A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2

Modeling human adaptive immune responses with tonsil organoids

(2021) Lisa E. Wagar et al.   NATURE MEDICINE

B Cell Response to Vaccination

(2021) Wei Luo et al.   IMMUNOLOGICAL INVESTIGATIONS

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

(2021) Prabhu S. Arunachalam et al.   NATURE

Quadrivalent influenza nanoparticle vaccines induce broad protection

(2021) Seyhan Boyoglu-Barnum et al.   NATURE

Emerging concepts in the science of vaccine adjuvants

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New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications

(2021) Salim S. Abdool Karim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates

(2021) Maria Pino et al.   Science Immunology

Predominance of central memory T cells with high T-cell receptor repertoire diversity is associated with response to PD-1/PD-L1 inhibition in Merkel cell carcinoma

(2020) Ivelina Spassova et al.   CLINICAL CANCER RESEARCH

Reproducibility of Methods to Detect Differentially Expressed Genes from Single-Cell RNA Sequencing

(2020) Tian Mou et al.   Frontiers in Genetics

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

(2020) Prabhu S. Arunachalam et al.   NATURE MEDICINE

Factors in B cell competition and immunodominance

(2020) Robert K. Abbott et al.   IMMUNOLOGICAL REVIEWS

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates

(2020) Sudhir Pai Kasturi et al.   Science Immunology

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge

(2020) Kier Om et al.   PLoS Pathogens

Linking signaling and selection in the germinal center

(2019) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Meeting report: Convening on the influenza human viral challenge model for universal influenza vaccines, Part 1: Value; challenge virus selection; regulatory, industry and ethical considerations; increasing standardization, access and capacity

(2019) Bruce L. Innis et al.   VACCINE

Adjuvant effect of TLR7 agonist adsorbed on aluminum hydroxide (AS37): A phase I randomized, dose escalation study of an AS37-adjuvanted meningococcal C conjugated vaccine

(2019) Antonio Gonzalez-Lopez et al.   CLINICAL IMMUNOLOGY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

(2018) Hyon-Xhi Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem

(2017) Colin Havenar-Daughton et al.   IMMUNOLOGICAL REVIEWS

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

(2017) Charles Sinclair et al.   SCIENCE

Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates

(2017) Alison J. Carey et al.   Frontiers in Immunology

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

(2016) Christopher B. Fox et al.   JOURNAL OF CONTROLLED RELEASE

Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques

(2016) Sudhir Pai Kasturi et al.   JOURNAL OF VIROLOGY

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

(2016) Qian Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Synthesis and Biomedical Applications of Functional Poly(α-hydroxy acids) via Ring-Opening Polymerization of O-Carboxyanhydrides

(2015) Qian Yin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Germinal Center Selection and the Antibody Response to Influenza

(2015) Gabriel D. Victora et al.   CELL

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus

(2015) Louis M. Schwartzman et al.   mBio

Advances in aluminum hydroxide-based adjuvant research and its mechanism

(2015) Peng He et al.   Human Vaccines & Immunotherapeutics

An improved nonparametric lower bound of species richness via a modified good-turing frequency formula

(2014) Chun-Huo Chiu et al.   BIOMETRICS

Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection

(2014) V. V. A. Mallajosyula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

(2014) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

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Drug-Initiated Ring-Opening Polymerization of O-Carboxyanhydrides for the Preparation of Anticancer Drug–Poly(O-carboxyanhydride) Nanoconjugates

(2013) Qian Yin et al.   BIOMACROMOLECULES

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

The use of Toll-like receptor 7/8 agonists as vaccine adjuvants

(2013) John P Vasilakos et al.   Expert Review of Vaccines

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Immunodominance: A pivotal principle in host response to viral infections

(2012) Ali Akram et al.   CLINICAL IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines

(2011) S. Khurana et al.   Science Translational Medicine

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Influenza virus-like particle vaccines

(2009) Joel R Haynes   Expert Review of Vaccines

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH