mGluR4-positive allosteric modulation as potential treatment for Parkinson’s disease

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

(2008) Colleen M. Niswender et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead

(2008) Richard Williams et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: Behavioral and histological analyses

(2008) Takashi Agari et al.   BRAIN RESEARCH

Therapeutic Potential of Group III Metabotropic Glutamate Receptors

(2008) Hilde Lavreysen et al.   CURRENT MEDICINAL CHEMISTRY

The mGlu4 receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu6 receptors

(2008) Donald Beqollari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2AReceptor Antagonists with In Vivo Efficacy

(2008) Deborah H. Slee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antagonists of the Human A2AAdenosine Receptor. 4. Design, Synthesis, and Preclinical Evaluation of 7-Aryltriazolo[4,5-d]pyrimidines

(2008) Roger J. Gillespie et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

The clinical relevance of levodopa toxicity in the treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   MOVEMENT DISORDERS

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Multifunctional drugs as neurotherapeutics

(2008) Cornelis J. Schyf et al.   Neurotherapeutics

Dual-target-directed drugs that block monoamine oxidase B and adenosine A2A receptors for Parkinson’s disease

(2008) Jacobus P. Petzer et al.   Neurotherapeutics

Neurobiology and treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   TRENDS IN PHARMACOLOGICAL SCIENCES