Synthesis and Toxicity of Graphene Oxide Nanoparticles: A Literature Review of In Vitro and In Vivo Studies

Graphene oxide induces dose‑dependent lung injury in rats by regulating autophagy

(2021) Lei Zhang et al.   Experimental and Therapeutic Medicine

Evaluating the cytotoxicity of graphene oxide using embryonic stem cells‐derived cells

(2020) Le Hu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing

(2020) Yongping Liang et al.   BIOMACROMOLECULES

Graphene oxide and reduced graphene oxide-based scaffolds in regenerative medicine

(2020) Ahmed Raslan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Secondary toxic effect of graphene oxide and graphene quantum dots alters the expression of miR-21 and miR-29a in human cell lines

(2020) Mahnaz Sadat Hashemi et al.   TOXICOLOGY IN VITRO

Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae

(2020) Zigang Cao et al.   CHEMOSPHERE

Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing

(2020) Meng Li et al.   CHEMISTRY OF MATERIALS

Biochemical toxicity, lysosomal membrane stability and DNA damage induced by graphene oxide in earthworms

(2020) Shulan Zhao et al.   ENVIRONMENTAL POLLUTION

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

(2019) Yongping Liang et al.   Small

Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery

(2019) Nuzhat Zahin et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

In vitro cardiotoxicity evaluation of graphene oxide

(2019) Marcelo Dutra Arbo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Graphene Oxide Flakes Tune Excitatory Neurotransmission in Vivo by Targeting Hippocampal Synapses

(2019) Rossana Rauti et al.   NANO LETTERS

Graphene oxide induces cardiovascular defects in developing zebrafish (Danio rerio) embryo model: In-vivo toxicity assessment

(2019) Manjunatha Bangeppagari et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Estimation of genomic instability and mutation induction by graphene oxide nanoparticles in mice liver and brain tissues

(2019) Hanan R. H. Mohamed et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Conductive biomaterials for muscle tissue engineering

(2019) Ruonan Dong et al.   BIOMATERIALS

Graphene oxide-induced neurotoxicity on neurotransmitters, AFD neurons and locomotive behavior in Caenorhabditis elegans

(2019) Mina Kim et al.   NEUROTOXICOLOGY

Direct observation of oxygen configuration on individual graphene oxide sheets

(2018) Zilong Liu et al.   CARBON

Non-covalent functionalized graphene oxide (GO) adsorbent with an organic gelator for co-adsorption of dye, endocrine-disruptor, pharmaceutical and metal ion

(2018) Mingqian Lv et al.   CHEMICAL ENGINEERING JOURNAL

Monolithic Crystalline Swelling of Graphite Oxide: A Bridge to Ultralarge Graphene Oxide with High Scalability

(2018) Jiajia Zhang et al.   CHEMISTRY OF MATERIALS

Biotransformation and Biological Interaction of Graphene and Graphene Oxide during Simulated Oral Ingestion

(2018) Daniela Guarnieri et al.   Small

The biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and bioactivities toward immune cells

(2018) Yu Qi et al.   NPG Asia Materials

In vivo toxicological evaluation of graphene oxide nanoplatelets for clinical application

(2018) Mohammad Amrollahi-Sharifabadi et al.   International Journal of Nanomedicine

Systematic assessment of the toxicity and potential mechanism of graphene derivatives in vitro and in vivo

(2018) Jian Li et al.   TOXICOLOGICAL SCIENCES

Graphene oxide nanosheets induced genotoxicity and pulmonary injury in mice

(2017) Nabil A. El-Yamany et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Biotransformation of graphene oxide nanosheets in blood plasma affects their interactions with cells

(2017) Xiangang Hu et al.   Environmental Science-Nano

Functionalized Graphene Oxide with Chitosan for Protein Nanocarriers to Protect against Enzymatic Cleavage and Retain Collagenase Activity

(2017) Fatemeh Emadi et al.   Scientific Reports

Glucose-Derived Carbonaceous Nanospheres for Photoacoustic Imaging and Photothermal Therapy

(2016) Zhao-Hua Miao et al.   ACS Applied Materials & Interfaces

The Effects of Extensive Glomerular Filtration of Thin Graphene Oxide Sheets on Kidney Physiology

(2016) Dhifaf A. Jasim et al.   ACS Nano

Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish

(2016) Minjie Chen et al.   AQUATIC TOXICOLOGY

Interaction of graphene oxide with albumins: Effect of size, pH, and temperature

(2016) M. Šimšíková   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro

(2016) Stefan Bengtson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat

(2016) Yingbo Li et al.   International Journal of Environmental Research and Public Health

Toxicity Evaluation of Graphene Oxide in Kidneys of Sprague-Dawley Rats

(2016) Anita Patlolla et al.   International Journal of Environmental Research and Public Health

Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

(2016) Sandeep Mittal et al.   Scientific Reports

Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals

(2015) Juan Ma et al.   ACS Nano

Recent progress in applications of graphene oxide for gas sensing: A review

(2015) Kei Toda et al.   ANALYTICA CHIMICA ACTA

Effects of graphene oxide on the development of offspring mice in lactation period

(2015) Changhui Fu et al.   BIOMATERIALS

High-yield preparation of graphene oxide from small graphite flakes via an improved Hummers method with a simple purification process

(2015) Ji Chen et al.   CARBON

Ecotoxicological effects of graphene oxide on the protozoan Euglena gracilis

(2015) Changwei Hu et al.   CHEMOSPHERE

Carbon Nanomaterials for Drug Delivery and Cancer Therapy

(2015) Mrinmay Chakrabarti et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Spectroscopy and Fluorescence Lifetime Imaging Microscopy To Probe the Interaction of Bovine Serum Albumin with Graphene Oxide

(2015) Jagannath Kuchlyan et al.   LANGMUIR

Temperature influence on the synthesis of pristine graphene oxide and graphite oxide

(2015) Flavio Pendolino et al.   MATERIALS CHEMISTRY AND PHYSICS

Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film

(2015) Qinglin Hu et al.   Nanoscale

Reproductive and developmental toxicity of carbon-based nanomaterials: A literature review

(2015) Makoto Ema et al.   Nanotoxicology

Specific nanotoxicity of graphene oxide during zebrafish embryogenesis

(2015) Yuming Chen et al.   Nanotoxicology

Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation

(2015) Liang Mao et al.   Particle and Fibre Toxicology

An iron-based green approach to 1-h production of single-layer graphene oxide

(2015) Li Peng et al.   Nature Communications

Deoxygenation of graphene oxide using household baking soda as a reducing agent: a green approach

(2015) M. T. H. Aunkor et al.   RSC Advances

Pulmonary Responses of Sprague-Dawley Rats in Single Inhalation Exposure to Graphene Oxide Nanomaterials

(2015) Sung Gu Han et al.   Biomed Research International

Reduced graphene oxide induces transient blood–brain barrier opening: an in vivo study

(2015) Monique Culturato Padilha Mendonça et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo

(2015) Feng Zhao et al.   Science Bulletin

Dual Roles of Graphene Oxide in Chondrogenic Differentiation of Adult Stem Cells: Cell-Adhesion Substrate and Growth Factor-Delivery Carrier

(2014) Hee Hun Yoon et al.   ADVANCED FUNCTIONAL MATERIALS

Controlled release of doxorubicin from graphene oxide based charge-reversal nanocarrier

(2014) Ting Zhou et al.   BIOMATERIALS

Nanotoxicity of Graphene and Graphene Oxide

(2014) Amedea B. Seabra et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Simple Synthesis of Graphene Oxide Using Ultrasonic Cleaner from Expanded Graphite

(2014) Hongjun Yang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

(2014) Bo Li et al.   International Journal of Nanomedicine

Effects of the oxidation degree of graphene oxide on the adsorption of methylene blue

(2014) Han Yan et al.   JOURNAL OF HAZARDOUS MATERIALS

Preparation and Characterization of Graphene Oxide

(2014) Jianguo Song et al.   Journal of Nanomaterials

Reproductive toxicity of nanoscale graphene oxide in male mice

(2014) Shanlu Liang et al.   Nanotoxicology

Graphene Oxide Triggers Toll-Like Receptors/Autophagy Responses In Vitro and Inhibits Tumor Growth In Vivo

(2014) Guan-Yu Chen et al.   Advanced Healthcare Materials

Biomedical Applications of Graphene and Graphene Oxide

(2013) Chul Chung et al.   ACCOUNTS OF CHEMICAL RESEARCH

Organic Solvent-Based Graphene Oxide Liquid Crystals: A Facile Route toward the Next Generation of Self-Assembled Layer-by-Layer Multifunctional 3D Architectures

(2013) Rouhollah Jalili et al.   ACS Nano

In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration

(2013) Kai Yang et al.   BIOMATERIALS

Olanzapine Loaded Cationic Solid Lipid Nanoparticles for Improved Oral Bioavailability

(2013) Sumeet Sood et al.   Current Nanoscience

Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells

(2013) Anxin Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Mass production of graphene oxide from expanded graphite

(2013) Ling Sun et al.   MATERIALS LETTERS

Raman spectroscopy as a versatile tool for studying the properties of graphene

(2013) Andrea C. Ferrari et al.   Nature Nanotechnology

Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice

(2013) Bo Li et al.   NPG Asia Materials

Graphene oxide can induce in vitro and in vivo mutagenesis

(2013) Yuanyuan Liu et al.   Scientific Reports

Graphene Oxide-Based Antibacterial Cotton Fabrics

(2013) Jinming Zhao et al.   Advanced Healthcare Materials

Differences in the Biokinetics of Inhaled Nano- versus Micrometer-Sized Particles

(2012) Wolfgang G. Kreyling et al.   ACCOUNTS OF CHEMICAL RESEARCH

Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets

(2012) Qingxin Mu et al.   ACS Applied Materials & Interfaces

Graphene Oxide. Origin of Acidity, Its Instability in Water, and a New Dynamic Structural Model

(2012) Ayrat M. Dimiev et al.   ACS Nano

Amine-Modified Graphene: Thrombo-Protective Safer Alternative to Graphene Oxide for Biomedical Applications

(2012) Sunil K. Singh et al.   ACS Nano

The role of the lateral dimension of graphene oxide in the regulation of cellular responses

(2012) Hua Yue et al.   BIOMATERIALS

Preparation of the Hybrid Film of Poly(allylamine hydrochloride)-Functionalized Graphene Oxide and Gold Nanoparticle and Its Application for Laser-Induced Desorption/Ionization of Small Molecules

(2012) Young-Kwan Kim et al.   LANGMUIR

Water Desalination across Nanoporous Graphene

(2012) David Cohen-Tanugi et al.   NANO LETTERS

Effect of size and dose on the biodistribution of graphene oxide in mice

(2012) Jia-Hui Liu et al.   Nanomedicine

Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line

(2012) Min Lv et al.   Nanoscale

A one-step method for reduction and self-assembling of graphene oxide into reduced graphene oxide aerogels

(2012) Mingxi Chen et al.   Journal of Materials Chemistry A

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond

(2012) Xiaoyong Zhang et al.   Toxicology Research

Cytotoxicity of Graphene Oxide and Graphene in Human Erythrocytes and Skin Fibroblasts

(2011) Ken-Hsuan Liao et al.   ACS Applied Materials & Interfaces

Graphene Oxide: A Nonspecific Enhancer of Cellular Growth

(2011) Oscar N. Ruiz et al.   ACS Nano

Protein Corona-Mediated Mitigation of Cytotoxicity of Graphene Oxide

(2011) Wenbing Hu et al.   ACS Nano

Thrombus Inducing Property of Atomically Thin Graphene Oxide Sheets

(2011) Sunil K. Singh et al.   ACS Nano

The Real Graphene Oxide Revealed: Stripping the Oxidative Debris from the Graphene-like Sheets

(2011) Jonathan P. Rourke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A graphene-based platform for induced pluripotent stem cells culture and differentiation

(2011) G.-Y. Chen et al.   BIOMATERIALS

Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review

(2011) Vanesa C. Sanchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

(2011) Stephanie Hirn et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Adsorption of nitrogen oxides on graphene and graphene oxides: Insights from density functional calculations

(2011) Shaobin Tang et al.   JOURNAL OF CHEMICAL PHYSICS

Facile synthesis of silver@graphene oxide nanocomposites and their enhanced antibacterial properties

(2011) Wei-Ping Xu et al.   JOURNAL OF MATERIALS CHEMISTRY

Minimizing Oxidation and Stable Nanoscale Dispersion Improves the Biocompatibility of Graphene in the Lung

(2011) Matthew C. Duch et al.   NANO LETTERS

Fast DNA sequencing with a graphene-based nanochannel device

(2011) Seung Kyu Min et al.   Nature Nanotechnology

Graphene and graphene oxide: biofunctionalization and applications in biotechnology

(2011) Ying Wang et al.   TRENDS IN BIOTECHNOLOGY

Cytotoxicity Effects of Graphene and Single-Wall Carbon Nanotubes in Neural Phaeochromocytoma-Derived PC12 Cells

(2010) Yongbin Zhang et al.   ACS Nano

Mechanical Properties of Monolayer Graphene Oxide

(2010) Ji Won Suk et al.   ACS Nano

Behaviors of NIH-3T3 Fibroblasts on Graphene/Carbon Nanotubes: Proliferation, Focal Adhesion, and Gene Transfection Studies

(2010) Soo-Ryoon Ryoo et al.   ACS Nano

Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria

(2010) Omid Akhavan et al.   ACS Nano

Improved Synthesis of Graphene Oxide

(2010) Daniela C. Marcano et al.   ACS Nano

Graphene and Graphene Oxide: Synthesis, Properties, and Applications

(2010) Yanwu Zhu et al.   ADVANCED MATERIALS

Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration

(2010) Xiaoyong Zhang et al.   CARBON

Dye Adsorption on Layered Graphite Oxide

(2010) Philip Bradder et al.   JOURNAL OF CHEMICAL AND ENGINEERING DATA

Aptamer/Graphene Oxide Nanocomplex forin SituMolecular Probing in Living Cells

(2010) Ying Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatibility of Graphene Oxide

(2010) Kan Wang et al.   Nanoscale Research Letters

Graphene transistors

(2010) Frank Schwierz   Nature Nanotechnology

Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation

(2010) Ilse Gosens et al.   Particle and Fibre Toxicology

Deposition and biokinetics of inhaled nanoparticles

(2010) Marianne Geiser et al.   Particle and Fibre Toxicology

In vitro toxicity evaluation of graphene oxide on A549 cells

(2010) Yanli Chang et al.   TOXICOLOGY LETTERS

Synthesis of Graphene Sheets with High Electrical Conductivity and Good Thermal Stability by Hydrogen Arc Discharge Exfoliation

(2009) Zhong-Shuai Wu et al.   ACS Nano

The chemistry of graphene oxide

(2009) Daniel R. Dreyer et al.   CHEMICAL SOCIETY REVIEWS

Chemical methods for the production of graphenes

(2009) Sungjin Park et al.   Nature Nanotechnology

Fracture and Fatigue in Graphene Nanocomposites

(2009) Mohammed A. Rafiee et al.   Small

Extremely high thermal conductivity of graphene: Prospects for thermal management applications in nanoelectronic circuits

(2008) S. Ghosh et al.   APPLIED PHYSICS LETTERS

Characterisation and in vivo ecotoxicity evaluation of double-wall carbon nanotubes in larvae of the amphibian Xenopus laevis

(2008) F MOUCHET et al.   AQUATIC TOXICOLOGY

Environmental behavior and ecotoxicity of engineered nanoparticles to algae, plants, and fungi

(2008) Enrique Navarro et al.   ECOTOXICOLOGY

Facile Synthesis and Characterization of Graphene Nanosheets

(2008) Guoxiu Wang et al.   Journal of Physical Chemistry C

PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs

(2008) Zhuang Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Graphene Oxide Dispersions in Organic Solvents

(2008) J. I. Paredes et al.   LANGMUIR

Fine Structure Constant Defines Visual Transparency of Graphene

(2008) R. R. Nair et al.   SCIENCE