Journal
MOLECULES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules22091403
Keywords
DOTA-TBIA101; depsipeptides; infection; inflammation; tuberculosis; Ga-68/Ge-68 generator; PET/CT imaging
Funding
- Department of Science and Technology (DST)
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The study assessed a radiolabeled depsipeptide conjugate (Ga-68-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. Ga-68-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2) rabbits bearing muscular sterile inflammation and Staphylococcus aureus (SA) infection; and (NZR3) rabbits infected with Mycobacterium tuberculosis (MTB) combined with a subcutaneous scruff infection of SA in the same animal. All animals were imaged using a PET/CT scanner at 5 and 60 min post injection. Images showed elevated accumulation of 68Ga-DOTA-TBIA101 in the sterile muscular inflammation site (T/NT ratio = 2.6 +/- 0.37 (5 min) and 2.8 +/- 2.3 (60 min)) and muscles infected with MTB (T/NT ratio = 2.6 +/- 0.35 (5 min) and 2.8 +/- 0.16 (60 min)). The findings suggest that Ga-68-DOTA-TBIA101-PET/CT may detect MTB-associated inflammation, although more foundational studies need to be performed to rationalize the diagnostic value of this technique.
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