Synthesis of Pleuromutilin

Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates

(2022) Qi Yukki Li et al.   Nature Chemistry

Regio- and Enantioselective Decarboxylative Allylic Benzylation Enabled by Dual Palladium/Photoredox Catalysis

(2022) Changhua Song et al.   ACS Catalysis

Decarboxylation‐Initiated Intermolecular Carbon‐Heteroatom Bond Formation

(2021) Zhongyi Zeng et al.   ADVANCED SYNTHESIS & CATALYSIS

Visible-Light Photoredox-Catalyzed Decarboxylative α-tert-Butylation of C(sp3)–H Bonds of N-Aryltetrahydroisoquinolines with Pivalic Acid under Transition-Metal-Free Conditions

(2021) Jie Liu et al.   SYNLETT

A Platform for Decarboxylative Couplings via Photoredox Catalysis: Direct Access to Carbocations from Carboxylic Acids for Carbon–Oxygen Bond Formation

(2021) Peijun Li et al.   ACS Catalysis

A Concise Enantioselective Approach to Quassinoids

(2021) William P. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-Markovnikov hydro(amino)alkylation of vinylarenes via photoredox catalysis

(2021) Zhao Wu et al.   Nature Communications

A general method for photocatalytic decarboxylative hydroxylation of carboxylic acids

(2020) Shah Nawaz Khan et al.   JOURNAL OF ORGANIC CHEMISTRY

Lefamulin: The First Systemic Pleuromutilin Antibiotic

(2020) Elias B. Chahine et al.   ANNALS OF PHARMACOTHERAPY

Synthesis of Anhydroryanodol

(2020) Kang Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (−)-Daphnezomines A and B

(2020) Guangpeng Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative Halogenation of Organic Compounds

(2020) Andrii Varenikov et al.   CHEMICAL REVIEWS

Roles of Iron Complexes in Catalytic Radical Alkene Cross-Coupling: A Computational and Mechanistic Study

(2019) Dongyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Radical-Polar Crossover Annulation To Access Terpenoid Motifs

(2019) William P. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hindered dialkyl ether synthesis with electrogenerated carbocations

(2019) Jinbao Xiang et al.   NATURE

Late-Stage Functionalization of Arylacetic Acids by Photoredox-Catalyzed Decarboxylative Carbon-Heteroatom Bond Formation

(2018) Yota Sakakibara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Aplysiasecosterol A

(2018) Zhaohong Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (+)-Pleuromutilin

(2018) Elliot P. Farney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial properties and clinical potential of pleuromutilins

(2018) Olivia Goethe et al.   NATURAL PRODUCT REPORTS

Twelve-Step Asymmetric Synthesis of (−)-Nodulisporic Acid C

(2018) Nicole A. Godfrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photo-induced Decarboxylative Heck-Type Coupling of Unactivated Aliphatic Acids and Terminal Alkenes in the Absence of Sacrificial Hydrogen Acceptors

(2018) Hui Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures

(2017) Mingshuo Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe-Catalyzed C–C Bond Construction from Olefins via Radicals

(2017) Julian C. Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A modular and enantioselective synthesis of the pleuromutilin antibiotics

(2017) Stephen K. Murphy et al.   SCIENCE

Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins

(2016) Steven W. M. Crossley et al.   CHEMICAL REVIEWS

Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids Driven by Visible Light and Using Molecular Oxygen

(2016) Hai-Tao Song et al.   JOURNAL OF ORGANIC CHEMISTRY

Ph(i-PrO)SiH2: An Exceptional Reductant for Metal-Catalyzed Hydrogen Atom Transfers

(2016) Carla Obradors et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pleuromutilins: Potent Drugs for Resistant Bugs—Mode of Action and Resistance

(2016) Susanne Paukner et al.   Cold Spring Harbor Perspectives in Medicine

Visible-Light-Induced Decarboxylative Functionalization of Carboxylic Acids and Their Derivatives

(2015) Jun Xuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Concise Approach to Paxilline Indole Diterpenes

(2015) David T. George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Practical and Catalytic Reductive Olefin Coupling

(2014) Julian C. Lo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized olefin cross-coupling to construct carbon–carbon bonds

(2014) Julian C. Lo et al.   NATURE

Synthesis and synthetic chemistry of pleuromutilin

(2014) Neal J. Fazakerley et al.   TETRAHEDRON

Total Synthesis of (+)-Pleuromutilin

(2013) Neal J. Fazakerley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Development of a generic activation mode: nucleophilic α-substitution of ketones via oxy-allyl cations

(2013) Mark N. Vander Wal et al.   Chemical Science

Trimethylaluminum–Triflimide Complexes for the Catalysis of Highly Hindered Diels–Alder Reactions

(2012) Michael E. Jung et al.   ORGANIC LETTERS

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

(2011) Stephen D. Lotesta et al.   Chemical Science

A concise synthesis of the molecular framework of pleuromutilin

(2010) Junjia Liu et al.   CHEMICAL COMMUNICATIONS

A Dialdehyde Cyclization Cascade: An Approach to Pleuromutilin

(2009) Matthew D. Helm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diels−Alder Exo Selectivity in Terminal-Substituted Dienes and Dienophiles: Experimental Discoveries and Computational Explanations

(2009) Yu-hong Lam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Macbecin I

(2008) Justin K. Belardi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

(2003) Susan M. Poulsen et al.   MOLECULAR MICROBIOLOGY