Journal
CURRENT GENE THERAPY
Volume 14, Issue 4, Pages 300-308Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652321404140902124838
Keywords
Angiogenesis; clinical trials; gene therapy; growth factor; peripheral artery disease; plasmid
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Funding
- Health Labour Sciences Research Grant
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Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved promising results in preclinical studies and early-phase clinical trials, yet few late-phase clinical trials have been conducted or have not shown efficacy. This article provides an overview of the progression of angiogenesis research in gene therapy field as it applies to PAD. The focus of angiogenic growth factors and clinical trials is introduced as a frontier of therapeutic angiogenesis. The article also includes insights into future directions from bench to bedside.
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