Pig‐to‐human kidney transplantation using brain‐dead donors as recipients: One giant leap, or only one small step for transplantkind?

First clinical‐grade porcine kidney xenotransplant using a human decedent model

(2022) Paige M. Porrett et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Kidney xenotransplantation in a brain‐dead donor: Glass half‐full or half‐empty?

(2022) Leonardo V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CRISPR/Cas Technology in Pig-to-Human Xenotransplantation Research

(2021) Natalia Ryczek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunological selection and monitoring of patients undergoing pig kidney transplantation

(2021) Aaron C.K. Lucander et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy After Kidney Transplantation: An Underdiagnosed and Potentially Reversible Entity

(2021) Ana Ávila et al.   Frontiers in Medicine

Targeting peripheral immune organs with self‐assembling prodrug nanoparticles ameliorates allogeneic heart transplant rejection

(2021) Ke Zhou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques

(2021) David Ma et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig‐to‐baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments

(2021) Lars Burdorf et al.   AMERICAN JOURNAL OF TRANSPLANTATION

“You cannot stay in the laboratory forever”*: Taking pig kidney xenotransplantation from the laboratory to the clinic

(2021) David K.C. Cooper et al.   EBioMedicine

Genetically engineered pig kidney transplantation in a brain‐dead human subject

(2021) David K.C. Cooper   XENOTRANSPLANTATION

Xenotransplantation: Current Status in Preclinical Research

(2020) Tianyu Lu et al.   Frontiers in Immunology

Prevention of infection in xenotransplantation: Designated pathogen‐free swine in the safety equation

(2020) Jay A. Fishman   XENOTRANSPLANTATION

Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout)

(2020) Takayuki Yamamoto et al.   Scientific Reports

Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality

(2019) Geert Meyfroidt et al.   INTENSIVE CARE MEDICINE

Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts is Dependent on CD4 T cell Depletion

(2019) S C Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018

(2019) Wayne J. Hawthorne et al.   XENOTRANSPLANTATION

LIFE-SUPPORTING KIDNEY XENOTRANSPLANTATION FROM GENETICALLY-ENGINEERED PIGS IN BABOONS

(2019) Takayuki Yamamoto et al.   TRANSPLANTATION

Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival

(2019) Hironosuke Watanabe et al.   XENOTRANSPLANTATION

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

(2018) Arne Hinrichs et al.   Molecular Metabolism

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Application of next generation sequencing in clinical microbiology and infection prevention

(2017) Ruud H. Deurenberg et al.   JOURNAL OF BIOTECHNOLOGY

Genome-editing technologies to improve research, reproduction, and production in pigs

(2017) Kevin D. Wells et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs

(2017) Gregory R. Martens et al.   TRANSPLANTATION

Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression

(2017) Jun-Seop Shin et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

Let’s Tie the Knot: Marriage of Complement and Adaptive Immunity in Pathogen Evasion, for Better or Worse

(2017) Kaila M. Bennett et al.   Frontiers in Microbiology

Complement Evasion Strategies of Viruses: An Overview

(2017) Palak Agrawal et al.   Frontiers in Microbiology

The pathobiology of pig-to-primate xenotransplantation: a historical review

(2016) David K.C. Cooper et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

Long-Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine Islets

(2015) J. S. Shin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Management of the Potential Organ Donor in the ICU

(2015) Robert M. Kotloff et al.   CRITICAL CARE MEDICINE

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

T-cell-mediated immunological barriers to xenotransplantation

(2012) Joseph Scalea et al.   XENOTRANSPLANTATION

Activation of hemostasis in brain dead organ donors: an observational study

(2011) T. LISMAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Suboptimal Porcine Endogenous Retrovirus Infection in Non-Human Primate Cells: Implication for Preclinical Xenotransplantation

(2010) Giada Mattiuzzo et al.   PLoS One

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION