UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans

How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude

(2017) Katie Podshivalova et al.   Cell Reports

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Does Longer Lifespan Mean Longer Healthspan?

(2016) Malene Hansen et al.   TRENDS IN CELL BIOLOGY

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

(2016) Ineke Dhondt et al.   Cell Reports

Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health

(2016) William B. Zhang et al.   Cell Systems

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

(2016) Saroj G. Regmi et al.   Aging-US

Ultra-structural time-course study in theC. elegansmodel for Duchenne muscular dystrophy highlights a crucial role for sarcomere-anchoring structures and sarcolemma integrity in the earliest steps of the muscle degeneration process

(2015) Nicolas Brouilly et al.   HUMAN MOLECULAR GENETICS

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Uncoupling lifespan and healthspan inCaenorhabditis eleganslongevity mutants

(2015) Ankita Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

(2015) Jeong-Hoon Hahm et al.   Nature Communications

Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome

(2014) Vanessa Liang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39

(2014) Marion Manil-Ségalen et al.   DEVELOPMENTAL CELL

Autophagy Impairment in Muscle Induces Neuromuscular Junction Degeneration and Precocious Aging

(2014) Silvia Carnio et al.   Cell Reports

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics

(2013) Emanuele Marzetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Functional Aging in the Nervous System Contributes to Age-Dependent Motor Activity Decline in C. elegans

(2013) Jie Liu et al.   Cell Metabolism

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

(2013) F. Demontis et al.   Disease Models & Mechanisms

Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy

(2013) Jean Giacomotto et al.   HUMAN MOLECULAR GENETICS

Reduced Insulin/Insulin-like Growth Factor-1 Signaling and Dietary Restriction Inhibit Translation but Preserve Muscle Mass inCaenorhabditis elegans

(2013) Geert Depuydt et al.   MOLECULAR & CELLULAR PROTEOMICS

Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy

(2013) K. H. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Transcription factor redundancy and tissue-specific regulation: Evidence from functional and physical network connectivity

(2012) S. G. Kuntz et al.   GENOME RESEARCH

Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromuscular junction that are modified by reduced insulin signalling

(2012) B. Mulcahy et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

(2011) Matthew D. McGee et al.   AGING CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-γ, and IP3R activation

(2010) Hiroaki Iwasa et al.   AGING CELL

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

A Widespread Distribution of Genomic CeMyoD Binding Sites Revealed and Cross Validated by ChIP-Chip and ChIP-Seq Techniques

(2010) Haiyan Lei et al.   PLoS One

An Integrated Strategy to Study Muscle Development and Myofilament Structure in Caenorhabditis elegans

(2009) Barbara Meissner et al.   PLoS Genetics

Premature Aging in Skeletal Muscle Lacking Serum Response Factor

(2008) Charlotte Lahoute et al.   PLoS One

A Novel Role for the SMG-1 Kinase in Lifespan and Oxidative Stress Resistance in Caenorhabditis elegans

(2008) Ingrid Masse et al.   PLoS One

DYC-1, a Protein Functionally Linked to Dystrophin in Caenorhabditis elegans Is Associated with the Dense Body, Where It Interacts with the Muscle LIM Domain Protein ZYX-1

(2007) Claire Lecroisey et al.   MOLECULAR BIOLOGY OF THE CELL