Metal-catalyzed asymmetric heteroarylation of alkenes: diverse activation mechanisms

Concerted vs Nonconcerted Metalation–Deprotonation in Orthogonal Direct C–H Arylation of Heterocycles with Halides: A Computational Study

(2021) Vincent Gandon et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective C2-Allylation of Benzimidazoles Using 1,3-Diene Pronucleophiles

(2021) James Levi Knippel et al.   ORGANIC LETTERS

Nickel-Catalyzed Regio- and Enantioselective Hydroarylation of 1,3-Dienes with Indoles

(2021) Lei Cheng et al.   CCS Chemistry

Construction of All-Carbon Quaternary Stereocenters by Scandium-Catalyzed Intramolecular C–H Alkylation of Imidazoles with 1,1-Disubstituted Alkenes

(2020) Shao-Jie Lou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions

(2020) Noam I. Saper et al.   Nature Chemistry

CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition

(2020) Richard Y. Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Current pharmacological treatments for COVID‐19: What's next?

(2020) Cristina Scavone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cobalt/Lewis Acid Catalysis for Hydrocarbofunctionalization of Alkynes via Cooperative C–H Activation

(2020) Chang-Sheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Functionalizations of C–H Bonds by Chiral Iridium Complexes

(2020) Łukasz Woźniak et al.   CHEMICAL REVIEWS

Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis

(2020) Torben Rogge et al.   ACS Catalysis

Enantioselective Three‐Component Coupling of Heteroarenes, Cycloalkenes and Propargylic Acetates

(2020) Shenghan Teng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Directed, Palladium(II)-Catalyzed Enantioselective anti-Carboboration of Alkenyl Carbonyl Compounds

(2019) Zhen Liu et al.   ACS Catalysis

Regio- and Enantioselective C–H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis

(2019) Wu-Bin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence

(2019) Yuxuan Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals

(2019) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bulky Chiral N-Heterocyclic Carbene Nickel Catalyst Enables Enantioselective C-H Functionalizations of Indoles and Pyrroles

(2019) Johannes Diesel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel/NHC-Catalyzed Asymmetric C-H Alkylation of Fluoroarenes with Alkenes: Synthesis of Enantioenriched Fluorotetralins

(2019) Yuan Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydroalkynylation of Enamides Using Iridium or Rhodium Complexes: DFT Study on the Mechanism and Regioselectivity

(2019) Zhaoyuan Yu et al.   ORGANOMETALLICS

Palladium-Catalyzed Amide-Directed Enantioselective Carboboration of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

(2019) Zibo Bai et al.   ACS Catalysis

Oligothiophene Synthesis by a General C–H Activation Mechanism: Electrophilic Concerted Metalation–Deprotonation (eCMD)

(2019) Long Wang et al.   ACS Catalysis

Asymmetric Wacker-Type Oxyallenylation and Azaallenylation of Cyclic Alkenes

(2019) Shenghan Teng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Base‐Assisted C−H Bond Cleavage in Cross‐Coupling: Recent Insights into Mechanism, Speciation, and Cooperativity

(2019) Brad P. Carrow et al.   ISRAEL JOURNAL OF CHEMISTRY

Construction of Quaternary Stereocenters by Palladium-Catalyzed Carbopalladation-Initiated Cascade Reactions

(2018) Yuanyuan Ping et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Ni–Al Bimetallic Catalyzed exo-Selective C–H Cyclization of Imidazoles with Alkenes

(2018) Yin-Xia Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Carbo- and Aminoboration of Alkenyl Carbonyl Compounds via Five- and Six-Membered Palladacycles

(2018) Zhen Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile

(2018) Michael W. Gribble et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

(2018) Hao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition

(2018) Simon Grélaud et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation

(2018) Xuekai Zhang et al.   Nature Chemistry

Broad-Scope Rh-Catalyzed Inverse-Sonogashira Reaction Directed by Weakly Coordinating Groups

(2018) Eric Tan et al.   ACS Catalysis

Mechanism, selectivity, and reactivity of iridium- and rhodium-catalyzed intermolecular ketone α-alkylation with unactivated olefins via an enamide directing strategy

(2018) Xiaojie Li et al.   Catalysis Science & Technology

Beyond Friedel and Crafts: Innate Alkylation of C-H Bonds in Arenes

(2018) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Friedel and Crafts: Directed Alkylation of C-H Bonds in Arenes

(2018) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Aluminum-Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold

(2018) Joachim Loup et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

Computational Approach to Molecular Catalysis by 3d Transition Metals: Challenges and Opportunities

(2018) Konstantinos D. Vogiatzis et al.   CHEMICAL REVIEWS

Organometal-catalyzed asymmetric Friedel-Crafts reactions

(2018) Majid M. Heravi et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Recent Advances on Mechanistic Studies on C–H Activation Catalyzed by Base Metals

(2018) Daniel Gallego et al.   Open Chemistry

Highly Enantioselective Synthesis of Propargyl Amides through Rh-Catalyzed Asymmetric Hydroalkynylation of Enamides: Scope, Mechanism, and Origin of Selectivity

(2017) Xiao-Yan Bai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Pincer Carbodicarbene Ligands for Enantioselective Rhodium-Catalyzed Hydroarylation of Terminal and Internal 1,3-Dienes with Indoles

(2017) Justin S. Marcum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Branched-Selective Intermolecular Ketone α-Alkylation with Unactivated Alkenes via an Enamide Directing Strategy

(2017) Dong Xing et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aromatic C–H σ-Bond Activation by Ni0, Pd0, and Pt0 Alkene Complexes: Concerted Oxidative Addition to Metal vs Ligand-to-Ligand H Transfer Mechanism

(2017) Shuwei Tang et al.   ORGANOMETALLICS

New Mechanistic Insights on the Selectivity of Transition-Metal-Catalyzed Organic Reactions: The Role of Computational Chemistry

(2016) Xinhao Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Iridium-Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides

(2016) Xiao-Yan Bai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Alkylation of N-Sulfonylbenzamides with Vinyl Ethers via C–H Bond Activation Catalyzed by Hydroxoiridium/Chiral Diene Complexes

(2016) Miyuki Hatano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β,γ-Vicinal Dicarbofunctionalization of Alkenyl Carbonyl Compounds via Directed Nucleopalladation

(2016) Zhen Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis

(2016) Shogo Okumura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Origins of Ligand-Controlled Linear Versus Branched Selectivity of Iridium-Catalyzed Hydroarylation of Alkenes

(2016) Genping Huang et al.   ACS Catalysis

Half-Sandwich Rare-Earth-Catalyzed Olefin Polymerization, Carbometalation, and Hydroarylation

(2015) Masayoshi Nishiura et al.   ACCOUNTS OF CHEMICAL RESEARCH

Domino Carbopalladation/CH Functionalization Sequence: An Expedient Synthesis of Bis-Heteroaryls through Transient Alkyl/Vinyl-Palladium Species Capture

(2015) Upendra K. Sharma et al.   CHEMISTRY-A EUROPEAN JOURNAL

C–H Activation/Functionalization Catalyzed by Simple, Well-Defined Low-Valent Cobalt Complexes

(2015) Brendan J. Fallon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Enantioselective Domino Heck/Intermolecular C–H Bond Functionalization: Development and Application to the Synthesis of (+)-Esermethole

(2015) Wangqing Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters

(2015) Chun Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-Markovnikov Hydroheteroarylation of Unactivated Alkenes with Indoles, Pyrroles, Benzofurans, and Furans Catalyzed by a Nickel–N-Heterocyclic Carbene System

(2015) York Schramm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(I)–Bisphosphine-Catalyzed Asymmetric, Intermolecular Hydroheteroarylation of α-Substituted Acrylate Derivatives

(2014) Claire M. Filloux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C–H Bond Addition of Pyridines to Alkenes Catalyzed by Chiral Half-Sandwich Rare-Earth Complexes

(2014) Guoyong Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Linear-Selective Hydroarylation of Unactivated Terminal and Internal Olefins with Trifluoromethyl-Substituted Arenes

(2014) Joseph S. Bair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Enantioselective construction of remote quaternary stereocentres

(2014) Tian-Sheng Mei et al.   NATURE

Cobalt-Catalyzed Enantioselective Directed C–H Alkylation of Indole with Styrenes

(2014) Pin-Sheng Lee et al.   ORGANIC LETTERS

Regioselective ketone  -alkylation with simple olefins via dual activation

(2014) F. Mo et al.   SCIENCE

Iridium-Catalyzed Intermolecular Asymmetric Hydroheteroarylation of Bicycloalkenes

(2013) Christo S. Sevov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantio- and Regioselective CuH-Catalyzed Hydroamination of Alkenes

(2013) Shaolin Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Synthesis of β-Alkylated α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)–H Bonds with Primary Alkyl Halides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Versatile Rhodium(I) Catalyst System for the Addition of Heteroarenes to both Alkenes and Alkynes by a CH Bond Activation

(2012) Jaeyune Ryu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Insights into Enantioselective Gold-Catalyzed Allylation of Indoles with Alcohols: The Counterion Effect

(2012) Marco Bandini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Intermolecular Hydroamination of Unactivated Aliphatic Alkenes with Amides and Sulfonamides

(2012) Christo S. Sevov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Intermolecular C-Alkylation of 1,2-Diketones with Simple Olefins: A Recyclable Directing Group Strategy

(2012) Zhiqian Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition-State Metal Aryl Bond Stability Determines Regioselectivity in Palladium Acetate Mediated C–H Bond Activation of Heteroarenes

(2012) Alban Petit et al.   ORGANIC LETTERS

Mechanistic Investigation on Scandium-Catalyzed C–H Addition of Pyridines to Olefins

(2012) Gen Luo et al.   ORGANOMETALLICS

Rhodium Catalyzed Chelation-Assisted C–H Bond Functionalization Reactions

(2011) Denise A. Colby et al.   ACCOUNTS OF CHEMICAL RESEARCH

Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms

(2011) Mar Gómez-Gallego et al.   CHEMICAL REVIEWS

Hydrofluoroarylation of Alkynes with Ni Catalysts. C–H Activation via Ligand-to-Ligand Hydrogen Transfer, an Alternative to Oxidative Addition

(2011) Julie Guihaumé et al.   ORGANOMETALLICS

C—H Bond Activation in Transition Metal Species from a Computational Perspective

(2010) David Balcells et al.   CHEMICAL REVIEWS

Overview of the Mechanistic Work on the Concerted Metallation–Deprotonation Pathway

(2010) David Lapointe et al.   CHEMISTRY LETTERS

Phantasmidine: An Epibatidine Congener from the Ecuadorian Poison FrogEpipedobates anthonyi⊥

(2010) Richard W. Fitch et al.   JOURNAL OF NATURAL PRODUCTS

C−H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Imidazoles via Regioselective Sequential Arylation of All Three C−H Bonds and RegioselectiveN-Alkylation Enabled by SEM-Group Transposition

(2010) Jung Min Joo et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Regio- and Enantioselective Copper-Catalyzed Hydroboration of Styrenes

(2009) Dongwan Noh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Gold-Catalyzed Allylic Alkylation of Indoles with Alcohols: An Efficient Route to Functionalized Tetrahydrocarbazoles

(2009) Marco Bandini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium catalyzed enantioselective cyclization of substituted imidazoles via C–H bond activation

(2009) Andy S. Tsai et al.   CHEMICAL COMMUNICATIONS

Mechanisms of C–H bond activation: rich synergy between computation and experiment

(2009) Youcef Boutadla et al.   DALTON TRANSACTIONS

Domino Palladium-Catalyzed Heck-Intermolecular Direct Arylation Reactions

(2009) Olivier René et al.   ORGANIC LETTERS

A Highly Strained Planar-Chiral Platinacycle for Catalytic Activation of Internal Olefins in the Friedel-Crafts Alkylation of Indoles

(2008) Haoxi Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Friedel−Crafts Alkylation ReactionsCopper Showed the Way

(2008) Thomas B. Poulsen et al.   CHEMICAL REVIEWS

Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates

(2008) Serge I. Gorelsky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY