Mechanical regulation of chromatin and transcription

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

(2022) Shamik Mascharak et al.   Cell Stem Cell

Transmural pressure signals through retinoic acid to regulate lung branching

(2022) Jacob M. Jaslove et al.   DEVELOPMENT

Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance

(2022) Patrizia Romani et al.   NATURE CELL BIOLOGY

Myosin VI regulates the spatial organisation of mammalian transcription initiation

(2022) Yukti Hari-Gupta et al.   Nature Communications

Programmed and self-organized flow of information during morphogenesis

(2021) Claudio Collinet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biophysics of Notch Signaling

(2021) David Sprinzak et al.   Annual Review of Biophysics

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation

(2021) Dakota L. Jones et al.   JOURNAL OF CELL BIOLOGY

Actin cables and comet tails organize mitochondrial networks in mitosis

(2021) Andrew S. Moore et al.   NATURE

Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer

(2021) Allison P. Drain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities

(2021) Erine H Budi et al.   JOURNAL OF PATHOLOGY

Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring

(2021) Shamik Mascharak et al.   SCIENCE

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

(2021) Emma Carley et al.   eLife

Mechanical homeostasis of liver sinusoid is involved in the initiation and termination of liver regeneration

(2021) Jun Ishikawa et al.   Communications Biology

Vascular Mechanobiology: Homeostasis, Adaptation, and Disease

(2021) Jay D. Humphrey et al.   Annual Review of Biomedical Engineering

Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics

(2021) Nikhil Mishra et al.   Annual Review of Genetics

Adhesion-mediated mechanosignaling forces mitohormesis

(2021) Kevin M. Tharp et al.   Cell Metabolism

Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

(2021) Hyojin Park et al.   CIRCULATION

KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

(2021) Juan Huang et al.   CIRCULATION RESEARCH

Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition

(2021) Christopher J. Price et al.   DEVELOPMENTAL CELL

FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply

(2021) Himanish Basu et al.   JOURNAL OF CELL BIOLOGY

Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19

(2021) Katarzyna Majstrowicz et al.   JOURNAL OF CELL SCIENCE

Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch

(2021) Yekaterina A. Miroshnikova et al.   MOLECULAR BIOLOGY OF THE CELL

CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling

(2021) Shan Wang et al.   NATURE CELL BIOLOGY

Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling

(2021) Hanqiang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Forces in Nuclear Organization

(2021) Yekaterina A. Miroshnikova et al.   Cold Spring Harbor Perspectives in Biology

Disrupting biological sensors of force promotes tissue regeneration in large organisms

(2021) Kellen Chen et al.   Nature Communications

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues

(2021) Nathaniel Kastan et al.   Nature Communications

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

(2021) Arianna Pocaterra et al.   Communications Biology

Combined control of the fibroblast contractile program by YAP and TAZ

(2021) Patrick A. Link et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

(2021) Alberto Elosegui-Artola   CURRENT OPINION IN CELL BIOLOGY

Nuclear pores dilate and constrict in cellulo

(2021) Christian E. Zimmerli et al.   SCIENCE

Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis

(2020) Zengdun Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostaglandin E 2 and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition

(2020) Erika Ishihara et al.   GENES TO CELLS

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

(2020) Miesje van der Stoel et al.   JOURNAL OF CELL SCIENCE

YAP/TAZ functions and their regulation at a glance

(2020) Arianna Pocaterra et al.   JOURNAL OF CELL SCIENCE

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

(2020) Tito Panciera et al.   NATURE MATERIALS

A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma

(2020) Christophe A. Girard et al.   CANCER RESEARCH

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

MASTL promotes cell contractility and motility through kinase-independent signaling

(2020) Maria Emilia Taskinen et al.   JOURNAL OF CELL BIOLOGY

Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface

(2020) Rongbo Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Cortical cell stiffness is independent of substrate mechanics

(2020) Johannes Rheinlaender et al.   NATURE MATERIALS

Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus

(2020) Paulina Nastały et al.   Nature Communications

Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

(2020) Vincenza Caolo et al.   eLife

Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation

(2020) Jian Sun et al.   Science Advances

The Actin-Family Protein Arp4 Is a Novel Suppressor for the Formation and Functions of Nuclear F-Actin

(2020) Shota Yamazaki et al.   Cells

Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation)

(2020) Jin Ye   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions

(2020) Louise A. Moyle et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes

(2020) Laura M. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanisms of stretch-mediated skin expansion at single-cell resolution

(2020) Mariaceleste Aragona et al.   NATURE

Emerging mechanisms of cell competition

(2020) Nicholas E. Baker   NATURE REVIEWS GENETICS

Geometric regulation of histone state directs melanoma reprogramming

(2020) Junmin Lee et al.   Communications Biology

Megadalton chromatin remodelers: common principles for versatile functions

(2020) Anna Jungblut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Establishment of a relationship between blastomere geometry and YAP localisation during compaction

(2020) Christophe Royer et al.   DEVELOPMENT

Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation

(2020) Stefan Biedzinski et al.   EMBO JOURNAL

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

(2020) Jason J. Northey et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytoplasmic control of intranuclear polarity by human cytomegalovirus

(2020) Dean J. Procter et al.   NATURE

The Hippo Pathway in Liver Homeostasis and Pathophysiology

(2020) Jordan H. Driskill et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

(2020) Jonathon M. Muncie et al.   DEVELOPMENTAL CELL

Emerging Properties and Functions of Actin and Actin Filaments Inside the Nucleus

(2020) Svenja Ulferts et al.   Cold Spring Harbor Perspectives in Biology

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

(2020) Paraskevi-Maria Psefteli et al.   Redox Biology

Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate

(2020) Henry De Belly et al.   Cell Stem Cell

Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease

(2019) Elizabeth Min et al.   EXPERIMENTAL CELL RESEARCH

Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency

(2019) Miki Nishio et al.   FASEB JOURNAL

Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

(2019) Zhijun Liu et al.   JOURNAL OF CELL SCIENCE

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

(2019) Rebecca Bertolio et al.   Nature Communications

MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis

(2019) Albertomaria Moro et al.   NATURE CELL BIOLOGY

Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

(2019) Patrizia Romani et al.   NATURE CELL BIOLOGY

F-actin dynamics regulates mammalian organ growth and cell fate maintenance

(2019) Arianna Pocaterra et al.   JOURNAL OF HEPATOLOGY

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

(2019) Tiina Viita et al.   JOURNAL OF CELL SCIENCE

Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity

(2019) Peng Xia et al.   CELL

A role for actomyosin contractility in Notch signaling

(2019) Ginger L. Hunter et al.   BMC BIOLOGY

The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease

(2019) Melanie Maurer et al.   Annual Review of Biomedical Engineering

Tissue Patterning: The Winner Takes It All, the Losers Standing Small

(2019) Sirio Dupont et al.   CURRENT BIOLOGY

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

(2019) Yekaterina A Miroshnikova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth

(2019) Romain Levayer   SEMINARS IN CANCER BIOLOGY

Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa

(2019) Laura De Rosa et al.   Cell Reports

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Actin and Actin-Binding Proteins in DNA Repair

(2019) Verena Hurst et al.   TRENDS IN CELL BIOLOGY

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

(2019) Julien Aureille et al.   EMBO REPORTS

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

(2019) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Materials Stiffness‐Dependent Redox Metabolic Reprogramming of Mesenchymal Stem Cells for Secretome‐Based Therapeutic Angiogenesis

(2019) Haibo Yang et al.   Advanced Healthcare Materials

Identification of Quinolinols as Activators of TEAD-Dependent Transcription

(2019) Ajaybabu V. Pobbati et al.   ACS Chemical Biology

Forced Unfolding of Proteins Directs Biochemical Cascades

(2019) Karanvir Saini et al.   BIOCHEMISTRY

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow

(2019) Dandan Liu et al.   Journal of Translational Medicine

Stiffness Sensing in Cells and Tissues

(2019) Paul A. Janmey et al.   PHYSIOLOGICAL REVIEWS

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice

(2019) Iván M. Moya et al.   SCIENCE

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress

(2019) Nicole C. A. van Engeland et al.   Scientific Reports

Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

(2019) Tung Bui et al.   Cell Reports

Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

(2019) Bailey V. Fearing et al.   FASEB JOURNAL

The Plot Thickens: The Emerging Role of Matrix Viscosity in Cell Mechanotransduction

(2019) Marco Cantini et al.   Advanced Healthcare Materials

Unraveling the Mechanobiology of Extracellular Matrix

(2018) Viola Vogel   Annual Review of Physiology

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

β-Actin–dependent global chromatin organization and gene expression programs control cellular identity

(2018) Xin Xie et al.   FASEB JOURNAL

Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity

(2018) Charlène Gayrard et al.   JOURNAL OF CELL BIOLOGY

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression

(2018) Anne-Clémence Vion et al.   JOURNAL OF CELL BIOLOGY

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms and impact of altered tumour mechanics

(2018) Hamid Mohammadi et al.   NATURE CELL BIOLOGY

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

(2018) Ekrem Emrah Er et al.   NATURE CELL BIOLOGY

Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction

(2018) Jau-Ye Shiu et al.   NATURE CELL BIOLOGY

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

(2018) Olivia M. Yu et al.   ONCOGENE

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

(2018) Stefan Donat et al.   eLife

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

(2018) Jens-Christian Röper et al.   eLife

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

Zebrafish mutants and TEAD reporters reveal essential functions for Yap and Taz in posterior cardinal vein development

(2018) Matteo Astone et al.   Scientific Reports

Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma

(2018) Woojin M. Han et al.   Science Advances

Characterizing Inner Pressure and Stiffness of Trophoblast and Inner Cell Mass of Blastocysts

(2018) Xian Wang et al.   BIOPHYSICAL JOURNAL

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

(2018) Thomas Bertero et al.   Cell Metabolism

The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish

(2018) Chaitanya Dingare et al.   DEVELOPMENT

TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

(2018) Nikolaos Doumpas et al.   EMBO JOURNAL

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

(2018) John M. Lamar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

(2018) Stéphanie Torrino et al.   JOURNAL OF CELL BIOLOGY

The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

(2018) Lei Chang et al.   NATURE

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming

(2018) Xin Xie et al.   PLoS Genetics

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis

(2017) Mireille Khacho et al.   HUMAN MOLECULAR GENETICS

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

(2017) Jongshin Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

(2017) Amnon Buxboim et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

(2017) Irena L. Ivanovska et al.   MOLECULAR BIOLOGY OF THE CELL

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

(2017) Yuka Morikawa et al.   NATURE

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular stretching modulates mechanosensing pathways

(2017) Xian Hu et al.   PROTEIN SCIENCE

Primary cilia: Cell and molecular mechanosensors directing whole tissue function

(2017) Milos Spasic et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NOTCH1 is a mechanosensor in adult arteries

(2017) Julia J. Mack et al.   Nature Communications

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6

(2017) Ana Paula Zen Petisco Fiore et al.   Cell Reports

Mechanical force induces mitochondrial fission

(2017) Sebastian Carsten Johannes Helle et al.   eLife

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

(2017) Chuwen Lin et al.   eLife

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis

(2016) Aaron R. Froese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

(2016) Balázs Enyedi et al.   CELL

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

Yap1 is dispensable for self‐renewal but required for proper differentiation of mouse embryonic stem (ES) cells

(2016) HaeWon Chung et al.   EMBO REPORTS

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

Crim1 regulates integrin signaling in murine lens development

(2016) Ying Zhang et al.   JOURNAL OF CELL SCIENCE

4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation

(2016) Juhyun Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

SRF Co-factors Control the Balance between Cell Proliferation and Contractility

(2016) Francesco Gualdrini et al.   MOLECULAR CELL

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development

(2016) Aleksandar I. Mihajlović et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Keloid progression: a stiffness gap hypothesis

(2016) Chenyu Huang et al.   International Wound Journal

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

YAP Induces Human Naive Pluripotency

(2016) Han Qin et al.   Cell Reports

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations

(2016) Pauline Wales et al.   eLife

EGR1 Regulates Transcription Downstream of Mechanical Signals during Tendon Formation and Healing

(2016) Ludovic Gaut et al.   PLoS One

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization

(2015) Joseph W. O'Connor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells

(2015) Wenfang Tian et al.   JOURNAL OF HEPATOLOGY

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

(2015) Chun-Han Lin et al.   MOLECULAR BIOLOGY OF THE CELL

YAP is essential for tissue tension to ensure vertebrate 3D body shape

(2015) Sean Porazinski et al.   NATURE

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Forcing cells into shape: the mechanics of actomyosin contractility

(2015) Michael Murrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke

(2015) Christine Weinl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin VI regulates gene pairing and transcriptional pause release in T cells

(2015) Cornelia E. Zorca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

(2015) Juliet Rashidian et al.   Science Signaling

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

(2015) Juliet Rashidian et al.   Science Signaling

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis

(2015) Xu Shiwen et al.   PLoS One

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Mechanical Role of Actin Dynamics in the Rheology of the Golgi Complex and in Golgi-Associated Trafficking Events

(2014) David Guet et al.   CURRENT BIOLOGY

Inhibition of RHO–ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst

(2014) Kanako Kono et al.   DEVELOPMENTAL BIOLOGY

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner

(2014) Pengyan Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

(2014) H. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An Absence of Nuclear Lamins in Keratinocytes Leads to Ichthyosis, Defective Epidermal Barrier Function, and Intrusion of Nuclear Membranes and Endoplasmic Reticulum into the Nuclear Chromatin

(2014) H.-J. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2

(2014) Rabea Hinkel et al.   Nature Communications

Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

(2014) Jacky G. Goetz et al.   Cell Reports

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents

(2013) Jessica L. Bell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Bi-Directional Signaling: Extracellular Matrix and Integrin Regulation of Breast Tumor Progression

(2013) Scott Gehler et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells

(2013) A. N. Mardaryev et al.   DEVELOPMENT

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions

(2013) Seiichiro Ishihara et al.   EXPERIMENTAL CELL RESEARCH

Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes

(2013) E. Lund et al.   GENOME RESEARCH

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Signaling between Transforming Growth Factor β (TGF-β) and Transcription Factor SNAI2 Represses Expression of MicroRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis

(2013) Xiangming Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Catenin protects the epidermis from mechanical stresses

(2013) Samriddha Ray et al.   JOURNAL OF CELL BIOLOGY

Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae

(2013) Christine Weinl et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling

(2013) Joseph W. O’Connor et al.   PLoS One

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

(2013) L. S. Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Nuclear Wave1 Is Required for Reprogramming Transcription in Oocytes and for Normal Development

(2013) K. Miyamoto et al.   SCIENCE

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

Collagen VI regulates satellite cell self-renewal and muscle regeneration

(2013) Anna Urciuolo et al.   Nature Communications

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

(2013) Thibaut Brunet et al.   Nature Communications

Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch

(2012) Michele A. Wozniak et al.   CURRENT BIOLOGY

Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin

(2012) Laurence Meloty-Kapella et al.   DEVELOPMENTAL CELL

Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming

(2012) Han Qin et al.   HUMAN MOLECULAR GENETICS

Phosphocaveolin-1 is a mechanotransducer that induces caveola biogenesis via Egr1 transcriptional regulation

(2012) Bharat Joshi et al.   JOURNAL OF CELL BIOLOGY

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

A Novel Network Integrating a miRNA-203/SNAI1 Feedback Loop which Regulates Epithelial to Mesenchymal Transition

(2012) Michèle Moes et al.   PLoS One

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active maintenance of nuclear actin by importin 9 supports transcription

(2012) J. Dopie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical Regulation of Histone Acetylation in Mesenchymal Stem Cells

(2011) Yuan Li et al.   BIOPHYSICAL JOURNAL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes

(2011) K. Miyamoto et al.   GENES & DEVELOPMENT

G-actin Participates in RNA Polymerase II-dependent Transcription Elongation by Recruiting Positive Transcription Elongation Factor b (P-TEFb)

(2011) Tianyang Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts

(2011) Larry L. Luchsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF

(2011) C. Tamm et al.   JOURNAL OF CELL SCIENCE

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

(2011) Chen Luxenburg et al.   NATURE CELL BIOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Tumor suppression by cell competition through regulation of the Hippo pathway

(2011) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

A Pathogenic Relationship Between a Regulator of the Actin Cytoskeleton and Serum Response Factor

(2010) Angela M. Verdoni et al.   GENETICS

Thy-1-Integrin αvβ5Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

(2010) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Depletion of nuclear actin is a key mediator of quiescence in epithelial cells

(2010) V. A. Spencer et al.   JOURNAL OF CELL SCIENCE

Serum response factor is essential for the proper development of skin epithelium

(2010) Angela M. Verdoni et al.   MAMMALIAN GENOME

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

(2009) Tomomi Masumura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice

(2009) Heidi Koegel et al.   JOURNAL OF CLINICAL INVESTIGATION

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1

(2009) Jasimuddin Ahamed et al.   PLoS One

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY