Metabolic Engineering of Saccharomyces cerevisiae for Heterologous Carnosic Acid Production

Construction and optimization of Saccharomyces cerevisiae for synthesizing forskolin

(2022) Haiyan Ju et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An in vivo genome‐wide shRNA screen identifies BCL6 as a targetable biomarker of paclitaxel resistance in breast cancer

(2021) Mohammad Sultan et al.   Molecular Oncology

A “push-pull-restrain” strategy to improve citronellol production in Saccharomyces cerevisiae

(2021) Guozhen Jiang et al.   METABOLIC ENGINEERING

Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides

(2021) Yusong Shi et al.   METABOLIC ENGINEERING

The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae

(2020) Ljubov Dzanaeva et al.   CELL BIOLOGY INTERNATIONAL

Heterologous production of the epoxycarotenoid violaxanthin in Saccharomyces cerevisiae

(2020) Vicente F. Cataldo et al.   METABOLIC ENGINEERING

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

(2020) Tianyuan Hu et al.   METABOLIC ENGINEERING

Functional Integration of Two CYP450 Genes Involved in Biosynthesis of Tanshinones for Improved Diterpenoid Production by Synthetic Biology

(2020) Yaping Mao et al.   ACS Synthetic Biology

Therapeutic promises of ginkgolide A: A literature-based review

(2020) Chandan Sarkar et al.   BIOMEDICINE & PHARMACOTHERAPY

High-titer production of 13R-manoyl oxide in metabolically engineered Saccharomyces cerevisiae

(2019) Chuanbo Zhang et al.   Microbial Cell Factories

Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae

(2019) Dorival Martins et al.   Scientific Reports

Overexpression of the transcription factor HAC1 improves nerolidol production in engineered yeast

(2019) Zhenzhen Qu et al.   ENZYME AND MICROBIAL TECHNOLOGY

Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway

(2019) Jae-Eung Kim et al.   METABOLIC ENGINEERING

Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants

(2018) Ming Zhu et al.   METABOLIC ENGINEERING

Production of sesquiterpenoid zerumbone from metabolic engineered Saccharomyces cerevisiae

(2018) Chuanbo Zhang et al.   METABOLIC ENGINEERING

Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats

(2018) Juanying Ou et al.   Food & Function

Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity

(2018) Xin-wei Liu et al.   ACTA PHARMACOLOGICA SINICA

Discovery and Engineering of Cytochrome P450s for Terpenoid Biosynthesis

(2018) Han Xiao et al.   TRENDS IN BIOTECHNOLOGY

Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae

(2017) Guo-Zhen Jiang et al.   METABOLIC ENGINEERING

Overcoming the plasticity of plant specialized metabolism for selective diterpene production in yeast

(2017) Codruta Ignea et al.   Scientific Reports

Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production inSaccharomyces cerevisiae

(2016) Fanglong Zhao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Phytochemical Profiling of Flavonoids, Phenolic Acids, Terpenoids, and Volatile Fraction of a Rosemary (Rosmarinus officinalis L.) Extract

(2016) Pedro Mena et al.   MOLECULES

Carnosic acid biosynthesis elucidated by a synthetic biology platform

(2016) Codruta Ignea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast

(2016) Ulschan Scheler et al.   Nature Communications

Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa

(2014) Xiangmei Zhang et al.   Microbial Cell Factories

Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes

(2014) Kathleen Brückner et al.   PHYTOCHEMISTRY

Network Analysis of the MVA and MEP Pathways for Isoprenoid Synthesis

(2013) Eva Vranová et al.   Annual Review of Plant Biology

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Fine Tuning of Spatial Arrangement of Enzymes in a PCNA-Mediated Multienzyme Complex Using a Rigid Poly-L-Proline Linker

(2013) Tomoaki Haga et al.   PLoS One

CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

(2013) J. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of miltiradiene by metabolically engineeredSaccharomyces cerevisiae

(2012) Zhubo Dai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Relevance of Carnosic Acid, Carnosol, and Rosmarinic Acid Concentrations in the in Vitro Antioxidant and Antimicrobial Activities of Rosmarinus officinalis (L.) Methanolic Extracts

(2012) Maria J. Jordán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

(2012) Yongjin J. Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells

(2012) M.V. BARNI et al.   ONCOLOGY REPORTS

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

(2012) J. K. Michener et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Real-time PCR-based determination of gene copy numbers inPichia pastoris

(2010) Sandra Abad et al.   Biotechnology Journal

Dynamic Lipidomic Insights into the Adaptive Responses of Saccharomyces cerevisiae to the Repeated Vacuum Fermentation

(2010) Xiao Zhou et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases

(2010) Pamela J. Weathers et al.   PHYTOCHEMISTRY REVIEWS

A Balancing Act for Taxol Precursor Pathways in E. coli

(2010) T. Liu et al.   SCIENCE

Two Sources of Mitochondrial NADPH in the YeastSaccharomyces cerevisiae

(2009) Hikaru Miyagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

(2009) Wei Gao et al.   ORGANIC LETTERS

Plant NADPH-cytochrome P450 oxidoreductases

(2009) Kenneth Jensen et al.   PHYTOCHEMISTRY

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Engineering of chaperone systems and of the unfolded protein response

(2008) Saeed U. Khan et al.   CYTOTECHNOLOGY

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA