The neurons that restore walking after paralysis

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

(2022) Andreas Rowald et al.   NATURE MEDICINE

Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease

(2021) Lyandysha V. Zholudeva et al.   JOURNAL OF NEUROSCIENCE

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

(2021) Jordan W. Squair et al.   NATURE

Robust decomposition of cell type mixtures in spatial transcriptomics

(2021) Dylan M. Cable et al.   NATURE BIOTECHNOLOGY

Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets

(2021) Peter J. Osseward et al.   SCIENCE

Prioritization of cell types responsive to biological perturbations in single-cell data with Augur

(2021) Jordan W. Squair et al.   Nature Protocols

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

(2021) Claudia Kathe et al.   NATURE BIOTECHNOLOGY

Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram

(2021) Tommaso Biancalani et al.   NATURE METHODS

A harmonized atlas of mouse spinal cord cell types and their spatial organization

(2021) Daniel E. Russ et al.   Nature Communications

Confronting false discoveries in single-cell differential expression

(2021) Jordan W. Squair et al.   Nature Communications

Rapid mesoscale volumetric imaging of neural activity with synaptic resolution

(2020) Rongwen Lu et al.   NATURE METHODS

Cell type prioritization in single-cell data

(2020) Michael A. Skinnider et al.   NATURE BIOTECHNOLOGY

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

(2019) Thomas H. Hutson et al.   Science Translational Medicine

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Spinal cord repair: advances in biology and technology

(2019) Grégoire Courtine et al.   NATURE MEDICINE

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue

(2019) Fabian F. Voigt et al.   NATURE METHODS

Toward a Common Coordinate Framework for the Human Body

(2019) Jennifer E. Rood et al.   CELL

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

(2018) Leonie Asboth et al.   NATURE NEUROSCIENCE

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

(2018) Marito Hayashi et al.   NEURON

Connecting neuronal circuits for movement

(2018) Silvia Arber et al.   SCIENCE

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

(2018) Pierre Yger et al.   eLife

Clustering trees: a visualisation for evaluating clusterings at multiple resolutions

(2018) Luke Zappia et al.   GigaScience

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

(2018) Megan L. Gill et al.   NATURE MEDICINE

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

(2018) Marco Capogrosso et al.   Nature Protocols

Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury

(2018) Claudia A. Angeli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted neurotechnology restores walking in humans with spinal cord injury

(2018) Fabien B. Wagner et al.   NATURE

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

(2018) Emanuele Formento et al.   NATURE NEUROSCIENCE

Connecting Circuits for Supraspinal Control of Locomotion

(2018) Manuel J. Ferreira-Pinto et al.   NEURON

Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

(2017) Sinisa Hrvatin et al.   NATURE NEUROSCIENCE

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

(2017) Jean-Baptiste Mignardot et al.   Science Translational Medicine

Motor recovery after activity-based training with spinal cord epidural stimulation in a chronic motor complete paraplegic

(2017) Enrico Rejc et al.   Scientific Reports

Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

(2016) Jay B. Bikoff et al.   CELL

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

A neurorobotic platform for locomotor prosthetic development in rats and mice

(2016) Joachim von Zitzewitz et al.   Journal of Neural Engineering

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

(2016) Marco Capogrosso et al.   NATURE

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

(2016) Nikolaus Wenger et al.   NATURE MEDICINE

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

(2016) Chenchen Pan et al.   NATURE METHODS

Decoding the organization of spinal circuits that control locomotion

(2016) Ole Kiehn   NATURE REVIEWS NEUROSCIENCE

Targeting Lumbar Spinal Neural Circuitry by Epidural Stimulation to Restore Motor Function After Spinal Cord Injury

(2016) Karen Minassian et al.   Neurotherapeutics

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Nuclear RNA-seq of single neurons reveals molecular signatures of activation

(2016) Benjamin Lacar et al.   Nature Communications

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

(2014) Aya Takeoka et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Skilled reaching relies on a V2a propriospinal internal copy circuit

(2014) Eiman Azim et al.   NATURE

Brainstem nucleus MdV mediates skilled forelimb motor tasks

(2014) Maria Soledad Esposito et al.   NATURE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

V1 and V2b Interneurons Secure the Alternating Flexor-Extensor Motor Activity Mice Require for Limbed Locomotion

(2014) Jingming Zhang et al.   NEURON

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

(2013) Janine Beauparlant et al.   BRAIN

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

(2013) M. Capogrosso et al.   JOURNAL OF NEUROSCIENCE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

RNA-sequencing from single nuclei

(2013) R. V. Grindberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

(2012) R. van den Brand et al.   SCIENCE

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

International standards for neurological classification of spinal cord injury (Revised 2011)

(2011) Steven C. Kirshblum et al.   JOURNAL OF SPINAL CORD MEDICINE

Pattern of 18F-FDG Uptake in the Spinal Cord in Patients With Non-Central Nervous System Malignancy

(2011) Bao H. Do et al.   SPINE

Functional organization of V2a-related locomotor circuits in the rodent spinal cord

(2010) Kimberly J. Dougherty et al.   Annals of the New York Academy of Sciences

Electrophysiological Characterization of V2a Interneurons and Their Locomotor-Related Activity in the Neonatal Mouse Spinal Cord

(2010) G. Zhong et al.   JOURNAL OF NEUROSCIENCE

Firing and Cellular Properties of V2a Interneurons in the Rodent Spinal Cord

(2010) K. J. Dougherty et al.   JOURNAL OF NEUROSCIENCE

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Modification of glucose metabolism in radiation-induced brain injury areas using cervical spinal cord stimulation

(2009) Bernardino Clavo et al.   ACTA NEUROCHIRURGICA

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

(2009) Grégoire Courtine et al.   NATURE NEUROSCIENCE

Circuits controlling vertebrate locomotion: moving in a new direction

(2009) Martyn Goulding   NATURE REVIEWS NEUROSCIENCE

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY