Translational Potential of Targeting Anoctamin-1-Encoded Calcium-Activated Chloride Channels in Hypertension
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Translational Potential of Targeting Anoctamin-1-Encoded Calcium-Activated Chloride Channels in Hypertension
Authors
Keywords
-
Journal
BIOCHEMICAL PHARMACOLOGY
Volume -, Issue -, Pages 115320
Publisher
Elsevier BV
Online
2022-10-22
DOI
10.1016/j.bcp.2022.115320
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Downregulation of Ca2+-Activated Cl− Channel TMEM16A Mediated by Angiotensin II in Cirrhotic Portal Hypertensive Mice
- (2022) Rubii Kondo et al. Frontiers in Pharmacology
- Vascular smooth muscle ion channels in essential hypertension
- (2022) Nuria Daghbouche-Rubio et al. Frontiers in Physiology
- A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats
- (2021) Onur Cil et al. KIDNEY INTERNATIONAL
- Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
- (2021) Luca Braga et al. NATURE
- TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner
- (2021) Huaqing Zheng et al. Acta Pharmaceutica Sinica B
- Increased intracellular Cl− concentration in pulmonary arterial myocytes is associated with chronic hypoxic pulmonary hypertension
- (2021) Hui Sun et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Molecular Mechanisms of Activation and Regulation of ANO1-Encoded Ca2+-Activated Cl- Channels
- (2021) M. B. Hawn et al. Channels
- Mucus Release and Airway Constriction by TMEM16A May Worsen Pathology in Inflammatory Lung Disease
- (2021) Raquel Centeio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pulmonary Hypertension in 2021: Part I—Definition, Classification, Pathophysiology, and Presentation
- (2021) Theresa A. Gelzinis JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
- Targeting TMEM16A-encoded Ca2+-activated Cl− channels: a new paradigm for antihypertensive therapy?
- (2021) Normand Leblanc KIDNEY INTERNATIONAL
- Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization
- (2021) Baobin Li et al. Nature Communications
- The Hallmarks of Severe Pulmonary Arterial Hypertension: The Cancer Hypothesis - Ten years later
- (2020) Carlyne D Cool et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis
- (2020) Henry L Danahay et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Current and future treatments of pulmonary arterial hypertension
- (2020) Natascha Sommer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Assessing the cancer hypothesis of pulmonary arterial hypertension: the devil is in the detail
- (2020) Andrea L. Frump et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- The cancer hypothesis of pulmonary arterial hypertension: the next ten years
- (2020) David Condon et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A cancer amidst us: the plexiform lesion in pulmonary arterial hypertension
- (2020) Ji Young Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- The updated cancer paradigm of PAH: recognizing complexity
- (2020) Robert Szulcek et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A
- (2020) Raquel Centeio et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Allosteric modulation of alternatively spliced Ca2+-activated Cl−channels TMEM16A by PI(4,5)P2and CaMKII
- (2020) Woori Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
- (2020) András Varró et al. PHYSIOLOGICAL REVIEWS
- Contribution of Anoctamins to Cell Survival and Cell Death
- (2019) Karl Kunzelmann et al. Cancers
- Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
- (2019) Kent Miner et al. Frontiers in Pharmacology
- TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
- (2019) Karl Kunzelmann et al. Frontiers in Pharmacology
- TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension
- (2019) Henry R. Askew Page et al. BRITISH JOURNAL OF PHARMACOLOGY
- Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic PAH
- (2019) Rita Papp et al. EUROPEAN RESPIRATORY JOURNAL
- Repurposing benzbromarone for pulmonary arterial hypertension: can channelling the past deliver the therapy of the future?
- (2019) Anne L. Theilmann et al. EUROPEAN RESPIRATORY JOURNAL
- Agonism of the TMEM16A Calcium-Activated Chloride Channel Modulates Airway Smooth Muscle Tone
- (2019) Jennifer Danielsson et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels
- (2019) Michele Genovese et al. JOURNAL OF PHYSIOLOGY-LONDON
- Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon
- (2019) Bernard T. Drumm et al. JOURNAL OF PHYSIOLOGY-LONDON
- Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38–Mitogen-activated Protein Kinase–Dependent Apoptosis
- (2018) Ayed M. Allawzi et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Vascular smooth muscle contraction in hypertension
- (2018) Rhian M Touyz et al. CARDIOVASCULAR RESEARCH
- Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl− Channel Regulation in Cerebrovascular Cells
- (2018) Cai-Xia Lin et al. CIRCULATION JOURNAL
- Known structures and unknown mechanisms of TMEM16 scramblases and channels
- (2018) Maria E. Falzone et al. JOURNAL OF GENERAL PHYSIOLOGY
- CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease
- (2018) Thomas J. Jentsch et al. PHYSIOLOGICAL REVIEWS
- CrossTalk proposal: The mouse SuHx model is a good model of pulmonary arterial hypertension
- (2018) Krishna C. Penumatsa et al. JOURNAL OF PHYSIOLOGY-LONDON
- TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase–Derived Reactive Oxygen Species Generation in HypertensionNovelty and Significance
- (2017) Ming-Ming Ma et al. HYPERTENSION
- Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)
- (2017) Eric C. Truong et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
- (2017) Hui Wang et al. Molecular Cancer
- Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
- (2017) Cristina Paulino et al. NATURE
- Cryo-EM structures of the TMEM16A calcium-activated chloride channel
- (2017) Shangyu Dang et al. NATURE
- Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A
- (2017) Cristina Paulino et al. eLife
- Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels
- (2016) Tae Sik Sung et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
- (2016) Yohan Seo et al. PLoS One
- Chloride channels mediate sodium sulphide-induced relaxation in rat uteri
- (2015) Ana Mijušković et al. BRITISH JOURNAL OF PHARMACOLOGY
- The role of Ca2+ activated Cl− channels in blood pressure control
- (2015) Vladimir V Matchkov et al. CURRENT OPINION IN PHARMACOLOGY
- TMEM16A and Myocardin Form a Positive Feedback Loop That Is Disrupted by KLF5 During Ang II–Induced Vascular RemodelingNovelty and Significance
- (2015) Xin-hua Zhang et al. HYPERTENSION
- Targeting ion channels in cystic fibrosis
- (2015) Marcus A. Mall et al. Journal of Cystic Fibrosis
- TMEM16 Proteins: Unknown Structure and Confusing Functions
- (2015) Alessandra Picollo et al. JOURNAL OF MOLECULAR BIOLOGY
- Molecular and Functional Significance of Ca2+-Activated Cl− Channels in Pulmonary Arterial Smooth Muscle
- (2015) Normand Leblanc et al. Pulmonary Circulation
- Progress in solving the sex hormone paradox in pulmonary hypertension
- (2014) Tim Lahm et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Pharmacological characterization of TMEM16A currents
- (2014) Eamonn Bradley et al. Channels
- The Metabolic Theory of Pulmonary Arterial Hypertension
- (2014) Roxane Paulin et al. CIRCULATION RESEARCH
- Symphony of Vascular Contraction
- (2014) Styliani Goulopoulou et al. HYPERTENSION
- Disruption of vascular Ca2+-activated chloride currents lowers blood pressure
- (2014) Christoph Heinze et al. JOURNAL OF CLINICAL INVESTIGATION
- Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein
- (2014) Junya Ohshiro et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- The Ca2+-activated Cl−channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis
- (2014) Zhiqiang Qu et al. Cancer Medicine
- Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats
- (2013) Michie Toba et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The multiple expression of Ca2+-activated Cl− channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein
- (2013) Junya Ohshiro et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cl− channels in smooth muscle cells
- (2013) Simon Bulley et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
- (2013) Adrian Britschgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension
- (2012) Abigail S. Forrest et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- New mechanisms of pulmonary arterial hypertension: role of Ca2+ signaling
- (2012) Frank K. Kuhr et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The Transmembrane Protein 16A Ca2+-activated Cl−Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness
- (2012) Cheng-Hai Zhang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01
- (2012) Alison J Davis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation
- (2012) Mi Wang et al. CIRCULATION
- TMEM16A/ANO1 Channels Contribute to the Myogenic Response in Cerebral Arteries
- (2012) Simon Bulley et al. CIRCULATION RESEARCH
- Update on new aspects of the renin–angiotensin system in liver disease: clinical implications and new therapeutic options
- (2012) Josephine A. Grace et al. CLINICAL SCIENCE
- Ca2+-activated Cl- channels at a glance
- (2012) J. Berg et al. JOURNAL OF CELL SCIENCE
- Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity
- (2012) Hui Sun et al. JOURNAL OF PHYSIOLOGY-LONDON
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
- (2012) F. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TMEM16A channels generate Ca2+-activated Cl− currents in cerebral artery smooth muscle cells
- (2011) Candice Thomas-Gatewood et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A Novel Murine Model of Severe Pulmonary Arterial Hypertension
- (2011) Loredana Ciuclan et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Electrical Slow Waves in the Mouse Oviduct Are Dependent upon a Calcium Activated Chloride Conductance Encoded by Tmem16a1
- (2011) Rose Ellen Dixon et al. BIOLOGY OF REPRODUCTION
- Sex Differences in the Diagnosis, Treatment, and Outcome of Patients With Pulmonary Arterial Hypertension Enrolled in the Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management
- (2011) Shelley Shapiro et al. CHEST
- Anoctamins and gastrointestinal smooth muscle excitability
- (2011) Kenton M. Sanders et al. EXPERIMENTAL PHYSIOLOGY
- Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
- (2011) Wan Namkung et al. FASEB JOURNAL
- Calcium Signaling in Smooth Muscle
- (2011) D. C. Hill-Eubanks et al. Cold Spring Harbor Perspectives in Biology
- Activity of Ca2+-Activated Cl− Channels Contributes to Regulating Receptor- and Store-Operated Ca2+ Entry in Human Pulmonary Artery Smooth Muscle Cells
- (2011) Aya Yamamura et al. Pulmonary Circulation
- Expression profile and protein translation of TMEM16A in murine smooth muscle
- (2010) Alison J. Davis et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The serotonin transporter, gender, and 17 oestradiol in the development of pulmonary arterial hypertension
- (2010) K. White et al. CARDIOVASCULAR RESEARCH
- Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension
- (2010) Kohtaro Abe et al. CIRCULATION
- Basic Science of Pulmonary Arterial Hypertension for Clinicians
- (2010) Stephen L. Archer et al. CIRCULATION
- Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
- (2010) Wan Namkung et al. FASEB JOURNAL
- Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A
- (2010) Yuemin Tian et al. FASEB JOURNAL
- Expression and Function of Epithelial Anoctamins
- (2010) Rainer Schreiber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells
- (2010) Wan Namkung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TMEM16A/Anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells
- (2010) Boris Manoury et al. JOURNAL OF PHYSIOLOGY-LONDON
- The Role of Mitochondria in Apoptosis
- (2009) Chunxin Wang et al. Annual Review of Genetics
- Phosphorylation alters the pharmacology of Ca2+-activated Cl- channels in rabbit pulmonary arterial smooth muscle cells
- (2009) M Wiwchar et al. BRITISH JOURNAL OF PHARMACOLOGY
- Bestrophin and TMEM16—Ca2+ activated Cl− channels with different functions
- (2009) Karl Kunzelmann et al. CELL CALCIUM
- Cardiac Ion Channels
- (2009) Augustus O. Grant Circulation-Arrhythmia and Electrophysiology
- Complex Phosphatase Regulation of Ca2+-activated Cl−Currents in Pulmonary Arterial Smooth Muscle Cells
- (2009) Ramon Ayon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport
- (2009) Jiraporn Ousingsawat et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
- (2009) Sung Jin Hwang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Studies on expression and function of the TMEM16A calcium-activated chloride channel
- (2009) Fen Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit
- (2008) Björn Christian Schroeder et al. CELL
- Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation
- (2008) Anja M. Geerts et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels
- (2008) H. Criss Hartzell et al. JOURNAL OF PHYSIOLOGY-LONDON
- TMEM16A confers receptor-activated calcium-dependent chloride conductance
- (2008) Young Duk Yang et al. NATURE
- Vasomotion has chloride-dependency in rat mesenteric small arteries
- (2008) D. M. Briggs Boedtkjer et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Molecular Physiology of Bestrophins: Multifunctional Membrane Proteins Linked to Best Disease and Other Retinopathies
- (2008) H. Criss Hartzell et al. PHYSIOLOGICAL REVIEWS
- TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
- (2008) A. Caputo et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started