Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Paving TRAIL’s Path with Ubiquitin

(2018) Elodie Lafont et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

(2017) Aruna Bitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface

(2017) Sarah E. Stewart et al.   JOURNAL OF CELL SCIENCE

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

(2017) Raffaella Iurlaro et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

(2017) Carlos R. Reis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity

(2017) Tzu-Chi Lin et al.   Oncotarget

Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1

(2017) Kyoko Matoba et al.   Cell Reports

Key regulators of galectin-glycan interactions

(2016) Nourine A. Kamili et al.   PROTEOMICS

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress

(2016) Florent Dufour et al.   Oncotarget

Galectin-1 Modulates the Survival and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Sensitivity in Human Hepatocellular Carcinoma Cells

(2015) Juan Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

NEU3 activity enhances EGFR activation without affecting EGFR expression and acts on its sialylation levels

(2015) Alessandra Mozzi et al.   GLYCOBIOLOGY

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity

(2015) L O'Leary et al.   ONCOGENE

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

(2015) Hsin-Yung Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion

(2015) A Morlé et al.   Cell Death & Disease

Releasing N-glycan from Peptide N-terminus by N-terminal Succinylation Assisted Enzymatic Deglycosylation

(2015) Yejing Weng et al.   Scientific Reports

Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity

(2014) Jonathan D. Graves et al.   CANCER CELL

Dominant Negative Effects of Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes

(2014) Simon Neumann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies

(2014) Shravan Madireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-κB

(2014) Mariam Anees et al.   LEUKEMIA & LYMPHOMA

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Systems biology of death receptor networks: live and let die

(2014) I N Lavrik   Cell Death & Disease

The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma

(2014) Ingrid A M van Roosmalen et al.   SpringerPlus

Death receptors as targets in cancer

(2013) O Micheau et al.   BRITISH JOURNAL OF PHARMACOLOGY

The chains of death

(2013) Kolja Schleich et al.   CELL CYCLE

Glycobiology of cell death: when glycans and lectins govern cell fate

(2013) R G Lichtenstein et al.   CELL DEATH AND DIFFERENTIATION

Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling

(2013) Tamas Sessler et al.   PHARMACOLOGY & THERAPEUTICS

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

Glucose—a sweet way to die

(2012) Marion MacFarlane et al.   CELL CYCLE

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis

(2012) Markus David Siegelin   EXPERT OPINION ON THERAPEUTIC TARGETS

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration

(2012) Wei Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Precise Mapping of the CD95 Pre-Ligand Assembly Domain

(2012) Valérie Edmond et al.   PLoS One

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2

(2011) Rosa Martín-Pérez et al.   APOPTOSIS

A galectin-3 sequence polymorphism confers TRAIL sensitivity to human breast cancer cells

(2011) Nachman Mazurek et al.   CANCER

Cell-surface galectin-3 confers resistance to TRAIL by impeding trafficking of death receptors in metastatic colon adenocarcinoma cells

(2011) N Mazurek et al.   CELL DEATH AND DIFFERENTIATION

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression - a case of targeted uncloaking

(2011) Joana-Tavares de Oliveira et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

GDP-mannose-4,6-dehydratase (GMDS) Deficiency Renders Colon Cancer Cells Resistant to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor- and CD95-mediated Apoptosis by Inhibiting Complex II Formation

(2011) Kenta Moriwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialylation of the Fas Death Receptor by ST6Gal-I Provides Protection against Fas-mediated Apoptosis in Colon Carcinoma Cells

(2011) Amanda F. Swindall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ST6Gal-I Regulates Macrophage Apoptosis via α2-6 Sialylation of the TNFR1 Death Receptor

(2011) Zhongyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells

(2011) J Merlin et al.   ONCOGENE

Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation

(2011) Olga M. Shatnyeva et al.   PLoS One

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

(2011) Y.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

(2011) Sarah Shirley et al.   Recent Patents on Anti-Cancer Drug Discovery

2-Deoxyglucose sensitizes melanoma cells to TRAIL-induced apoptosis which is reduced by mannose

(2010) J.-Z. Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

(2010) A Morizot et al.   CELL DEATH AND DIFFERENTIATION

Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells

(2009) Chi-Iou Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin

(2009) Hai-Yan Zhang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Deficiency of GMDS Leads to Escape from NK Cell-Mediated Tumor Surveillance Through Modulation of TRAIL Signaling

(2009) Kenta Moriwaki et al.   GASTROENTEROLOGY

2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2

(2009) Hao Liu et al.   Molecular Cancer

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor

(2008) Kazuko Matsumoto et al.   CANCER SCIENCE

Galectin-1 induced activation of the apoptotic death-receptor pathway in human Jurkat T lymphocytes

(2008) Bettina Brandt et al.   HISTOCHEMISTRY AND CELL BIOLOGY