Methylglyoxal – an advanced glycation end products (AGEs) precursor – Inhibits differentiation of human MSC-derived osteoblasts in vitro independently of receptor for AGEs (RAGE)

Experimental Type 2 Diabetes Differently Impacts on the Select Functions of Bone Marrow-Derived Multipotent Stromal Cells

(2021) Jonathan Ribot et al.   Cells

Metastatic Prostate Cancer Cells Secrete Methylglyoxal-Derived MG-H1 to Reprogram Human Osteoblasts into a Dedifferentiated, Malignant-like Phenotype: A Possible Novel Player in Prostate Cancer Bone Metastases

(2021) Cinzia Antognelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics

(2020) Féaron C. Cassidy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular accumulation of advanced glycation end‐products induces osteoblast apoptosis via endoplasmic reticulum stress

(2020) Ryusuke Suzuki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Skin autofluorescence, a non‐invasive biomarker for advanced glycation end‐products, is associated with prevalent vertebral and major osteoporotic fractures: The Rotterdam Study

(2020) Komal Waqas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

(2020) Tanyawan Suantawee et al.   Nutrients

The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study

(2020) Ruoyang Zhai et al.   EXPERIMENTAL CELL RESEARCH

Classically activated mouse macrophages produce methylglyoxal that induces a TLR4‐ and RAGE‐independent proinflammatory response

(2020) Daniel Prantner et al.   JOURNAL OF LEUKOCYTE BIOLOGY

RAGE Signaling in Skeletal Biology

(2019) Lilian I. Plotkin et al.   Current Osteoporosis Reports

Role of Advanced Glycation End-products in Carcinogenesis and their Therapeutic Implications

(2019) David Schröter et al.   CURRENT PHARMACEUTICAL DESIGN

1977-P: Methylglyoxal May Contribute to Bone Loss via Differential Effects on Osteoblast and Osteoclasts

(2019) KEVIN YUE et al.   DIABETES

Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging

(2019) Cecilia Nigro et al.   Cells

Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation

(2019) Rasmus Kold-Christensen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: Role of Nrf2/HO-1 pathway

(2018) Iman O. Sherif   INTERNATIONAL IMMUNOPHARMACOLOGY

The effect of aminoguanidine (AG) and pyridoxamine (PM) on ageing human cortical bone

(2018) O. Abar et al.   Bone & Joint Research

Crocin attenuates methylglyoxal-induced osteoclast dysfunction by regulating glyoxalase, oxidative stress, and mitochondrial function

(2018) Kwang Sik Suh et al.   FOOD AND CHEMICAL TOXICOLOGY

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention

(2017) Sebastian Brings et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advanced glycation end products impair NLRP3 inflammasome–mediated innate immune responses in macrophages

(2017) Seunghwan Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of methylglyoxal to delayed healing of bone injury in diabetes

(2017) Takao Aikawa et al.   Molecular Medicine Reports

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

(2016) N. Rabbani et al.   CLINICAL SCIENCE

Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: Presentation of a dietary AGE database

(2016) Jean L.J.M. Scheijen et al.   FOOD CHEMISTRY

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

(2016) Paulo Matafome et al.   MEDICINAL RESEARCH REVIEWS

Glycative stress from advanced glycation end products (AGEs) and dicarbonyls: An emerging biological factor in cancer onset and progression

(2016) Jer-An Lin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Receptor for Advanced Glycation End Products-Mediated Signaling Impairs the Maintenance of Bone Marrow Mesenchymal Stromal Cells in Diabetic Model Mice

(2016) Eriko Aikawa et al.   STEM CELLS AND DEVELOPMENT

Advanced Glycation End Products, Diabetes, and Bone Strength

(2016) Masahiro Yamamoto et al.   Current Osteoporosis Reports

Suppression of antioxidant Nrf-2 and downstream pathway in H9c2 cells by advanced glycation end products (AGEs) via ERK phosphorylation

(2015) Shun-Yao Ko et al.   BIOCHIMIE

Autophagy Plays a Protective Role in Advanced Glycation End Product-Induced Apoptosis in Cardiomyocytes

(2015) Pengfei Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues

(2015) Huijuan Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

(2015) Andrea M. Brum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary Advanced Glycation End Products and Their Role in Health and Disease

(2015) Jaime Uribarri et al.   Advances in Nutrition

Methylglyoxal, the dark side of glycolysis

(2015) Igor Allaman et al.   Frontiers in Neuroscience

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

(2014) Jing Xue et al.   BIOCHEMISTRY

Mesenchymal stem cells: mechanisms and role in bone regeneration

(2014) Yunhao Qin et al.   POSTGRADUATE MEDICAL JOURNAL

Diabetes, Collagen, and Bone Quality

(2014) Mitsuru Saito et al.   Current Osteoporosis Reports

Bone Collagen: New Clues to Its Mineralization Mechanism from Recessive Osteogenesis Imperfecta

(2013) David R. Eyre et al.   CALCIFIED TISSUE INTERNATIONAL

Methylglyoxal induces oxidative stress and mitochondrial dysfunction in osteoblastic MC3T3-E1 cells

(2013) K. S. Suh et al.   FREE RADICAL RESEARCH

Mesenchymal Stem Cells in Bone Regeneration

(2013) M. Noelle Knight et al.   Advances in Wound Care

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

RAGE in tissue homeostasis, repair and regeneration

(2012) Guglielmo Sorci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet

(2010) Jaime Uribarri et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Non-enzymatic glycation alters microdamage formation in human cancellous bone

(2009) S.Y. Tang et al.   BONE

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

(2009) D. Yao et al.   DIABETES

Hyperglycemic oxoaldehyde, glyoxal, causes barrier dysfunction, cytoskeletal alterations, and inhibition of angiogenesis in vascular endothelial cells: aminoguanidine protection

(2009) Sean M. Sliman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells

(2009) Sybille Franke et al.   ARTHRITIS RESEARCH & THERAPY

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE