Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension

Cell surface fluctuations regulate early embryonic lineage sorting

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Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

(2021) Matteo Amitaba Molè et al.   Cell Reports

Holding it together: when cadherin meets cadherin

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Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions

(2021) Nicoletta I. Petridou et al.   CELL

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Cortical cell stiffness is independent of substrate mechanics

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An adhesion code ensures robust pattern formation during tissue morphogenesis

(2020) Tony Y.-C. Tsai et al.   SCIENCE

Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro

(2020) Gianluca Amadei et al.   DEVELOPMENTAL CELL

Tension heterogeneity directs form and fate to pattern the myocardial wall

(2020) Rashmi Priya et al.   NATURE

Stem-cell-based embryo models for fundamental research and translation

(2020) Jianping Fu et al.   NATURE MATERIALS

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

(2019) Shaopeng Zhang et al.   Nature Communications

Hypo-osmotic-like stress underlies general cellular defects of aneuploidy

(2019) Hung-Ji Tsai et al.   NATURE

Comprehensive Integration of Single-Cell Data

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Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation

(2019) Dong-Yuan Chen et al.   Nature Communications

A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst

(2019) Ritsuya Niwayama et al.   DEVELOPMENTAL CELL

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

(2019) Berna Sozen et al.   DEVELOPMENTAL CELL

Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins

(2019) Jase Gehring et al.   NATURE BIOTECHNOLOGY

Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization

(2018) Sara A Wickström et al.   CURRENT OPINION IN CELL BIOLOGY

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Sorting at embryonic boundaries requires high heterotypic interfacial tension

(2017) Laura Canty et al.   Nature Communications

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Tissue cartography: compressing bio-image data by dimensional reduction

(2015) Idse Heemskerk et al.   NATURE METHODS

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity

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Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

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Role of cell-cell adhesion complexes in embryonic stem cell biology

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In vitro culture of mouse blastocysts beyond the implantation stages

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Covalent and Density-Controlled Surface Immobilization of E-Cadherin for Adhesion Force Spectroscopy

(2014) Dagmar Fichtner et al.   PLoS One

Cadherin-dependent filopodia control preimplantation embryo compaction

(2013) Juan Carlos Fierro-González et al.   NATURE CELL BIOLOGY

Origins and implications of pluripotent stem cell variability and heterogeneity

(2013) Patrick Cahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knowing the Boundaries: Extending the Differential Adhesion Hypothesis in Embryonic Cell Sorting

(2012) J. D. Amack et al.   SCIENCE

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Actin cortex mechanics and cellular morphogenesis

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Computer Simulations of Cell Sorting Due to Differential Adhesion

(2011) Ying Zhang et al.   PLoS One

Cellular Heterogeneity: Do Differences Make a Difference?

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Adherens junctions: from molecules to morphogenesis

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Heterogeneity of Embryonic and Adult Stem Cells

(2008) Thomas Graf et al.   Cell Stem Cell

A 3-D model used to explore how cell adhesion and stiffness affect cell sorting and movement in multicellular systems

(2008) Eirikur Palsson   JOURNAL OF THEORETICAL BIOLOGY

Tensile forces govern germ-layer organization in zebrafish

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