Adenoviral vector-based strategies against infectious disease and cancer

Chimpanzee Adenovirus Vector Ebola Vaccine

(2017) Julie E. Ledgerwood et al.   NEW ENGLAND JOURNAL OF MEDICINE

The induction of antigen-specific CTL by in situ Ad-REIC gene therapy

(2016) Y Ariyoshi et al.   GENE THERAPY

Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial

(2016) Milagritos D Tapia et al.   LANCET INFECTIOUS DISEASES

Intranasal immunization with an adenovirus vaccine protects guinea pigs from Ebola virus transmission by infected animals

(2015) Gary Wong et al.   ANTIVIRAL RESEARCH

In vitro antitumor immune response induced by dendritic cells transduced with human livin α recombinant adenovirus

(2015) Junping Xie et al.   CELLULAR IMMUNOLOGY

Adenovirus-mediated artificial MicroRNAs targeting matrix or nucleoprotein genes protect mice against lethal influenza virus challenge

(2015) H Zhang et al.   GENE THERAPY

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

(2015) Xiaojuan Guo et al.   IMMUNOLOGY

Adenovirus-Vectored Vaccine Provides Postexposure Protection to Ebola Virus–Infected Nonhuman Primates

(2015) Gary Wong et al.   JOURNAL OF INFECTIOUS DISEASES

High titre neutralising antibodies to influenza after oral tablet immunisation: a phase 1, randomised, placebo-controlled trial

(2015) David Liebowitz et al.   LANCET INFECTIOUS DISEASES

Single-Molecule Analysis of the Target Cleavage Reaction by the Drosophila RNAi Enzyme Complex

(2015) Chunyan Yao et al.   MOLECULAR CELL

Oral Priming with Replicating Adenovirus Serotype 4 Followed by Subunit H5N1 Vaccine Boost Promotes Antibody Affinity Maturation and Expands H5N1 Cross-Clade Neutralization

(2015) Surender Khurana et al.   PLoS One

Combination recombinant simian or chimpanzee adenoviral vectors for vaccine development

(2015) Cheng Cheng et al.   VACCINE

The relative magnitude of transgene-specific adaptive immune responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species

(2015) Matthew D.J. Dicks et al.   VACCINE

Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71

(2015) Chao Zhang et al.   VACCINE

Recent developments in clinical trial designs for HIV vaccine research

(2015) Laura Richert et al.   Human Vaccines & Immunotherapeutics

Centralized Consensus Hemagglutinin Genes Induce Protective Immunity against H1, H3 and H5 Influenza Viruses

(2015) Richard J. Webby et al.   PLoS One

A Replicating Adenovirus Capsid Display Recombinant Elicits Antibodies against Plasmodium falciparum Sporozoites in Aotus nancymaae Monkeys

(2014) Kasey A. Karen et al.   INFECTION AND IMMUNITY

Induction of HIV-1–Specific Mucosal Immune Responses Following Intramuscular Recombinant Adenovirus Serotype 26 HIV-1 Vaccination of Humans

(2014) Lindsey R. Baden et al.   JOURNAL OF INFECTIOUS DISEASES

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

(2014) Eun Kim et al.   VACCINE

Protection of non-human primates against rabies with an adenovirus recombinant vaccine

(2014) Z.Q. Xiang et al.   VIROLOGY

Neutralizing antibody responses to enterovirus and adenovirus in healthy adults in China

(2014) Xiang Wang et al.   Emerging Microbes & Infections

Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models

(2014) Yudan Chi et al.   Molecular Therapy-Nucleic Acids

Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma

(2013) Misato Takagi-Kimura et al.   CANCER SCIENCE

Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study

(2013) Marc Gurwith et al.   LANCET INFECTIOUS DISEASES

Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial

(2013) Manfred Westphal et al.   LANCET ONCOLOGY

Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1

(2013) Robert Schwenk et al.   MALARIA JOURNAL

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

(2013) Ilin Chuang et al.   PLoS One

Adenovirus-Based Vaccine with Epitopes Incorporated in Novel Fiber Sites to Induce Protective Immunity against Pseudomonas aeruginosa

(2013) Anurag Sharma et al.   PLoS One

Broadly Protective Adenovirus-Based Multivalent Vaccines against Highly Pathogenic Avian Influenza Viruses for Pandemic Preparedness

(2013) Sai V. Vemula et al.   PLoS One

A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

(2013) Alphonse Ouédraogo et al.   PLoS One

A Human Type 5 Adenovirus-Based Tuberculosis Vaccine Induces Robust T Cell Responses in Humans Despite Preexisting Anti-Adenovirus Immunity

(2013) F. Smaill et al.   Science Translational Medicine

Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

(2013) Wendy Peters et al.   VACCINE

Human adenovirus 5-vectoredPlasmodium falciparumNMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection

(2013) Cindy Tamminga et al.   Human Vaccines & Immunotherapeutics

HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice

(2012) S H MacLeod et al.   CANCER GENE THERAPY

First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine (IPCAVD 001)

(2012) Lindsey R. Baden et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)

(2012) Dan H. Barouch et al.   JOURNAL OF INFECTIOUS DISEASES

Comparative Analysis of Simian Immunodeficiency Virus Gag-Specific Effector and Memory CD8+T Cells Induced by Different Adenovirus Vectors

(2012) Wendy G. Tan et al.   JOURNAL OF VIROLOGY

Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys

(2012) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

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(2012) Sayma Rahman et al.   MOLECULAR MEDICINE

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

(2012) Susanne H Sheehy et al.   MOLECULAR THERAPY

Hexon-modified Recombinant E1-deleted Adenovirus Vectors as Dual Specificity Vaccine Carriers for Influenza Virus

(2012) Dongming Zhou et al.   MOLECULAR THERAPY

Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon

(2012) Xingui Tian et al.   PLoS One

MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load

(2012) Holly Janes et al.   PLoS One

A Phase I Double Blind, Placebo-Controlled, Randomized Study of a Multigenic HIV-1 Adenovirus Subtype 35 Vector Vaccine in Healthy Uninfected Adults

(2012) Michael C. Keefer et al.   PLoS One

Adenovirus receptors: implications for targeting of viral vectors

(2012) Niklas Arnberg   TRENDS IN PHARMACOLOGICAL SCIENCES

A recombinant adenovirus expressing immunodominant TB antigens can significantly enhance BCG-induced human immunity

(2012) Daniel F. Hoft et al.   VACCINE

Adenoviral protein V promotes a process of viral assembly through nucleophosmin 1

(2012) Hideyo Ugai et al.   VIROLOGY

Evolution of oncolytic adenovirus for cancer treatment

(2011) Joung-Woo Choi et al.   ADVANCED DRUG DELIVERY REVIEWS

Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine

(2011) Nicole Frahm et al.   JOURNAL OF CLINICAL INVESTIGATION

Computational Analysis of Two Species C Human Adenoviruses Provides Evidence of a Novel Virus

(2011) M. P. Walsh et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Adenovirus Core Protein VII Protects the Viral Genome from a DNA Damage Response at Early Times after Infection

(2011) K. A. Karen et al.   JOURNAL OF VIROLOGY

Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

(2011) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

A Single Sublingual Dose of an Adenovirus-Based Vaccine Protects against Lethal Ebola Challenge in Mice and Guinea Pigs

(2011) Jin Huk Choi et al.   MOLECULAR PHARMACEUTICS

CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

(2011) Nancy J Sullivan et al.   NATURE MEDICINE

A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204)

(2011) Gavin J. Churchyard et al.   PLoS One

Head and neck cancer: Response to p53-based therapeutics

(2010) Jackie Nemunaitis et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

(2010) Emma C Nilsson et al.   NATURE MEDICINE

Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses

(2010) Richard A. Koup et al.   PLoS One

Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

(2010) H. Liu et al.   SCIENCE

A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults

(2010) J.E. Ledgerwood et al.   VACCINE

Canine adenoviruses elicit both humoral and cell-mediated immune responses against rabies following immunisation of sheep

(2010) Coraline Bouet-Cararo et al.   VACCINE

Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors

(2010) Jeroen de Vrij et al.   VIROLOGY

Overview of STEP and Phambili trial results: two phase IIb test-of-concept studies investigating the efficacy of MRK adenovirus type 5 gag/pol/nef subtype B HIV vaccine

(2010) Glenda Gray et al.   Current Opinion in HIV and AIDS

A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry

(2010) Harald Wodrich et al.   PLoS Pathogens

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

(2009) J. Nemunaitis et al.   CLINICAL CANCER RESEARCH

New Insights on Adenovirus as Vaccine Vectors

(2009) Marcio O Lasaro et al.   MOLECULAR THERAPY

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

(2009) A. Benlahrech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An adenovirus type 5 (AdV5) vector encoding an envelope domain III-based tetravalent antigen elicits immune responses against all four dengue viruses in the presence of prior AdV5 immunity

(2009) Saima Khanam et al.   VACCINE

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Localization of the N-Terminus of Minor Coat Protein IIIa in the Adenovirus Capsid

(2008) Carmen San Martín et al.   JOURNAL OF MOLECULAR BIOLOGY

Latent Species C Adenoviruses in Human Tonsil Tissues

(2008) C. T. Garnett et al.   JOURNAL OF VIROLOGY

A Tetravalent Dengue Vaccine Based on a Complex Adenovirus Vector Provides Significant Protection in Rhesus Monkeys against All Four Serotypes of Dengue Virus

(2008) K. Raviprakash et al.   JOURNAL OF VIROLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

AAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer

(2008) B. Nie et al.   MOLECULAR CANCER THERAPEUTICS

Insights into adenovirus host cell interactions from structural studies

(2008) G.R. Nemerow et al.   VIROLOGY

Serum-free transient protein production system based on adenoviral vector and PER.C6 technology: High yield and preserved bioactivity

(2007) M.J.E. Havenga et al.   BIOTECHNOLOGY AND BIOENGINEERING