Peptide probes for proteases – innovations and applications for monitoring proteolytic activity

Integration of fluorescent polydopamine nanoparticles on protamine for simple and sensitive trypsin assay

(2021) Fenglan Li et al.   ANALYTICA CHIMICA ACTA

DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells

(2021) Benjamin Brennecke et al.   BIOCONJUGATE CHEMISTRY

Performance of a novel protease-activated fluorescent imaging system for intraoperative detection of residual breast cancer during breast conserving surgery

(2021) Conor R. Lanahan et al.   BREAST CANCER RESEARCH AND TREATMENT

Peptide-based electrochemical biosensors utilized for protein detection

(2021) Veronika Vanova et al.   BIOSENSORS & BIOELECTRONICS

Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay

(2021) Hani A. Alhadrami et al.   Microchimica Acta

Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis

(2021) Brett M. Babin et al.   ACS Central Science

Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases

(2021) Jamie I. Scott et al.   ACS Chemical Biology

An anionic tetraphenyl ethylene based simple and rapid fluorescent probe for detection of trypsin and paraoxon methyl

(2021) Jasvir Kaur et al.   JOURNAL OF MOLECULAR LIQUIDS

A novel peptide-based electrochemical biosensor for the determination of a metastasis-linked protease in pancreatic cancer cells

(2020) Cristina Muñoz-San Martín et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Amplified Electrochemical Biosensing of Thrombin Activity by RAFT Polymerization

(2020) Qiong Hu et al.   ANALYTICAL CHEMISTRY

Activatable Polymeric Reporter For Near-infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer

(2020) Kanyi Pu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Feasibility Study of a Novel Protease-Activated Fluorescent Imaging System for Real-Time, Intraoperative Detection of Residual Breast Cancer in Breast Conserving Surgery

(2020) Barbara L. Smith et al.   ANNALS OF SURGICAL ONCOLOGY

Detection of early adenocarcinoma of the esophagogastric junction by spraying an enzyme-activatable fluorescent probe targeting Dipeptidyl peptidase-IV

(2020) Keiko Yamamoto et al.   BMC CANCER

A Protease-Activated Fluorescent Probe Allows Rapid Visualization of Keratinocyte Carcinoma During Excision

(2020) Ethan Walker et al.   CANCER RESEARCH

Collagen-Immobilized Extracellular FRET Reporter for Visualizing Protease Activity Secreted by Living Cells

(2020) Hawon Lee et al.   ACS Sensors

Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots

(2020) Shi-Yu Liu et al.   ACS Nano

Fluoro‐Photoacoustic Polymeric Renal Reporter for Real‐Time Dual Imaging of Acute Kidney Injury

(2020) Penghui Cheng et al.   ADVANCED MATERIALS

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

(2020) Tomasz Janiszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy

(2020) Shasha He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

(2020) Jesse D. Kirkpatrick et al.   Science Translational Medicine

Monitoring Proteolytic Activity in Real Time: A New World of Opportunities for Biosensors

(2020) Rui Oliveira-Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activity-based ratiometric fluorescent small-molecule probe for endogenously monitoring neutrophil elastase in living cells

(2020) Ting Cao et al.   ANALYTICA CHIMICA ACTA

Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts

(2020) Martina Tholen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and characterisation of a compact device for rapid real-time-on-chip detection of thrombin activity in human serum using bioluminescence resonance energy transfer (BRET)

(2020) Felix Weihs et al.   BIOSENSORS & BIOELECTRONICS

Acoustic biosensors for ultrasound imaging of enzyme activity

(2020) Anupama Lakshmanan et al.   Nature Chemical Biology

γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging

(2020) Rui Obara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coumarin as a structural component of substrates and probes for serine and cysteine proteases

(2020) Julian Breidenbach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Powerful Chemiluminescence Probe for Rapid Detection of Prostate Specific Antigen Proteolytic Activity: Forensic Identification of Human Semen

(2020) Sara Gutkin et al.   BIOCONJUGATE CHEMISTRY

AND-gate contrast agents for enhanced fluorescence-guided surgery

(2020) John C. Widen et al.   Nature Biomedical Engineering

A Functional Chemiluminescent Probe for in vivo Imaging of Natural Killer Cell Activity against Tumours

(2020) Jamie Scott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Swarming: In Situ Generation of Dendrimers

(2020) Yichuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A protease-activated, near-infrared fluorescent probe for early endoscopic detection of premalignant gastrointestinal lesions

(2020) Joshua J. Yim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of a dendrimer with a matrix metalloproteinase-responsive fluorescence probe and a tumor-homing peptide for metastatic tumor cell imaging in the lymph node

(2020) Kento Nagai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A ratiometric fluorescent probe based on quinoline for monitoring and imaging of Leucine aminopeptidase in liver tumor cells

(2020) Kui Du et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase

(2019) Shi-Yu Liu et al.   ANALYTICAL CHEMISTRY

Transducing Protease Activity into DNA Output for Developing Smart Bionanosensors

(2019) Hieu Bui et al.   Small

Trends in the Design of New Isobaric Labeling Reagents for Quantitative Proteomics

(2019) Remigiusz Bąchor et al.   MOLECULES

A Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging

(2019) Hao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitatively Visualizing Tumor-Related Protease Activity in Vivo Using a Ratiometric Photoacoustic Probe

(2019) Ling Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A brief review of bioluminescent systems (2019)

(2019) Aubin Fleiss et al.   CURRENT GENETICS

A Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

(2019) Akira Ogasawara et al.   BIOCONJUGATE CHEMISTRY

Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe

(2019) Mylène Wartenberg et al.   BIOCHIMIE

A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly

(2019) Yuqi Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrochemical Activity Assay for Protease Analysis Using Carbon Nanofiber Nanoelectrode Arrays

(2019) Yang Song et al.   ANALYTICAL CHEMISTRY

Matrix metallopeptidase 2 targeted delivery of gold nanostars decorated with IR-780 iodide for dual-modal imaging and enhanced photothermal/photodynamic therapy

(2019) Fangfang Xia et al.   Acta Biomaterialia

Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity

(2019) Quoc D. Mac et al.   Nature Biomedical Engineering

Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo

(2019) Ling Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine

(2019) Hui Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A signal-on electrochemical biosensor for evaluation of caspase-3 activity and cell apoptosis by the generation of molecular electrocatalysts on graphene electrode surface for water oxidation

(2019) Dehua Deng et al.   SENSORS AND ACTUATORS B-CHEMICAL

Fluorogenic Probe for Detecting Active Matrix Metalloproteinase-3 (MMP-3) in Plasma and Peripheral Blood Neutrophils to Indicate the Severity of Rheumatoid Arthritis

(2019) Ruda Lee et al.   ACS Biomaterials-Science & Engineering

Recent Advances and Challenges in Luminescent Imaging: Bright Outlook for Chemiluminescence of Dioxetanes in Water

(2019) Nir Hananya et al.   ACS Central Science

Nanocellulose as a colorimetric biosensor for effective and facile detection of human neutrophil elastase

(2019) Zhe Ling et al.   CARBOHYDRATE POLYMERS

Persistent Chemiluminescent Glow of Phenoxy‐Dioxetane Luminophore Enables Unique CRET‐Based Detection of Proteases

(2019) Doron Shabat et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo

(2019) Sarah Talley et al.   JOURNAL OF IMMUNOLOGY

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

(2019) Colleen N. Loynachan et al.   Nature Nanotechnology

Cathepsin B Turning Bioluminescence “On” for Tumor Imaging

(2019) Yanhan Ni et al.   ANALYTICAL CHEMISTRY

Protease Activity in Vascular Disease

(2019) Megan A. Slack et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Highly sensitive fluorescence imaging of cancer with avidin-protease probe conjugate

(2019) Kyoko Yamamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity

(2019) Shusheng Wang et al.   BIOORGANIC CHEMISTRY

A red-shifted Bioluminescence Resonance Energy Transfer (BRET) biosensing system for rapid measurement of plasmin activity in human plasma

(2019) Felix Weihs et al.   ANALYTICA CHIMICA ACTA

Precisely Tuning LSPR Property via “Peptide-Encoded” Morphological Evolution of Gold Nanorods for Quantitative Visualization of Enzyme Activity

(2019) Meng-Qi He et al.   ANALYTICAL CHEMISTRY

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis Ex Vivo

(2019) Sunil Mathur et al.   International Journal of Peptide Research and Therapeutics

Bioorthogonal “Labeling after Recognition” Affording an FRET-Based Luminescent Probe for Detecting and Imaging Caspase-3 via Photoluminescence Lifetime Imaging

(2019) Qi Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A rapid and sensitive biosensor for measuring plasmin activity in milk

(2019) Helen Dacres et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rapid Colorimetric Detection of Pseudomonas aeruginosa in Clinical Isolates Using a Magnetic Nanoparticle Biosensor

(2019) Sahar Alhogail et al.   ACS Omega

A turn-on fluorescence probe based on aggregation-induced emission for leucine aminopeptidase in living cells and tumor tissue

(2018) Shuailing Huang et al.   ANALYTICA CHIMICA ACTA

Activatable Near-Infrared Fluorescent Probe for Dipeptidyl Peptidase IV and Its Bioimaging Applications in Living Cells and Animals

(2018) Tao Liu et al.   ANALYTICAL CHEMISTRY

Peptides for optical medical imaging and steps towards therapy

(2018) Matteo Staderini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity walls using a novel cathepsin-activated fluorescent imaging system

(2018) Barbara L. Smith et al.   BREAST CANCER RESEARCH AND TREATMENT

A novel three-fluorophore system as a ratiometric sensor for multiple protease detection

(2018) Yana Okorochenkova et al.   CHEMICAL COMMUNICATIONS

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

(2018) Xiaolin Huang et al.   CHEMICAL SOCIETY REVIEWS

Near-infrared fluorescent probes for peptidases

(2018) Jik Chin et al.   COORDINATION CHEMISTRY REVIEWS

Rapid detection of superficial head and neck squamous cell carcinoma by topically spraying fluorescent probe targeting dipeptidyl peptidase-IV

(2018) Takeshi Mizushima et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Gold nanoparticle-based colorimetric method for the detection of prostate-specific antigen

(2018) Ning Xia et al.   International Journal of Nanomedicine

Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe

(2018) Cheng Liu et al.   MOLECULAR IMAGING AND BIOLOGY

Gold nanoparticle-based colorimetric biosensors

(2018) H. Aldewachi et al.   Nanoscale

A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide

(2018) Lin Liu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Histone controlled aggregation of tetraphenylethene probe: A new method for the detection of protease activity

(2018) Yunyi Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Kinetics improvement of protease-mediated formation of pyronin dyes

(2018) Sylvain Debieu et al.   TETRAHEDRON LETTERS

Peptide cleavage-based electrochemical biosensor coupling graphene oxide and silver nanoparticles

(2018) Fanyu Meng et al.   ANALYTICA CHIMICA ACTA

Electrochemical sensing of human neutrophil elastase and polymorphonuclear neutrophil activity

(2018) Eva González-Fernández et al.   BIOSENSORS & BIOELECTRONICS

Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer

(2018) Alicia Megia-Fernandez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Classification of prostate cancer using a protease activity nanosensor library

(2018) Jaideep S. Dudani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils

(2018) Thomas H. Craven et al.   Scientific Reports

Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in Vivo

(2017) Tiancong Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Strategy Toward Highly Fluorogenic Bioprobes Emitting across the Visible Spectrum

(2017) Haoliang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ formation of pyronin dyes for fluorescence protease sensing

(2017) Sylvain Debieu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue

(2017) Alicia Megia-Fernandez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe

(2017) Xinyuan He et al.   Chemical Science

Light-up probe based on AIEgens: dual signal turn-on for caspase cascade activation monitoring

(2017) Youyong Yuan et al.   Chemical Science

Sensitive in vivo Visualization of Breast Cancer Using Ratiometric Protease-activatable Fluorescent Imaging Agent, AVB-620

(2017) Marcel Miampamba et al.   Theranostics

Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes

(2017) Ori Green et al.   ACS Central Science

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

(2017) Anniek den Hamer et al.   ACS Sensors

Ultrasensitive tumour-penetrating nanosensors of protease activity

(2017) Ester J. Kwon et al.   Nature Biomedical Engineering

Förster resonance energy transfer: Role of diffusion of fluorophore orientation and separation in observed shifts of FRET efficiency

(2017) Bram Wallace et al.   PLoS One

A FRET-based biosensor for the detection of neutrophil elastase

(2016) C. Schulenburg et al.   ANALYST

Ultrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells

(2016) Qiuyu Gong et al.   ANALYTICAL CHEMISTRY

Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells

(2016) Yuqi Wang et al.   ANALYTICAL CHEMISTRY

Protease-Responsive Prodrug with Aggregation-Induced Emission Probe for Controlled Drug Delivery and Drug Release Tracking in Living Cells

(2016) Yong Cheng et al.   ANALYTICAL CHEMISTRY

Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells

(2016) Wei Liu et al.   ANALYTICAL CHEMISTRY

A colorimetric protease activity assay method using engineered procaspase-3 enzymes

(2016) Dokyung Yang et al.   Analytical Methods

Sensing Enzymatic Activity by Exposure and Selection of DNA-Encoded Probes

(2016) Rachael R. Jetson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging Designs of Activatable Photoacoustic Probes for Molecular Imaging

(2016) Qingqing Miao et al.   BIOCONJUGATE CHEMISTRY

Rapid colorimetric sensing platform for the detection of Listeria monocytogenes foodborne pathogen

(2016) Sahar Alhogail et al.   BIOSENSORS & BIOELECTRONICS

An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification

(2016) Ding Wang et al.   CHEMICAL COMMUNICATIONS

A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

(2016) Yi Wang et al.   CHEMICAL COMMUNICATIONS

Photo-click construction of a targetable and activatable two-photon probe imaging protease in apoptosis

(2016) Mi Zhou et al.   CHEMICAL COMMUNICATIONS

Excited-state intramolecular proton-transfer (ESIPT)-inspired solid state emitters

(2016) Vikas S. Padalkar et al.   CHEMICAL SOCIETY REVIEWS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Concurrent Modulation of Quantum Dot Photoluminescence Using a Combination of Charge Transfer and Förster Resonance Energy Transfer: Competitive Quenching and Multiplexed Biosensing Modality

(2016) W. Russ Algar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remarkable Enhancement of Chemiluminescent Signal by Dioxetane–Fluorophore Conjugates: Turn-ON Chemiluminescence Probes with Color Modulation for Sensing and Imaging

(2016) Nir Hananya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Contrast agents for molecular photoacoustic imaging

(2016) Judith Weber et al.   NATURE METHODS

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

(2016) Melodi Javid Whitley et al.   Science Translational Medicine

Pyroglutamate aminopeptidase 1 may be an indicator of cellular inflammatory response as revealed using a sensitive long-wavelength fluorescent probe

(2016) Qiuyu Gong et al.   Chemical Science

A FRET probe with AIEgen as the energy quencher: dual signal turn-on for self-validated caspase detection

(2016) Youyong Yuan et al.   Chemical Science

Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe

(2016) Qiuyu Gong et al.   Chemical Science

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging

(2016) Takahiro Kuchimaru et al.   Nature Communications

Aggregation-induced emission—fluorophores and applications

(2016) Yuning Hong   Methods and Applications in Fluorescence

Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV

(2016) Haruna Onoyama et al.   Scientific Reports

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

(2015) Leslie O. Ofori et al.   ACS Chemical Biology

Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors

(2015) Yi Hou et al.   ACS Nano

A Dual-FRET-Based Versatile Prodrug for Real-Time Drug Release Monitoring and In Situ Therapeutic Efficacy Evaluation

(2015) Shi-Ying Li et al.   ADVANCED FUNCTIONAL MATERIALS

Light-Up Probe for Targeted and Activatable Photodynamic Therapy with Real-Time In Situ Reporting of Sensitizer Activation and Therapeutic Responses

(2015) Youyong Yuan et al.   ADVANCED FUNCTIONAL MATERIALS

In Situ Formation of Nanofibers from Purpurin18-Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites

(2015) Di Zhang et al.   ADVANCED MATERIALS

Concentric Förster Resonance Energy Transfer Imaging

(2015) Miao Wu et al.   ANALYTICAL CHEMISTRY

Colorimetric Assay for the Detection of Typical Biomarkers for Periodontitis Using a Magnetic Nanoparticle Biosensor

(2015) Shayalini Wignarajah et al.   ANALYTICAL CHEMISTRY

Sensitive cell apoptosis assay based on caspase-3 activity detection with graphene oxide-assisted electrochemical signal amplification

(2015) Hongxia Chen et al.   BIOSENSORS & BIOELECTRONICS

A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3

(2015) Shi-Ying Li et al.   CHEMICAL COMMUNICATIONS

Aptamer-free electrochemical detection of thrombin based on coagulation reaction of ferrocene-labeled fibrinogen

(2015) Hyunjun Ko et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

A simple and label-free electrochemical method for detection of beta-site amyloid precursor protein cleaving enzyme and screening of its inhibitor

(2015) Ning Xia et al.   SENSORS AND ACTUATORS B-CHEMICAL

Tetraphenylpyrazine-based AIEgens: facile preparation and tunable light emission

(2015) Ming Chen et al.   Chemical Science

Differential Expression and Enzymatic Activity of DPPIV/CD26 Affects Migration Ability of Cervical Carcinoma Cells

(2015) Aline Beckenkamp et al.   PLoS One

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

(2015) Paulina Kasperkiewicz et al.   PLoS One

Poly β-Cyclodextrin/TPdye Nanomicelle-based Two-Photon Nanoprobe for Caspase-3 Activation Imaging in Live Cells and Tissues

(2014) Huijuan Yan et al.   ANALYTICAL CHEMISTRY

A Dual-Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multiparametric Bioluminescence Imaging

(2014) Amit P. Jathoul et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific Light-Up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for the Targeted and Image-Guided Photodynamic Ablation of Cancer Cells

(2014) Youyong Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative electrochemical detection of cathepsin B activity in complex tissue lysates using enhanced AC voltammetry at carbon nanofiber nanoelectrode arrays

(2014) Luxi Z. Swisher et al.   BIOSENSORS & BIOELECTRONICS

Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors

(2014) Erin E. Mulvihill et al.   ENDOCRINE REVIEWS

Isobaric Labeling-Based Relative Quantification in Shotgun Proteomics

(2014) Navin Rauniyar et al.   JOURNAL OF PROTEOME RESEARCH

Targeted Theranostic Platinum(IV) Prodrug with a Built-In Aggregation-Induced Emission Light-Up Apoptosis Sensor for Noninvasive Early Evaluation of Its Therapeutic Responses in Situ

(2014) Youyong Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

(2014) Deju Ye et al.   Nature Chemistry

A synthetic luciferin improves bioluminescence imaging in live mice

(2014) Melanie S Evans et al.   NATURE METHODS

Design strategies for bioorthogonal smart probes

(2014) Peyton Shieh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Colorimetric protease assay by using gold nanoparticles and oligopeptides

(2014) Xiaokang Ding et al.   SENSORS AND ACTUATORS B-CHEMICAL

A general colorimetric method for detecting protease activity based on peptide-induced gold nanoparticle aggregation

(2014) Ganchao Chen et al.   RSC Advances

Visualization of Protease Activity In Vivo Using an Activatable Photo-Acoustic Imaging Probe Based on CuS Nanoparticles

(2014) Kai Yang et al.   Theranostics

A New Method to Assay Protease Based on Amyloid Misfolding: Application to Prostate Cancer Diagnosis Using a Panel of Proteases Biomarkers

(2014) Hao Li et al.   Theranostics

Ultra-rapid colorimetric assay for protease detection using magnetic nanoparticle-based biosensors

(2013) Ghadeer A. R. Y. Suaifan et al.   ANALYST

Non-Peptide-Based Fluorogenic Small-Molecule Probe for Elastase

(2013) Qi Sun et al.   ANALYTICAL CHEMISTRY

A simple and general approach to assay protease activity with electrochemical technique

(2013) Ya Cao et al.   BIOSENSORS & BIOELECTRONICS

The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry

(2013) Devatha P. Nair et al.   CHEMISTRY OF MATERIALS

Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats

(2013) Angelo Pietro Femia et al.   INTERNATIONAL JOURNAL OF CANCER

Activatable Oligomerizable Imaging Agents for Photoacoustic Imaging of Furin-Like Activity in Living Subjects

(2013) Anca Dragulescu-Andrasi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation

(2013) Genevieve C. Van de Bittner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptide functionalized gold nanoparticles for colorimetric detection of matrilysin (MMP-7) activity

(2013) Peng Chen et al.   Nanoscale

Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

(2013) Nicolaos Avlonitis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light

(2013) Satoshi Iwano et al.   TETRAHEDRON

Light-up bioprobe with aggregation-induced emission characteristics for real-time apoptosis imaging in target cancer cells

(2013) Dan Ding et al.   Journal of Materials Chemistry B

A novel electrochemical biosensor for highly selective detection of protease biomarker from Bacillus licheniformis with d-amino acid containing peptide

(2012) Huiwang Wu et al.   ANALYST

Comparison of enhanced bioluminescence energy transfer donors for protease biosensors

(2012) Helen Dacres et al.   ANALYTICAL BIOCHEMISTRY

Micropatterned Surfaces Functionalized with Electroactive Peptides for Detecting Protease Release from Cells

(2012) Dong-Sik Shin et al.   ANALYTICAL CHEMISTRY

The first ratiometric fluorescent probe for aminopeptidase N

(2012) Laizhong Chen et al.   Analytical Methods

Rational Design and Development of Near-Infrared-Emitting Firefly Luciferins Available In Vivo

(2012) Ryosuke Kojima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ratiometric Activatable Cell-Penetrating Peptides Provide Rapid In Vivo Readout of Thrombin Activation

(2012) Michael Whitney et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters

(2012) Stefanie Gehrig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Colorimetric assay of matrix metalloproteinase activity based on metal-induced self-assembly of carboxy gold nanoparticles

(2012) Gae Baik Kim et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical detection of the activities of thrombin and its inhibitor

(2012) Ji Ji et al.   ELECTROCHEMISTRY COMMUNICATIONS

Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability

(2012) Peter Findeisen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization

(2012) Masayo Sakabe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

A sensitive colorimetric label-free assay for trypsin and inhibitor screening with gold nanoparticles

(2011) Wangxin Xue et al.   ANALYST

Localized surface plasmon resonance: Nanostructures, bioassays and biosensing—A review

(2011) Eleonora Petryayeva et al.   ANALYTICA CHIMICA ACTA

Conjugate Addition/Cyclization Sequence Enables Selective and Simultaneous Fluorescence Detection of Cysteine and Homocysteine

(2011) Xiaofeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles

(2011) Yuliang Pan et al.   CHEMICAL COMMUNICATIONS

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

(2011) Yiyun Cheng et al.   CHEMICAL SOCIETY REVIEWS

Multispectral Optoacoustic Tomography of Matrix Metalloproteinase Activity in Vulnerable Human Carotid Plaques

(2011) Daniel Razansky et al.   MOLECULAR IMAGING AND BIOLOGY

Functional protease profiling for diagnosis of malignant disease

(2011) Peter Findeisen et al.   Proteomics Clinical Applications

Rapid Cancer Detection by Topically Spraying a  -Glutamyltranspeptidase-Activated Fluorescent Probe

(2011) Y. Urano et al.   Science Translational Medicine

Peptide-based molecular beacons for cancer imaging and therapy

(2010) Tracy W. B. Liu et al.   AMINO ACIDS

Selective and Sensitive Monitoring of Caspase-1 Activity by a Novel Bioluminescent Activity-Based Probe

(2010) Maik Kindermann et al.   CHEMISTRY & BIOLOGY

Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology

(2010) Natasha Thorne et al.   CHEMISTRY & BIOLOGY

Endoprotease Profiling with Double-Tagged Peptide Substrates: A New Diagnostic Approach in Oncology

(2010) T. Peccerella et al.   CLINICAL CHEMISTRY

Design, Synthesis, and Imaging of an Activatable Photoacoustic Probe

(2010) Jelena Levi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates

(2009) Anca Dragulescu-Andrasi et al.   BIOCONJUGATE CHEMISTRY

Multispectral Near-Infrared Fluorescence Molecular Imaging of Matrix Metalloproteinases in a Human Carotid Plaque Using a Matrix-Degrading Metalloproteinase–Sensitive Activatable Fluorescent Probe

(2009) Bastiaan M. Wallis de Vries et al.   CIRCULATION

Self-cleavable chemiluminescent probes suitable for protease sensing

(2009) Jean-Alexandre Richard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Spiking of serum specimens with exogenous reporter peptides for mass spectrometry based protease profiling as diagnostic tool

(2008) Peter Findeisen et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY