A harmonized atlas of mouse spinal cord cell types and their spatial organization

A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior

(2021) Ryoichi Tashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selecting single cell clustering parameter values using subsampling-based robustness metrics

(2021) Ryan B. Patterson-Cross et al.   BMC BIOINFORMATICS

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

(2021) Jacob A. Blum et al.   NATURE NEUROSCIENCE

A spinoparabrachial circuit defined by Tacr1 expression drives pain

(2021) Arnab Barik et al.   eLife

Computational principles and challenges in single-cell data integration

(2021) Ricard Argelaguet et al.   NATURE BIOTECHNOLOGY

Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets

(2021) Peter J. Osseward et al.   SCIENCE

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

(2021) Mor R. Alkaslasi et al.   Nature Communications

Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons

(2020) Bishakha Mona et al.   GENES & DEVELOPMENT

Neonatal Injury Evokes Persistent Deficits in Dynorphin Inhibitory Circuits within the Adult Mouse Superficial Dorsal Horn

(2020) Chelsie L. Brewer et al.   JOURNAL OF NEUROSCIENCE

Regulation of glutamate receptors by striatal‐enriched tyrosine phosphatase 61 (STEP 61 )

(2020) Sehoon Won et al.   JOURNAL OF PHYSIOLOGY-LONDON

Postnatal maturation of spinal dynorphin circuits and their role in somatosensation

(2020) Chelsie L. Brewer et al.   PAIN

Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq

(2020) Bo Li et al.   NATURE METHODS

Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits

(2020) Erika Polgár et al.   NEUROSCIENCE

Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse

(2020) Andrew M. Bell et al.   Scientific Reports

Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord

(2020) David I Hughes et al.   Neurotherapeutics

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

(2020) Cedric Peirs et al.   NEURON

A Functional Topographic Map for Spinal Sensorimotor Reflexes

(2020) Graziana Gatto et al.   NEURON

Spinal somatostatin-positive interneurons transmit chemical itch

(2019) Mahar Fatima et al.   PAIN

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

(2019) Julien Delile et al.   DEVELOPMENT

Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis

(2019) Silas Maniatis et al.   SCIENCE

Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity

(2019) Myungin Baek et al.   Cell Reports

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity

(2019) Joshua D. Welch et al.   CELL

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function

(2019) Graziana Gatto et al.   CURRENT OPINION IN NEUROBIOLOGY

Cell type and circuit modules in the spinal cord

(2019) Peter J Osseward et al.   CURRENT OPINION IN NEUROBIOLOGY

Joint analysis of heterogeneous single-cell RNA-seq dataset collections

(2019) Nikolas Barkas et al.   NATURE METHODS

Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch

(2019) Haili Pan et al.   NEURON

Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse

(2019) Elizabeth K. Serafin et al.   PAIN

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

(2019) Kieran A. Boyle et al.   Cell Reports

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch

(2019) David Acton et al.   Cell Reports

Supervised classification enables rapid annotation of cell atlases

(2019) Hannah A. Pliner et al.   NATURE METHODS

Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

(2019) Varun Chokshi et al.   NEURON

Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons

(2019) Hugues Petitjean et al.   Cell Reports

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Spinal Circuits for Touch, Pain, and Itch

(2018) Stephanie C. Koch et al.   Annual Review of Physiology

Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus

(2018) Maria Gutierrez-Mecinas et al.   Brain Structure & Function

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Circuit dissection of the role of somatostatin in itch and pain

(2018) Jing Huang et al.   NATURE NEUROSCIENCE

Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

(2018) Marito Hayashi et al.   NEURON

Origin and Segmental Diversity of Spinal Inhibitory Interneurons

(2018) Lora B. Sweeney et al.   NEURON

Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

(2018) Alexander B. Rosenberg et al.   SCIENCE

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn

(2018) Alexander Chamessian et al.   Scientific Reports

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Tal1, Gata2a, and Gata3 Have Distinct Functions in the Development of V2b and Cerebrospinal Fluid-Contacting KA Spinal Neurons

(2018) Livia A. Andrzejczuk et al.   Frontiers in Neuroscience

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

(2018) Yuanyuan Liu et al.   NATURE

Identifying the pathways required for coping behaviours associated with sustained pain

(2018) Tianwen Huang et al.   NATURE

Deep generative modeling for single-cell transcriptomics

(2018) Romain Lopez et al.   NATURE METHODS

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

(2018) Kaya J.E. Matson et al.   Jove-Journal of Visualized Experiments

Delineating the Diversity of Spinal Interneurons in Locomotor Circuits

(2017) Simon Gosgnach et al.   JOURNAL OF NEUROSCIENCE

Identification of spinal circuits involved in touch-evoked dynamic mechanical pain

(2017) Longzhen Cheng et al.   NATURE NEUROSCIENCE

Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles

(2017) Alana I. Mendelsohn et al.   NEURON

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait

(2017) Stephanie C. Koch et al.   NEURON

A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord

(2017) Kieran A. Boyle et al.   NEUROSCIENCE

Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons

(2017) Sébastien Schaller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes

(2017) Lydia Djenoune et al.   Scientific Reports

Bayesian Sparse Regression Analysis Documents the Diversity of Spinal Inhibitory Interneurons

(2016) Mariano I. Gabitto et al.   CELL

Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

(2016) Jay B. Bikoff et al.   CELL

Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion

(2016) Jeffrey Michael Hubbard et al.   CURRENT BIOLOGY

Making sense out of spinal cord somatosensory development

(2016) Helen C. Lai et al.   DEVELOPMENT

Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity

(2016) Barbara A. Sorg et al.   JOURNAL OF NEUROSCIENCE

A quantitative study of neurochemically defined excitatory interneuron populations in laminae I–III of the mouse spinal cord

(2016) Maria Gutierrez-Mecinas et al.   Molecular Pain

Decoding the organization of spinal circuits that control locomotion

(2016) Ole Kiehn   NATURE REVIEWS NEUROSCIENCE

Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position

(2016) Kathryn L. Hilde et al.   NEURON

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

(2016) Lian Cui et al.   NEURON

In Vivo Interrogation of Spinal Mechanosensory Circuits

(2016) Amelia J. Christensen et al.   Cell Reports

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

(2015) Steeve Bourane et al.   CELL

Firing properties of Renshaw cells defined byChrna2are modulated by hyperpolarizing and small conductance ion currentsIhandISK

(2015) Sharn Perry et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetically identified spinal interneurons integrating tactile afferents for motor control

(2015) Tuan V. Bui et al.   JOURNAL OF NEUROPHYSIOLOGY

Dorsal Horn Circuits for Persistent Mechanical Pain

(2015) Cedric Peirs et al.   NEURON

V3 interneuron subpopulations in the mouse spinal cord undergo distinctive postnatal maturation processes

(2015) J. Borowska et al.   NEUROSCIENCE

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

(2015) S. Bourane et al.   SCIENCE

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Presynaptic inhibition of spinal sensory feedback ensures smooth movement

(2014) Andrew J. P. Fink et al.   NATURE

Skilled reaching relies on a V2a propriospinal internal copy circuit

(2014) Eiman Azim et al.   NATURE

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates

(2014) Lydia Djenoune et al.   Frontiers in Neuroanatomy

Dorsally derived spinal interneurons in locomotor circuits

(2013) Anna Vallstedt et al.   Annals of the New York Academy of Sciences

Dual-mode operation of neuronal networks involved in left–right alternation

(2013) Adolfo E. Talpalar et al.   NATURE

Circuits for Grasping: Spinal dI3 Interneurons Mediate Cutaneous Control of Motor Behavior

(2013) Tuan V. Bui et al.   NEURON

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

(2013) Cédric Francius et al.   PLoS One

A Transcription Factor Code Defines Nine Sensory Interneuron Subtypes in the Mechanosensory Area of the Spinal Cord

(2013) Marta Garcia Del Barrio et al.   PLoS One

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn

(2012) D. I. Hughes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Motor Circuits in Action: Specification, Connectivity, and Function

(2012) Silvia Arber   NEURON

Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord

(2011) Bruce Mesnage et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons

(2010) Sandra Rebelo et al.   DEVELOPMENTAL DYNAMICS

SPP1 expression in spinal motor neurons of the macaque monkey

(2010) Tatsuya Yamamoto et al.   NEUROSCIENCE RESEARCH

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

A Cluster of Cholinergic Premotor Interneurons Modulates Mouse Locomotor Activity

(2009) Laskaro Zagoraiou et al.   NEURON

Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

(2009) A. Friese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord

(2008) Clare M. Galtrey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE