary dysmenorrheal condition in female of child bearing age

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作者

Amoolya Sree¹ , Tamilvanan Shunmugaperumal¹

1. NIPER, Guwahati

会议/活动

Exotech, October 2022 (虚拟会议)

海报摘要

Fenugreek-based exosome like-nanoparticles (FEN-ELN) was prepared as a point of care vehicle for alleviating the pain intensity produced at primary dysmenorrheal condition. FEN-ELN, generated using polymer precipitation technique was screened to study the critical attributes which are likely to affect the quality and yield. Further, several characterization studies (size, zeta potential, trigonelline content, etc.) were conducted to evaluate the generated FEN-ELN. The successfully isolated FEN-ELN had an average diameter of 122.2 nm, negative surface charge of −21.9 mV and a concentration of 8.3 × 1010 particles/mL. Both the total protein and RNA concentration were deemed satisfactory.

关键词

Exosome like-nanoparticles, Fenugreek, Primary dysmenorrhea, RP-HPLC

研究领域

Pharmacy and Pharmacology

参考文献

1. 1. Ly, N. P., Han, H. S., Kim, M., Park, J. H., & Choi, K. Y. (2023). Plant-derived nanovesicles: Current understanding and applications for cancer therapy. Bioactive Materials, 22, 365-383.
2. 2. Kim, J., Lee, Y. H., Wang, J., Kim, Y. K., & Kwon, I. K. (2022). Isolation and characterization of ginseng-derived exosome-like nanoparticles with sucrose cushioning followed by ultracentrifugation. SN Applied Sciences, 4(2), 63.
3. 3. Kalarikkal, S. P., Prasad, D., Kasiappan, R., Chaudhari, S. R., & Sundaram, G. M. (2020). A cost-effective polyethylene glycol-based method for the isolation of functional edible nanoparticles from ginger rhizomes. Scientific reports, 10(1), 1-12.

基金

暂无数据

补充材料

1. FEN-ELN formation checked by Nanoparticle Tracking Analyzer   Download

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Sree et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.