Article
Medicine, Research & Experimental
Dolores Ochoa, Manuel Roman, Carmen Belmonte, Samuel Martin-Vilchez, Gina Mejia-Abril, Francisco Abad-Santos, Gonzalo Hernandez, Paula Arranz, Lorena Elgezabal, Nieves Fernandez
Summary: Bilastine, administered as an ophthalmic formulation, is minimally absorbed into the bloodstream and shows good safety profile after multiple dose administration.
ADVANCES IN THERAPY
(2021)
Review
Biology
Tom Paterson, Serap Azizoglu, Moneisha Gokhale, Madeline Chambers, Cenk Suphioglu
Summary: Anti-allergy eyedrops are widely used for treating ocular allergies, but the common preservative benzalkonium chloride may damage corneal cells and increase the risk of corneal damage, especially when there is inflammation and eye rubbing action.
Article
Allergy
P. J. Gomes, J. B. Ciolino, P. Arranz, G. Hernandez, F. Fernandez
Summary: This study evaluated the optimal dose, efficacy, and safety of a newly developed once-daily preservative-free ophthalmic formulation of bilastine for allergic conjunctivitis. The results showed that the bilastine ophthalmic formulation was effective in reducing ocular itching, with sustained efficacy up to 16 hours after treatment. It also improved nasal symptoms. The new formulation was safe and well tolerated.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Plant Sciences
Yoshimasa Sugiura, Yuta Matsuura, Hirotaka Katsuzaki, Makoto Kakinuma, Hideomi Amano, Masakatsu Usui, Ryusuke Tanaka, Teruo Matsushita, Masaaki Miyata
Summary: This study investigated the immunomodulating effect of phlorotannin in mice and found that it can reduce allergic reactions by regulating T cells and suppressing inflammatory lymphocytes.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Sherin F. Hammad, Mona M. Rady, Samah F. El-Malla
Summary: A validated and simple spectrophotometric method for simultaneous quantification of ketorolac tromethamine and olopatadine HCl in ophthalmic preparations was developed. The method showed good precision and accuracy, making it suitable for quality control analysis of samples containing both drugs.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Riku Kawasaki, Shogo Kawamura, Tomoki Kodama, Keita Yamana, Akira Maeda, Dilimulati Yimiti, Shigeru Miyaki, Shodai Hino, Naoki Ozawa, Tomoki Nishimura, Seiji Kawamoto, Atsushi Ikeda
Summary: The prevalence of allergic disorders has increased globally in recent years. Polyphenols such as resveratrol and curcumin have potential as therapeutic agents for allergy, but their usage is limited due to poor water solubility. To address this, highly concentrated, water-dispersible supramolecular complexes of polyphenols with polypeptides (poly-L-lysine, poly-gamma-glutamic acid) and gelatin were developed using high-speed vibration milling. These complexes exhibited resistance to photobleaching and thermal radiation. In vitro, treatment of a rat basophilic leukemia cell line (RBL-2H3) with polypeptide complexes containing resveratrol suppressed allergic responses. In vivo, aerosolized administration of polypeptide complexes showed excellent bioavailability and inhibition of immediate hypersensitivity reactions in ear tissue. Furthermore, this method avoids the use of organic solvents, reducing undesirable biological responses.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Allergy
Patrick Janeczko, Matthew R. Norris, Leonard Bielory
Summary: Research into drug receptor profiles for dry eye disease and allergic disorders has shown variations in affinities for histaminic and muscarinic receptors. These findings are essential for better evaluation of medication efficacy.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yoshimasa Sugiura, Yoichi Kinoshita, Shouta Misumi, Hiroaki Yamatani, Hirotaka Katsuzaki, Yuichi Hayashi, Noboru Murase
Summary: The study investigated the antiallergic effects of brown algae harvested in Japan and found seasonal variations in the active components, which correlated with changes in antiallergic effects. Monthly measurements revealed higher levels of phlorotannins and stronger antiallergic effects in summer-autumn, indicating a correlation between seasonal variation and effectiveness. Removing phlorotannins from the extracts eliminated the antiallergic effects, demonstrating their role as active components.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Editorial Material
Medicine, General & Internal
Stephanie V. Sherman, Yi-Min Huang, Pei-Hsuan Lin
Summary: A 67-year-old man presented with swollen eyelids and proptosis in the ophthalmology clinic. Biopsy of the right lacrimal gland revealed a lymphoplasmacytic infiltrate with IgG4-positive plasma cells.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Eun-Hwa Jang, Hae-Duck Bae, Yejin Jeon, Dong Hae Shin, Soosung Kang, Kyunglim Lee
Summary: In this study, we investigated nine compounds known to interact with mTCTP for their ability to suppress the activity of extracellular dTCTP. Meclizine, a piperazine-derivative antihistamine, was found to significantly reduce IL-8 release and suppress the NF-kappa B pathway. The direct interaction of meclizine with dTCTP was confirmed by surface plasmon resonance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wen Yan Huang, Sang Hoon Lee, Seong Ju Oh, Hyeock Yoon, Jeong Hoon Pan, Inhye Jeong, Mi Jeong Kim, Bok Kyung Han, Jae Kyeom Kim, Eui-Cheol Shin, Young Jun Kim
Summary: The study found that sword bean pod extract (SBP) has significant therapeutic effects on allergic asthma. SBP reduces the infiltration of inflammatory cells and decreases the release of inflammatory cytokines, thereby improving pulmonary inflammation and treating OVA/Alum-induced asthma.
Article
Veterinary Sciences
Gustav G. Bruer, Daria Goedecke, Manfred Kietzmann, Jessica Meissner
Summary: The study revealed that florfenicol treatment resulted in increased resistance in E. coli, while combination with antihistamine mepyramine lowered the minimum inhibitory concentration for other bacteria, indicating potential benefits in enhancing antibacterial efficacy and modifying effects on gut microbiota.
VETERINARY SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yoshimasa Sugiura, Masakatsu Usui, Hirotaka Katsuzaki, Kunio Imai, Ryusuke Tanaka, Teruo Matsushita, Masaaki Miyata
Summary: The study isolated dieckol from the brown alga E. nipponica, demonstrating its anti-allergic effects by suppressing the release of various bioactive molecules. With the increasing prevalence of allergies globally, dieckol could serve as a potential health food ingredient to prevent lifestyle-related diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Ophthalmology
Grant A. Justin, Fasika A. Woreta, Marcus H. Colyer, James D. Auran, Ron W. Pelton, Christopher J. Rapuano, Anne M. Menke
Summary: This study reviewed data on ophthalmic trauma malpractice claims in the United States to determine the frequency and causes of litigation. The study found that ophthalmic trauma malpractice claims are rare but result in higher payouts compared to non-trauma settlements, with approximately 40% of cases decided in favor of the plaintiff. Improvements in care could be achieved through careful history-taking, comprehensive ophthalmic examinations, appropriate imaging, meticulous documentation, and early referral to subspecialists.
Article
Chemistry, Physical
Juliane R. Santos, Loide O. Sallum, Marianna C. Silva, Antonio S. N. Aguiar, Jose L. R. Martins, Pal Perjesi, Ademir J. Camargo, Hamilton B. Napolitano
Summary: Olopatadine hydrochloride is a selective H1 receptor antagonist used to treat allergic conjunctivitis. This compound has polymorphism and understanding its physicochemical properties and solubility differences between polymorphs I and II is important. The supramolecular crystal arrangement, involving strong and weak intermolecular interactions, affects the solubility in drug polymorphs.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2023)
