Understanding respiratory syncytial virus (RSV) vaccine development and aspects of disease pathogenesis

The Real-Life Effectiveness of Palivizumab for Reducing Hospital Admissions for Respiratory Syncytial Virus in Infants Residing in Nunavut

(2016) Anna Banerji et al.   Canadian Respiratory Journal

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

(2015) Maximillian S. Habibi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nasal mucosal microRNA expression in children with respiratory syncytial virus infection

(2015) Christopher S Inchley et al.   BMC INFECTIOUS DISEASES

Respiratory syncytial virus in infants

(2015) Flor M. Munoz   CURRENT OPINION IN INFECTIOUS DISEASES

Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen

(2015) Bert Schepens et al.   Immunotherapy

Molecular characterization of respiratory syncytial viruses infecting children reported to have received palivizumab immunoprophylaxis

(2015) Danielle B.L. Oliveira et al.   JOURNAL OF CLINICAL VIROLOGY

Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics

(2015) E. A. F. Simoes et al.   JOURNAL OF INFECTIOUS DISEASES

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate

(2015) Bo Liang et al.   JOURNAL OF VIROLOGY

Neurotrophins and Neuropathic Pain: Role in Pathobiology

(2015) Nemat Khan et al.   MOLECULES

Biomarkers of respiratory syncytial virus (RSV) infection: specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity

(2015) Paul M. Brown et al.   Paediatric Respiratory Reviews

Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus

(2015) Abdoulaye J. Dabo et al.   PLoS One

Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease

(2015) Yu-Na Lee et al.   VIROLOGY

An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice

(2015) Seyhan Boyoglu-Barnum et al.   VIROLOGY

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

(2015) Anders Krarup et al.   Nature Communications

Animal models of respiratory syncytial virus infection and disease

(2015) Randy E Sacco et al.   Current Opinion in Virology

Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination

(2015) Hongjing Gu et al.   Human Vaccines & Immunotherapeutics

Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates

(2015) Angiolo Pierantoni et al.   Molecular Therapy-Methods & Clinical Development

A Novel Respiratory Syncytial Virus (RSV) F Subunit Vaccine Adjuvanted with GLA-SE Elicits Robust Protective TH1-Type Humoral and Cellular Immunity In Rodent Models

(2015) Stacie L. Lambert et al.   PLoS One

miRNA biogenesis: Biological impact in the development of cancer

(2014) Sandra L Romero-Cordoba et al.   CANCER BIOLOGY & THERAPY

Maternal Immunization

(2014) H. Y. Chu et al.   CLINICAL INFECTIOUS DISEASES

Current concepts and progress in RSV vaccine development

(2014) Aleks K Guvenel et al.   Expert Review of Vaccines

Challenges in developing a pediatric RSV vaccine

(2014) Jeanne H. Schickli et al.   Human vaccines & immunotherapeutics

Lamb Model of Respiratory Syncytial Virus-Associated Lung Disease: Insights to Pathogenesis and Novel Treatments

(2014) M. R. Ackermann   ILAR JOURNAL

IL-13 Is Required for Eosinophil Entry into the Lung during Respiratory Syncytial Virus Vaccine-Enhanced Disease

(2014) E. M. Castilow et al.   JOURNAL OF IMMUNOLOGY

Respiratory Syncytial Virus Transplacental Antibody Transfer and Kinetics in Mother-Infant Pairs in Bangladesh

(2014) Helen Y. Chu et al.   JOURNAL OF INFECTIOUS DISEASES

Structural Analysis of Respiratory Syncytial Virus Reveals the Position of M2-1 between the Matrix Protein and the Ribonucleoprotein Complex

(2014) G. Kiss et al.   JOURNAL OF VIROLOGY

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of Safe and Effective RSV Vaccine by Modified CD4 Epitope in G Protein Core Fragment (Gcf)

(2014) In Su Cheon et al.   PLoS One

A Novel Six Consecutive Monthly Doses of Palivizumab Prophylaxis Protocol for the Prevention of Respiratory Syncytial Virus Infection in High-Risk Preterm Infants in Taiwan

(2014) Hsin Chi et al.   PLoS One

Vaccine Safety and Efficacy Evaluation of a Recombinant Bovine Respiratory Syncytial Virus (BRSV) with Deletion of the SH Gene and Subunit Vaccines Based On Recombinant Human RSV Proteins: N-nanorings, P and M2-1, in Calves with Maternal Antibodies

(2014) Krister Blodörn et al.   PLoS One

Respiratory Syncytial Virus Human Experimental Infection Model: Provenance, Production, and Sequence of Low-Passaged Memphis-37 Challenge Virus

(2014) Young-In Kim et al.   PLoS One

An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization

(2014) Rama Raghunandan et al.   VACCINE

Serum palivizumab level is associated with decreased severity of respiratory syncytial virus disease in high-risk infants

(2014) Michael L Forbes et al.   Human Vaccines & Immunotherapeutics

Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A

(2013) Hiroto Matsuse et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells

(2013) Satoshi Hirakawa et al.   JOURNAL OF MEDICAL VIROLOGY

Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection

(2013) Ross B. Fulton et al.   JOURNAL OF VIROLOGY

A Novel Influenza Virus Hemagglutinin-Respiratory Syncytial Virus (RSV) Fusion Protein Subunit Vaccine against Influenza and RSV

(2013) T. M. Turner et al.   JOURNAL OF VIROLOGY

A Respiratory Syncytial Virus (RSV) Anti-G Protein F(ab')2 Monoclonal Antibody Suppresses Mucous Production and Breathing Effort in RSV rA2-line19F-Infected BALB/c Mice

(2013) S. Boyoglu-Barnum et al.   JOURNAL OF VIROLOGY

Vertical Transmission of Respiratory Syncytial Virus Modulates Pre- and Postnatal Innervation and Reactivity of Rat Airways

(2013) Giovanni Piedimonte et al.   PLoS One

Nanoparticle Vaccines Encompassing the Respiratory Syncytial Virus (RSV) G Protein CX3C Chemokine Motif Induce Robust Immunity Protecting from Challenge and Disease

(2013) Patricia A. Jorquera et al.   PLoS One

Effects of Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) in the Perinatal Lamb Model of RSV

(2013) Rachel J. Derscheid et al.   PLoS One

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Respiratory syncytial virus vaccine development

(2013) Larry J. Anderson   SEMINARS IN IMMUNOLOGY

Impact of maternal characteristics on the effect of maternal influenza vaccination on fetal outcomes

(2013) Demilade A. Adedinsewo et al.   VACCINE

Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein

(2012) Anu Cherukuri et al.   Clinical and Vaccine Immunology

Importance of Timing of Maternal Combined Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Immunization and Protection of Young Infants

(2012) C. Mary Healy et al.   CLINICAL INFECTIOUS DISEASES

Innate Immune Dysfunction is Associated with Enhanced Disease Severity In Infants with Severe Respiratory Syncytial Virus Bronchiolitis

(2012) Cesar Mella et al.   JOURNAL OF INFECTIOUS DISEASES

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

(2012) Nandini Krishnamoorthy et al.   NATURE MEDICINE

CD4+ T-cell counts and interleukin-8 and CCL-5 plasma concentrations discriminate disease severity in children with RSV infection

(2012) Hanne K. Brand et al.   PEDIATRIC RESEARCH

Differential Expression of Cytokines in Response to Respiratory Syncytial Virus Infection of Calves with High or Low Circulating 25-Hydroxyvitamin D3

(2012) Randy E. Sacco et al.   PLoS One

Respiratory Syncytial Virus Fusion Glycoprotein Expressed in Insect Cells Form Protein Nanoparticles That Induce Protective Immunity in Cotton Rats

(2012) Gale Smith et al.   PLoS One

Combination Therapy Using Monoclonal Antibodies against Respiratory Syncytial Virus (RSV) G Glycoprotein Protects from RSV Disease in BALB/c Mice

(2012) Hayat Caidi et al.   PLoS One

Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine

(2012) Gregory M. Glenn et al.   VACCINE

Animal models of human respiratory syncytial virus disease

(2011) Reinout A. Bem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Assessment of IgE response and cytokine gene expression in pulmonary efferent lymph collected after ovalbumin inhalation during experimental infection of calves with bovine respiratory syncytial virus

(2011) Laurel J. Gershwin et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

The Tonsils Revisited: Review of the Anatomical Localization and Histological Characteristics of the Tonsils of Domestic and Laboratory Animals

(2011) Christophe Casteleyn et al.   Clinical & Developmental Immunology

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

(2011) J. S. McLellan et al.   JOURNAL OF VIROLOGY

Bring on the biomarkers

(2011) George Poste   NATURE

Aging and Immune Function: Molecular Mechanisms to Interventions

(2010) Subramaniam Ponnappan et al.   ANTIOXIDANTS & REDOX SIGNALING

Biological challenges and technological opportunities for respiratory syncytial virus vaccine development

(2010) Barney S. Graham   IMMUNOLOGICAL REVIEWS

Efficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection

(2010) K. M. Cautivo et al.   JOURNAL OF IMMUNOLOGY

Neutralization of Human Respiratory Syncytial Virus Infectivity by Antibodies and Low-Molecular-Weight Compounds Targeted against the Fusion Glycoprotein

(2010) M. Magro et al.   JOURNAL OF VIROLOGY

Prophylactic Treatment with a G Glycoprotein Monoclonal Antibody Reduces Pulmonary Inflammation in Respiratory Syncytial Virus (RSV)-Challenged Naive and Formalin-Inactivated RSV-Immunized BALB/c Mice

(2010) G. U. Radu et al.   JOURNAL OF VIROLOGY

The cotton rat model of respiratory viral infections

(2009) Marina S. Boukhvalova et al.   BIOLOGICALS

The host response and molecular pathogenesis associated with respiratory syncytial virus infection

(2009) Christine M Oshansky et al.   Future Microbiology

Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in mice

(2009) C. Miao et al.   JOURNAL OF GENERAL VIROLOGY

Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients

(2009) E. J. Collarini et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Monoclonal Antibody Treatment Targeting Respiratory Syncytial Virus (RSV) G Protein Mediates Viral Clearance and Reduces the Pathogenesis of RSV Infection in BALB/c Mice

(2009) Lia M. Haynes et al.   JOURNAL OF INFECTIOUS DISEASES

Lethal pneumonia in a captive juvenile chimpanzee (Pan troglodytes) due to human-transmitted human respiratory syncytial virus (HRSV) and infection withStreptococcus pneumoniae

(2009) Claudia A. Szentiks et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Vaccination To Induce Antibodies Blocking the CX3C-CX3CR1 Interaction of Respiratory Syncytial Virus G Protein Reduces Pulmonary Inflammation and Virus Replication in Mice

(2009) W. Zhang et al.   JOURNAL OF VIROLOGY

Vaccines: Correlates of Vaccine‐Induced Immunity

(2008) Stanley A. Plotkin   CLINICAL INFECTIOUS DISEASES

Safety and efficacy of neonatal vaccination

(2008) Alicia Demirjian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Young Infants Can Develop Protective Levels of Neutralizing Antibody after Infection with Respiratory Syncytial Virus

(2008) Joshua J. Shinoff et al.   JOURNAL OF INFECTIOUS DISEASES

Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines— Nonadjuvanted Vaccine or Vaccine Adjuvanted with Alum—Given Concomitantly with Influenza Vaccine to High‐Risk Elderly Individuals

(2008) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

Respiratory Syncytial Virus Activates Innate Immunity through Toll-Like Receptor 2

(2008) M. R. Murawski et al.   JOURNAL OF VIROLOGY

Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4

(2008) Kayleen S. Kott et al.   PEDIATRIC PULMONOLOGY

Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG

(2008) S. M. Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain

(2008) Siok Wan Gan et al.   PROTEIN SCIENCE