New insights into macrophage subsets in atherosclerosis

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

(2022) Marco Orecchioni et al.   SCIENCE

Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7

(2022) Lili Gu et al.   Nature Communications

Single-Cell RNA-Seq Reveals a Crosstalk between Hyaluronan Receptor LYVE-1-Expressing Macrophages and Vascular Smooth Muscle Cells

(2022) Fabienne Burger et al.   Cells

Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis

(2022) Kaori Endo-Umeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression

(2022) Xinbo Zhang et al.   CIRCULATION RESEARCH

miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques

(2021) Milessa Silva Afonso et al.   CIRCULATION RESEARCH

Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages

(2021) Ekaterina P. Demina et al.   Journal of the American Heart Association

Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression

(2021) Martin Schlegel et al.   CIRCULATION RESEARCH

Immune cell profiling in atherosclerosis: role in research and precision medicine

(2021) Dawn M. Fernandez et al.   Nature Reviews Cardiology

Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

(2021) Alexandre Mezentsev et al.   Biomedicines

Trafficking of Mononuclear Phagocytes in Healthy Arteries and Atherosclerosis

(2021) Lukas Tomas et al.   Frontiers in Immunology

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

(2020) Alyssa M. Flores et al.   Nature Nanotechnology

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA

(2020) Chetna Soni et al.   IMMUNITY

Visualization of cardiovascular development, physiology and disease at the single-cell level: Opportunities and future challenges

(2020) Chen Yifan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

(2020) Cheng Gao et al.   Nature Communications

Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability

(2020) Yaw Asare et al.   CIRCULATION RESEARCH

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

(2020) Alma Zernecke et al.   CIRCULATION RESEARCH

Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling

(2020) Wenzheng Xia et al.   Cell Death & Disease

Mitochondrial Dysfunction and DNA Damage in the Context of Pathogenesis of Atherosclerosis

(2020) Taisiia Shemiakova et al.   Biomedicines

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

(2020) Huize Pan et al.   CIRCULATION

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

(2020) Jesse W. Williams et al.   NATURE IMMUNOLOGY

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease

(2020) Farwah Iqbal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hematopoietic Deficiency of the Long Non-Coding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

(2019) Sebastian Cremer et al.   CIRCULATION

Challenges in unsupervised clustering of single-cell RNA-seq data

(2019) Vladimir Yu Kiselev et al.   NATURE REVIEWS GENETICS

Anticytokine Agents

(2019) Paul M Ridker   CIRCULATION RESEARCH

Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing

(2019) Wenduo Gu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

CD14: Biology and role in the pathogenesis of disease

(2019) Zhenghao Wu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Microanatomy Of Advanced Human Atherosclerotic Plaques Through Single-Cell Transcriptomics

(2019) M. Depuydt et al.   ATHEROSCLEROSIS

Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis

(2019) Yanyong Xu et al.   MOLECULAR THERAPY

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Rapamycin-Loaded Leukosomes Reverse Vascular Inflammation

(2019) Christian Boada et al.   CIRCULATION RESEARCH

CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells

(2019) MD Khurshidul Zahid et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

Transcriptional and epigenetic regulation of macrophages in atherosclerosis

(2019) Tatyana Kuznetsova et al.   Nature Reviews Cardiology

Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions

(2019) Sara McArdle et al.   CIRCULATION RESEARCH

A thioredoxin-mimetic peptide exerts potent anti-inflammatory, anti-oxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet

(2018) Fanny Canesi et al.   CARDIOVASCULAR RESEARCH

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome

(2018) Aritz Lopategi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of macrophage immunometabolism in atherosclerosis

(2018) Graeme J. Koelwyn et al.   NATURE IMMUNOLOGY

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

(2018) Cong-Lin Liu et al.   Nature Reviews Cardiology

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Single-cell RNA sequencing for the study of development, physiology and disease

(2018) S. Steven Potter   Nature Reviews Nephrology

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

(2018) Amir Tajbakhsh et al.   PHARMACOLOGY & THERAPEUTICS

Obesity and Insulin Resistance Promote Atherosclerosis through an IFNγ-Regulated Macrophage Protein Network

(2018) Catherine A. Reardon et al.   Cell Reports

Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel 18 F-Folate Radiotracer

(2018) Adrienne Müller et al.   Molecular Imaging

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis

(2018) Kathryn J. Moore et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?

(2018) Carole Brosseau et al.   Frontiers in Immunology

Soluble CD14 acts as a DAMP in human macrophages: origin and involvement in inflammatory cytokine/chemokine production

(2017) Manuella Lévêque et al.   FASEB JOURNAL

CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation

(2017) Dong An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages in vascular inflammation and atherosclerosis

(2017) Clement Cochain et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

DNA Damage and Repair in Vascular Disease

(2016) Anna Uryga et al.   Annual Review of Physiology

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Macrophage Phenotype and Function in Different Stages of Atherosclerosis

(2016) Ira Tabas et al.   CIRCULATION RESEARCH

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis

(2016) Sara McArdle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Characterizing Cathepsin Activity and Macrophage Subtypes in Excised Human Carotid Plaques

(2016) Ihab Abd-Elrahman et al.   STROKE

Development and Function of Arterial and Cardiac Macrophages

(2016) Filip K. Swirski et al.   TRENDS IN IMMUNOLOGY

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL

(2015) Soo-Ho Choi et al.   Autophagy

Design and Analysis of Single-Cell Sequencing Experiments

(2015) Dominic Grün et al.   CELL

Macrophage polarization: the link between inflammation and related diseases

(2015) Samina Bashir et al.   INFLAMMATION RESEARCH

Inflammation and plaque vulnerability

(2015) G. K. Hansson et al.   JOURNAL OF INTERNAL MEDICINE

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

(2015) Florian Buettner et al.   NATURE BIOTECHNOLOGY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

The role of TREM-2 in internalization and intracellular survival of Brucella abortus in murine macrophages

(2015) Pan Wei et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Macrophage phenotypes in atherosclerosis

(2014) Sophie Colin et al.   IMMUNOLOGICAL REVIEWS

TYROBP in Alzheimer’s Disease

(2014) Jing Ma et al.   MOLECULAR NEUROBIOLOGY

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Mitochondrial DNA damage and atherosclerosis

(2014) Emma P.K. Yu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Quantitative single-cell RNA-seq with unique molecular identifiers

(2013) Saiful Islam et al.   NATURE METHODS

Beyond Stem Cells: Self-Renewal of Differentiated Macrophages

(2013) M. H. Sieweke et al.   SCIENCE

MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice

(2013) Takahiro Horie et al.   Journal of the American Heart Association

Thioredoxin-1 Promotes Anti-Inflammatory Macrophages of the M2 Phenotype and Antagonizes Atherosclerosis

(2012) Khadija El Hadri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth muscle cell phenotypic switching in atherosclerosis

(2012) D. Gomez et al.   CARDIOVASCULAR RESEARCH

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

(2012) K. Otero et al.   JOURNAL OF IMMUNOLOGY

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Role of early growth response 1 in arteriogenesis: Impact on vascular cell proliferation and leukocyte recruitment in vivo

(2012) Tibor Ziegelhoeffer et al.   THROMBOSIS AND HAEMOSTASIS

Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β–Expressing Macrophages

(2012) Yuko Furusho et al.   Journal of the American Heart Association

The Adventitia

(2011) Mark W. Majesky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

(2011) Giulia Chinetti-Gbaguidi et al.   CIRCULATION RESEARCH

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq

(2011) S. Islam et al.   GENOME RESEARCH

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

(2011) Katey J. Rayner et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides

(2011) Katey J. Rayner et al.   NATURE

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

CD9 Tetraspanin Interacts with CD36 on the Surface of Macrophages: A Possible Regulatory Influence on Uptake of Oxidized Low Density Lipoprotein

(2011) Wenxin Huang et al.   PLoS One

Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics

(2011) D. M. Suter et al.   SCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: A novel link between interferon-α and atherosclerosis in lupus

(2010) Jia Li et al.   ARTHRITIS AND RHEUMATISM

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

(2010) Pieter Goossens et al.   Cell Metabolism

Deficiency of Antigen-Presenting Cell Invariant Chain Reduces Atherosclerosis in Mice

(2010) Jiusong Sun et al.   CIRCULATION

The regulation of inflammation by galectin-3

(2009) Neil C. Henderson et al.   IMMUNOLOGICAL REVIEWS

Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice

(2008) Brian L. Harry et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

(2008) Andriy O. Samokhin et al.   ATHEROSCLEROSIS

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Deglycosylation of apo B-containing lipoproteins increase their ability to aggregate and to promote intracellular cholesterol accumulationin vitro

(2008) D. V. Aksenov et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Galectin-3 Is an Amplifier of Inflammation in Atherosclerotic Plaque Progression Through Macrophage Activation And Monocyte Chemoattraction

(2007) Marianna Papaspyridonos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY