On-demand cell-autonomous gene therapy for brain circuit disorders

Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions

(2022) Clara Zourray et al.   Frontiers in Molecular Neuroscience

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease

(2022) Natalie A. Hager et al.   Frontiers in Cell and Developmental Biology

Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy

(2021) Jenna C. Carpenter et al.   EPILEPSIA

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

(2021) Joanne Ng et al.   Science Translational Medicine

In vitro ictogenesis is stochastic at the single neuron level

(2021) Lauren A Lau et al.   BRAIN

Paroxysmal Movement Disorders

(2021) Susan Harvey et al.   Frontiers in Neurology

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

(2021) Cosimo Prestigio et al.   eLife

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs

(2021) Peter J. West et al.   EXPERIMENTAL NEUROLOGY

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

(2020) Gaia Colasante et al.   BRAIN

Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

(2020) Magdalena Przybyla et al.   BRAIN

Functionally Distinct Neuronal Ensembles within the Memory Engram

(2020) Xiaochen Sun et al.   CELL

Homeostatic Plasticity in Epilepsy

(2020) Gabriele Lignani et al.   Frontiers in Cellular Neuroscience

Recent advances in gene therapy for neurodevelopmental disorders with epilepsy

(2020) Thomas J. Turner et al.   JOURNAL OF NEUROCHEMISTRY

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

(2019) Vincent Magloire et al.   Nature Communications

Epilepsy gene therapy using an engineered potassium channel

(2019) Albert Snowball et al.   JOURNAL OF NEUROSCIENCE

PTZ-induced seizures in mice require a revised Racine scale

(2019) Jan Van Erum et al.   EPILEPSY & BEHAVIOR

dCas9-based Scn1a gene activation restores inhibitory interneuron excitability and attenuates seizures in Dravet syndrome mice

(2019) Gaia Colasante et al.   MOLECULAR THERAPY

Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis

(2019) Maureen McHugo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Biochemical autoregulatory gene therapy for focal epilepsy

(2018) Andreas Lieb et al.   NATURE MEDICINE

Building three-dimensional human brain organoids

(2018) Sergiu Paşca   NATURE NEUROSCIENCE

Gene therapy and editing: Novel potential treatments for neuronal channelopathies

(2018) R.C. Wykes et al.   NEUROPHARMACOLOGY

Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

(2018) Francisco T. Gallo et al.   Frontiers in Behavioral Neuroscience

Generation and assembly of human brain region–specific three-dimensional cultures

(2018) Steven A. Sloan et al.   Nature Protocols

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

Unilateral ex vivo gene therapy by GDNF in epileptic rats

(2018) Avtandil Nanobashvili et al.   GENE THERAPY

Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior

(2018) Ee-Lynn Yap et al.   NEURON

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

(2018) Eugenio F. Fornasiero et al.   Nature Communications

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Pathophysiology of Migraine: A Disorder of Sensory Processing

(2017) Peter J. Goadsby et al.   PHYSIOLOGICAL REVIEWS

Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization

(2017) Umesh Vivekananda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reliable and Elastic Propagation of Cortical Seizures In Vivo

(2017) Michael Wenzel et al.   Cell Reports

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

Action potential broadening in a presynaptic channelopathy

(2016) Rahima Begum et al.   Nature Communications

A robust activity marking system for exploring active neuronal ensembles

(2016) Andreas T Sørensen et al.   eLife

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

A cell-based sensor of fluid shear stress for microfluidics

(2015) Sarvesh Varma et al.   LAB ON A CHIP

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys

(2015) Vanessa N. Barros et al.   Frontiers in Cellular Neuroscience

Genetically induced dysfunctions of Kir2.1 channels: implications for short QT3 syndrome and autism–epilepsy phenotype

(2014) Elena Ambrosini et al.   HUMAN MOLECULAR GENETICS

Nucleosome-specific, Time-dependent Changes in Histone Modifications during Activation of the Early Growth Response 1 (Egr1) Gene

(2014) Ángela L. Riffo-Campos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's Disease, the Subthalamic Nucleus, Inhibition, and Impulsivity

(2014) Marjan Jahanshahi et al.   MOVEMENT DISORDERS

Gene therapy in epilepsy—is it time for clinical trials?

(2014) Dimitri M. Kullmann et al.   Nature Reviews Neurology

Neural Circuit Reprogramming: A New Paradigm for Treating Neuropsychiatric Disease?

(2014) Kay M. Tye   NEURON

Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval

(2014) Kazumasa Z. Tanaka et al.   NEURON

A new era for functional labeling of neurons: activity-dependent promoters have come of age

(2014) Takashi Kawashima et al.   Frontiers in Neural Circuits

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

The degradation of the inwardly rectifying potassium channel, Kir2.1, depends on the expression level: Examination with fluorescent proteins

(2013) Masayoshi Okada et al.   BRAIN RESEARCH

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

Functional labeling of neurons and their projections using the synthetic activity–dependent promoter E-SARE

(2013) Takashi Kawashima et al.   NATURE METHODS

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Generation of a Synthetic Memory Trace

(2012) A. R. Garner et al.   SCIENCE

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

The Psychosis High-Risk State

(2012) Paolo Fusar-Poli et al.   JAMA Psychiatry

Single-neuron dynamics in human focal epilepsy

(2011) Wilson Truccolo et al.   NATURE NEUROSCIENCE

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

Factor binding and chromatin modification in the promoter of murine Egr1 gene upon induction

(2010) Gema Tur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Investigating neuronal activity by SPYCODE multi-channel data analyzer

(2010) Luca Leonardo Bologna et al.   NEURAL NETWORKS

Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release

(2009) J. H. Heeroma et al.   Disease Models & Mechanisms

A self-adapting approach for the detection of bursts and network bursts in neuronal cultures

(2009) Valentina Pasquale et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

(2008) T. Kawashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA