The potent role of Src kinase-regulating glucose metabolism in cancer

Regulatory Roles of the N-Terminal Intrinsically Disordered Region of Modular Src

(2022) Goro Kato   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma

(2022) Xiangyu Wang et al.   CELLULAR ONCOLOGY

An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy

(2022) Mingli Yang et al.   BMC CANCER

Hexokinase 1 cellular localization regulates the metabolic fate of glucose

(2022) Adam De Jesus et al.   MOLECULAR CELL

NEDD9 sustains hexokinase expression to promote glycolysis

(2022) Alexander Y. Deneka et al.   Oncogenesis

Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism

(2022) Abhilasha Sharma et al.   Frontiers in Genetics

How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives

(2022) Luca Simula et al.   Cancers

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

(2022) Mamatha Kakarla et al.   Cancers

Cross-Talk between Wnt Signaling and Src Tyrosine Kinase

(2022) Jung Ki Min et al.   Biomedicines

Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

(2022) Valerie G. Brunton et al.   CANCER RESEARCH

Cancer metabolism control by natural products: Pyruvate kinase M2 targeting therapeutics

(2022) Ali H. El‐Far et al.   PHYTOTHERAPY RESEARCH

Tumor metabolic reprogramming in lung cancer progression (Review)

(2022) Xin Li et al.   Oncology Letters

Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury

(2022) Nannan Li et al.   Biomolecules

Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors

(2022) Salvatore Princiotto et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism

(2022) Wenke Wang et al.   Cell Death Discovery

c-Src facilitates tumorigenesis by phosphorylating and activating G6PD

(2021) Huanhuan Ma et al.   ONCOGENE

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

(2021) Xin Peng et al.   Frontiers in Immunology

The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer

(2021) Claudia Curcio et al.   MOLECULES

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

(2021) Xiaoqing Luo et al.   Cell Death & Disease

The nonreceptor protein tyrosine kinase Src participates in every step of cancer-induced bone pain

(2021) Yaoyuan Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

(2021) Maria A. Ortiz et al.   Cell Communication and Signaling

Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression

(2021) Elmira Roshani Asl et al.   LIFE SCIENCES

Src and Fyn regulation of NMDA receptors in health and disease

(2021) Vishaal Rajani et al.   NEUROPHARMACOLOGY

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3

(2021) Mingming Sun et al.   BIOCHEMICAL PHARMACOLOGY

c-Src Phosphorylates and Inhibits the Function of the CIC Tumor Suppressor Protein

(2020) Severa Bunda et al.   MOLECULAR CANCER RESEARCH

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

(2020) Huanhuan Ma et al.   Cell Reports

Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

(2020) Wook Jin   Cancers

Src family kinases and pulmonary fibrosis: A review

(2020) Hang Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolic alterations in the tumor microenvironment and their role in oncogenesis

(2020) Lihie Eisenberg et al.   CANCER LETTERS

Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis

(2020) Chien-Wei Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells

(2020) Víctor Mayoral-Varo et al.   PLoS One

Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade

(2020) Paola Indovina et al.   Cancers

SRC Kinase in Glioblastoma: News from an Old Acquaintance

(2020) Claudia Cirotti et al.   Cancers

SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis

(2020) Edwige Voisset et al.   Cancers

Src Family Kinases in the Central Nervous System：Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain

(2020) Lingdi Nie et al.   Current Neuropharmacology

Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells

(2020) Sonia Alcalá et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid metabolism and cancer

(2020) Xueli Bian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283

(2020) Sara G. Pelaz et al.   EBioMedicine

S100A10 Accelerates Aerobic Glycolysis and Malignant Growth by Activating mTOR-Signaling Pathway in Gastric Cancer

(2020) Yan Li et al.   Frontiers in Cell and Developmental Biology

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enzymatic and structural characterization of the Naegleria fowleri glucokinase

(2019) Jillian E. Milanes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emerging roles of aerobic glycolysis in breast cancer

(2019) Z. Wu et al.   Clinical & Translational Oncology

The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer

(2019) Netanya Y. Spencer et al.   SEMINARS IN NEPHROLOGY

CircRNAs in cancer metabolism: a review

(2019) Tao Yu et al.   Journal of Hematology & Oncology

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells

(2019) Vinay Sagar et al.   Cell Death & Disease

Connexin43 peptide, TAT-Cx43266–283, selectively targets glioma cells, impairs malignant growth, and enhances survival in mouse models in vivo

(2019) Myriam Jaraíz-Rodríguez et al.   NEURO-ONCOLOGY

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

(2019) Ali F. Abdel-Wahab et al.   PHARMACOLOGICAL RESEARCH

c-Src inhibitor selectively inhibits triple-negative breast cancer overexpressed Vimentin in vitro and in vivo

(2018) Longquan Lou et al.   CANCER SCIENCE

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

Hexokinase 2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin

(2018) Shili Xu et al.   JOURNAL OF NUCLEAR MEDICINE

Expression of PFKFB3 and Ki67 in lung adenocarcinomas and targeting PFKFB3 as a therapeutic strategy

(2018) Xiaoli Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

(2018) Sangwon Byun et al.   Nature Communications

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

(2018) Eric S. Goetzman et al.   Frontiers in Endocrinology

Regulation of pannexin channels in the central nervous system by Src family kinases

(2017) Alexander W. Lohman et al.   NEUROSCIENCE LETTERS

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

(2017) L Jin et al.   ONCOGENE

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

(2017) Jia Zhang et al.   Nature Communications

Akt activation: A potential strategy to ameliorate insulin resistance

(2017) Zhengyi Zhang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration

(2016) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

(2016) Alessia Calgani et al.   MOLECULAR CANCER THERAPEUTICS

HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms

(2016) C-H Chen et al.   ONCOGENE

PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

(2016) Ji Liang et al.   Nature Communications

MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers

(2016) Pannapa Pinweha et al.   Computational and Structural Biotechnology Journal

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

(2015) S. Jain et al.   CANCER RESEARCH

Role of Hexokinase-1 in the survival of HIV-1-infected macrophages

(2015) Satarupa Sen et al.   CELL CYCLE

Pharmacology of Src family kinases and therapeutic implications of their modulators

(2015) Amit Kumar et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Gluconeogenesis combats cancer: opening new doors in cancer biology

(2015) M W Khan et al.   Cell Death & Disease

Regulation of the Warburg Effect in Early-Passage Breast Cancer Cells

(2015) Ian F. Robey et al.   NEOPLASIA

Src signaling pathways in prostate cancer

(2014) Andreas Varkaris et al.   CANCER AND METASTASIS REVIEWS

Control of vascular smooth muscle function by Src-family kinases and reactive oxygen species in health and disease

(2014) Charles E. MacKay et al.   JOURNAL OF PHYSIOLOGY-LONDON

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

The Role of Src in Colon Cancer and Its Therapeutic Implications

(2013) Jiezhong Chen et al.   Clinical Colorectal Cancer

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Src-mediated regulation of E-cadherin and EMT in pancreatic cancer

(2012) Nagaraj et al.   Frontiers in Bioscience-Landmark

PKM2: a new player in the β-catenin game

(2012) Frédéric Canal et al.   Future Oncology

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

Regulation of glycolysis and the Warburg effect by estrogen-related receptors

(2012) Q Cai et al.   ONCOGENE

Dual Inhibition of Src and GSK3 Maintains Mouse Embryonic Stem Cells, Whose Differentiation Is Mechanically Regulated by Src Signaling

(2012) Takeshi Shimizu et al.   STEM CELLS

Src family kinases and paclitaxel sensitivity

(2011) Xiao-Feng Le et al.   CANCER BIOLOGY & THERAPY

Src activates HIF-1α not through direct phosphorylation of HIF-1α-specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway

(2011) Ho-Youl Lee et al.   CARCINOGENESIS

Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors

(2011) Christoffer Tamm et al.   EXPERIMENTAL CELL RESEARCH

Src family kinases in the nervous system

(2011) Xian-Min Yu et al.   FEBS Journal

Current Status of Src Inhibitors in Solid Tumor Malignancies

(2011) L. N. Puls et al.   ONCOLOGIST

Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival

(2010) Qing-Quan Li et al.   CANCER SCIENCE

The Src Family of Protein Tyrosine Kinases: A New and Promising Target for Colorectal Cancer Therapy

(2010) Christopher Lieu et al.   Clinical Colorectal Cancer

Src Inhibitors in Lung Cancer: Current Status and Future Directions

(2010) Sacha I. Rothschild et al.   Clinical Lung Cancer

Is Src a Viable Target for Treating Solid Tumours?

(2010) B. Elsberger et al.   CURRENT CANCER DRUG TARGETS

SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancer

(2009) Fred Saad et al.   CANCER TREATMENT REVIEWS

Expression patterns of Src-family tyrosine kinases during Xenopus laevis development

(2009) Zoltan Ferjentsik et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Neurite Outgrowth is Dependent on the Association of c-Src and Lipid Rafts

(2009) Hui Zhao et al.   NEUROCHEMICAL RESEARCH

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Gluconeogenesis in Primary Hepatocytes by Stromal Cell-derived Factor-1 (SDF-1) through a c-Src/Akt-dependent Signaling Pathway

(2008) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY