Recent advances in biomaterial-boosted adoptive cell therapy

Copper Sulfide Nanoparticle‐Redirected Macrophages for Adoptive Transfer Therapy of Melanoma

(2021) Jiaojiao Xu et al.   ADVANCED FUNCTIONAL MATERIALS

Application of CAR-T Cell Therapy beyond Oncology: Autoimmune Diseases and Viral Infections

(2021) Ekaterina Zmievskaya et al.   Biomedicines

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation

(2021) Claudia Selck et al.   Frontiers in Immunology

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

(2021) Quanyin Hu et al.   Nature Biomedical Engineering

Immunotherapy perspectives in the new era of B-cell editing

(2021) Natsuko Ueda et al.   Blood Advances

Magneto-Activation and Magnetic Resonance Imaging of Natural Killer Cells Labeled with Magnetic Nanocomplexes for the Treatment of Solid Tumors

(2021) Taehoon Sim et al.   ACS Nano

From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer

(2021) Madiha Saeed et al.   ADVANCED MATERIALS

In Vivo Tracking of Cell Viability for Adoptive Natural Killer Cell‐Based Immunotherapy by Ratiometric NIR‐II Fluorescence Imaging

(2021) Naishun Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cryopreservation of NK and T Cells Without DMSO for Adoptive Cell-Based Immunotherapy

(2021) Xue Yao et al.   BIODRUGS

Lipids and Lipid Derivatives for RNA Delivery

(2021) Yuebao Zhang et al.   CHEMICAL REVIEWS

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

(2021) Hongjun Li et al.   National Science Review

Nanoparticle synthesis assisted by machine learning

(2021) Huachen Tao et al.   Nature Reviews Materials

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Cell therapy strategies for COVID-19: Current approaches and potential applications

(2021) Mark M. Zaki et al.   Science Advances

Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

(2021) Edikan A. Ogunnaike et al.   Science Advances

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

(2021) Kewen Lei et al.   Nature Biomedical Engineering

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

(2020) Xucheng Hou et al.   Nature Nanotechnology

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy

(2020) Enrico Fritsche et al.   TRENDS IN BIOTECHNOLOGY

Harnessing the Formation of Natural Killer–Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors

(2020) Sooseok Im et al.   ADVANCED MATERIALS

DNA‐Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy

(2020) Zhuang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Emerging Landscape of Immune Cell Therapies

(2020) Evan W. Weber et al.   CELL

Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells

(2020) Junya Ichikawa et al.   CLINICAL CANCER RESEARCH

A mini-review on rare-earth down-conversion nanoparticles for NIR-II imaging of biological systems

(2020) Yeteng Zhong et al.   Nano Research

Human chimeric antigen receptor macrophages for cancer immunotherapy

(2020) Michael Klichinsky et al.   NATURE BIOTECHNOLOGY

Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

(2020) Maooz Awan et al.   Regenerative Medicine

Nanoparticle‐Mediated Intracellular Protection of Natural Killer Cells Avoids Cryoinjury and Retains Potent Antitumor Functions

(2020) Xue Yao et al.   Advanced Science

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy

(2020) Yu Yang et al.   ACS Nano

Imidazole‐based Synthetic Lipidoids for In Vivo mRNA Delivery into Primary T Lymphocytes

(2020) Xuewei Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CCL21-loaded 3D hydrogels for T cell expansion and differentiation

(2020) Eduardo Pérez del Río et al.   BIOMATERIALS

Macrophages enter CAR immunotherapy

(2020) Madhura Mukhopadhyay   NATURE METHODS

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

(2020) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

T cell responses and therapies against SARS‐CoV‐2 infection

(2020) Salman M. Toor et al.   IMMUNOLOGY

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

(2020) Lauren V. Terry et al.   Frontiers in Immunology

Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy

(2020) Ariel Isser et al.   BIOMATERIALS

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

(2020) Meixi Hao et al.   Science Translational Medicine

Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases

(2020) Anastasiia A. Kalinina et al.   iScience

Gold nanoparticles in biological optical imaging

(2019) Yue Wu et al.   Nano Today

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field

(2019) Laura Sanz-Ortega et al.   JOURNAL OF NANOBIOTECHNOLOGY

A phase II clinical trial of adoptive transfer of haploidentical natural killer cells for consolidation therapy of pediatric acute myeloid leukemia

(2019) Rosa Nguyen et al.   Journal for ImmunoTherapy of Cancer

An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

(2019) Steven Feins et al.   AMERICAN JOURNAL OF HEMATOLOGY

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

(2019) Chu-Xin Li et al.   ADVANCED MATERIALS

Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors

(2019) Weidong Nie et al.   ACS Nano

Engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy

(2019) John W. Hickey et al.   ADVANCED MATERIALS

Aptamer‐Engineered Natural Killer Cells for Cell‐Specific Adaptive Immunotherapy

(2019) Shuanghui Yang et al.   Small

Macroscale biomaterials strategies for local immunomodulation

(2019) Maxence O. Dellacherie et al.   Nature Reviews Materials

Gene editing for immune cell therapies

(2019) Stefanie R. Bailey et al.   NATURE BIOTECHNOLOGY

Biomaterials for Personalized Cell Therapy

(2019) Amanda L. Facklam et al.   ADVANCED MATERIALS

Preservation of cell-based immunotherapies for clinical trials

(2019) RUI LI et al.   CYTOTHERAPY

Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine

(2019) Naho Tateshita et al.   JOURNAL OF CONTROLLED RELEASE

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging

(2019) Adam J. Grippin et al.   ACS Nano

Multifunctional nanoparticles for genetic engineering and bioimaging of natural killer (NK) cell therapeutics

(2019) Kwang-Soo Kim et al.   BIOMATERIALS

CAR T Cells Beyond Cancer: Hope for Immunomodulatory Therapy of Infectious Diseases

(2019) Michelle Seif et al.   Frontiers in Immunology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

(2019) Sarwish Rafiq et al.   Nature Reviews Clinical Oncology

Cancer Immunoimaging with Smart Nanoparticles

(2019) Yu-Chuan Ou et al.   TRENDS IN BIOTECHNOLOGY

Nitinol thin films functionalized with CAR-T cells for the treatment of solid tumours

(2019) Michael E. Coon et al.   Nature Biomedical Engineering

Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells

(2018) Alberto Purwada et al.   BIOMATERIALS

Activation of Human Natural Killer Cells by Graphene Oxide-Templated Antibody Nanoclusters

(2018) Christian Loftus et al.   NANO LETTERS

Separating T Cell Targeting Components onto Magnetically Clustered Nanoparticles Boosts Activation

(2018) Alyssa K. Kosmides et al.   NANO LETTERS

Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity

(2018) Pengxiang Yang et al.   NANO LETTERS

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

(2018) Alexander S Cheung et al.   NATURE BIOTECHNOLOGY

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Designing natural and synthetic immune tissues

(2018) Emily A. Gosselin et al.   NATURE MATERIALS

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

(2018) Haogang Cai et al.   Nature Nanotechnology

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy

(2018) Elizabeth L. Siegler et al.   Cell Stem Cell

Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation

(2018) Judith Guasch et al.   NANO LETTERS

Magnetic delivery of Fe3O4@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment

(2018) Liya Wu et al.   Biomaterials Science

Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery

(2018) Weizhong Zhang et al.   ADVANCED MATERIALS

FDA Approval Summary: Tisagenlecleucel for Treatment of Patients with Relapsed or Refractory B-cell Precursor Acute Lymphoblastic Leukemia

(2018) Maura C. O’Leary et al.   CLINICAL CANCER RESEARCH

FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma

(2018) Najat Bouchkouj et al.   CLINICAL CANCER RESEARCH

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing

(2018) Cory D. Sago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

(2018) Meiying Wu et al.   Nature Communications

Cell‐Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen‐Presenting Cells for T Cell Activation

(2018) Brynn R. Olden et al.   Advanced Healthcare Materials

Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus

(2018) Maria Dall'Era et al.   Arthritis & Rheumatology

A Single-Step Chemoenzymatic Reaction for the Construction of Antibody–Cell Conjugates

(2018) Jie Li et al.   ACS Central Science

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

(2017) Tyrel T. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

(2017) Esther Drent et al.   MOLECULAR THERAPY

Current Perspective on In Vivo Molecular Imaging of Immune Cells

(2017) Anushree Seth et al.   MOLECULES

Biologically Inspired Design of Nanoparticle Artificial Antigen-Presenting Cells for Immunomodulation

(2017) John W. Hickey et al.   NANO LETTERS

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Persistent bacterial infections and persister cells

(2017) Robert A. Fisher et al.   NATURE REVIEWS MICROBIOLOGY

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

(2017) H. F. Moffett et al.   Nature Communications

Visualization of Macrophage Recruitment to Inflammation Lesions using Highly Sensitive and Stable Radionuclide-Embedded Gold Nanoparticles as a Nuclear Bio-Imaging Platform

(2017) Sang Bong Lee et al.   Theranostics

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Immune Complexes Mimicking Synthetic Vaccine Nanoparticles for Enhanced Migration and Cross-Presentation of Dendritic Cells

(2016) Sun-Young Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography

(2016) Peter Chhour et al.   BIOMATERIALS

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Toxicity and management in CAR T-cell therapy

(2016) Challice L Bonifant et al.   Molecular Therapy-Oncolytics

Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy

(2015) Karlo Perica et al.   ACS Nano

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

Nanomedicine for Cancer Immunotherapy: Tracking Cancer-Specific T-Cells in Vivo with Gold Nanoparticles and CT Imaging

(2015) Rinat Meir et al.   ACS Nano

Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy

(2015) Jian Xiang et al.   ACS Nano

Negatively Charged Magnetite Nanoparticle Clusters as Efficient MRI Probes for Dendritic Cell Labeling and In Vivo Tracking

(2015) Changqiang Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Superparamagnetic MRI probes for in vivo tracking of dendritic cell migration with a clinical 3 T scanner

(2015) Ye Xu et al.   BIOMATERIALS

Gold Nanoparticles for In Vitro Diagnostics

(2015) Wen Zhou et al.   CHEMICAL REVIEWS

Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus — A randomized clinical trial

(2015) Gerlies Treiber et al.   CLINICAL IMMUNOLOGY

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

Gold nanoparticles for photoacoustic imaging

(2015) Wanwan Li et al.   Nanomedicine

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

(2015) Ignazio Caruana et al.   NATURE MEDICINE

Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy

(2015) Tari A. King et al.   Nature Reviews Clinical Oncology

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

(2014) Karlo Perica et al.   ACS Nano

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

(2014) Guanying Chen et al.   CHEMICAL REVIEWS

Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma

(2014) T. Chodon et al.   CLINICAL CANCER RESEARCH

Evaluation of intracellular and extracellular trehalose as a cryoprotectant of stem cells obtained from umbilical cord blood

(2014) Juliana Pessanha Rodrigues Motta et al.   CRYOBIOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

A carbon nanotube–polymer composite for T-cell therapy

(2014) Tarek R. Fadel et al.   Nature Nanotechnology

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Therapeutic cell encapsulation: Ten steps towards clinical translation

(2013) Edorta Santos et al.   JOURNAL OF CONTROLLED RELEASE

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Nanoscale Ligand Spacing Influences Receptor Triggering in T Cells and NK Cells

(2013) Derfogail Delcassian et al.   NANO LETTERS

Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays

(2013) Jovana Matic et al.   NANO LETTERS

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging

(2012) Mya S Thu et al.   NATURE MEDICINE

Past, present and future of radiotherapy for the benefit of patients

(2012) Juliette Thariat et al.   Nature Reviews Clinical Oncology

Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen-Specific T Cell Stimulation

(2012) Tarek R. Fadel et al.   Small

CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe

(2012) David E. Gilham et al.   TRENDS IN MOLECULAR MEDICINE

Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy

(2011) Jin Xie et al.   ACCOUNTS OF CHEMICAL RESEARCH

Viral pneumonia

(2011) Olli Ruuskanen et al.   LANCET

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Noninvasive cell-tracking methods

(2011) Moritz F. Kircher et al.   Nature Reviews Clinical Oncology

Overview of a HLA-Ig based “Lego-like system” for T cell monitoring, modulation and expansion

(2010) Mathias Oelke et al.   IMMUNOLOGIC RESEARCH

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Bacterial manipulation of innate immunity to promote infection

(2010) Lautaro Diacovich et al.   NATURE REVIEWS MICROBIOLOGY

Small Upconverting Fluorescent Nanoparticles for Biomedical Applications

(2010) Dev K. Chatterjee et al.   Small

Self-antigen–specific CD8+T cell precursor frequency determines the quality of the antitumor immune response

(2009) Gabrielle A. Rizzuto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy

(2009) Daniel Hollyman et al.   JOURNAL OF IMMUNOTHERAPY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

A Comprehensive Platform for Ex Vivo T-cell Expansion Based on Biodegradable Polymeric Artificial Antigen-presenting Cells

(2008) Erin R Steenblock et al.   MOLECULAR THERAPY

Enhanced Cellular Activation with Single Walled Carbon Nanotube Bundles Presenting Antibody Stimuli

(2008) Tarek R. Fadel et al.   NANO LETTERS