Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 50, Pages 15892-15898Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b09970
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Funding
- Spanish government
- EU [FIS PI13/00089, PIS PI12/02838, FIS PI12/00956, RD12/0036/0025]
- La Marato de TV3 Foundation [20132730]
- SEPAR [17/2014]
- Consejeria de Educacion de la Junta de Castilla y Leon [BU340U13]
- Ministerio de Economia y competitividad/Instituto de Salud Carlos III [SAF2014-55700-P]
- ICREA Academia
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Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of sternness of CSCs leading to effective elimination of this cancer cell subpopulation.
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