Current state of the art for enhancing urine biomarker discovery

Development and validation of a CE-MS method for the targeted assessment of amino acids in urine

(2016) Karina T. Rodrigues et al.   ELECTROPHORESIS

Peptide-conjugated glass slides for selective capture and purification of diagnostic cells: Applications in urine cytology

(2016) Danuta B. Wronska et al.   BIOTECHNIQUES

Analytical Performance of ELISA Assays in Urine: One More Bottleneck towards Biomarker Validation and Clinical Implementation

(2016) Despina Chatziharalambous et al.   PLoS One

Widening and Diversifying the Proteome Capture by Combinatorial Peptide Ligand Libraries via Alcian Blue Dye Binding

(2015) Giovanni Candiano et al.   ANALYTICAL CHEMISTRY

An Empirical Approach to Signature Peptide Choice for Selected Reaction Monitoring: Quantification of Uromodulin in Urine

(2015) Q. Fu et al.   CLINICAL CHEMISTRY

Thermoresponsive hydrogels in biomedical applications

(2015) Leda Klouda   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Recent progress in urinary proteome analysis for prostate cancer diagnosis and management

(2015) Maria Frantzi et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Physiological conditions can be reflected in human urine proteome and metabolome

(2015) Jianqiang Wu et al.   Expert Review of Proteomics

Urinary Proteome and Systolic Blood Pressure as Predictors of 5-Year Cardiovascular and Cardiac Outcomes in a General PopulationNovelty and Significance

(2015) Zhen-Yu Zhang et al.   HYPERTENSION

Cellulose Acetate Membrane Electrophoresis Based Urinary Proteomics for the Identification of Characteristic Proteins

(2015) Aki Nakayama et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer

(2015) Jan Muntel et al.   JOURNAL OF PROTEOME RESEARCH

Longitudinal Urinary Protein Variability in Participants of the Space Flight Simulation Program

(2015) Nina A. Khristenko et al.   JOURNAL OF PROTEOME RESEARCH

From hundreds to thousands: Widening the normal human Urinome (1)

(2015) Laura Santucci et al.   Journal of Proteomics

Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis

(2015) Ruben Magni et al.   Journal of Translational Medicine

A Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections (CAUTIs)

(2015) Christian Lassek et al.   MOLECULAR & CELLULAR PROTEOMICS

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

(2015) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic biomarkers in kidney disease: issues in development and implementation

(2015) Harald Mischak et al.   Nature Reviews Nephrology

Precision Medicine — Personalized, Problematic, and Promising

(2015) J. Larry Jameson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Proteomic Analysis of Individual and Gender Variations in Normal Human Urine and Cerebrospinal Fluid Using iTRAQ Quantification

(2015) Zhengguang Guo et al.   PLoS One

Proteomics analysis of bodily fluids in pancreatic cancer

(2015) Sheng Pan et al.   PROTEOMICS

An analysis of the impact of pre-analytical factors on the urine proteome: Sample processing time, temperature, and proteolysis

(2015) Sophie Hepburn et al.   Proteomics Clinical Applications

Effect of transient blood glucose increases after oral glucose intake on the human urinary proteome

(2015) Menglin Li et al.   Proteomics Clinical Applications

Development of a Targeted Urine Proteome Assay for kidney diseases

(2015) Lloyd G. Cantley et al.   Proteomics Clinical Applications

Urinary proteomic biomarkers to predict cardiovascular events

(2015) Catriona E. Brown et al.   Proteomics Clinical Applications

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Permanent proteins in the urine of healthy humans during the Mars-500 experiment

(2015) Irina M. Larina et al.   Journal of Bioinformatics and Computational Biology

Time-course human urine proteomics in space-flight simulation experiments

(2015) Hans Binder et al.   BMC GENOMICS

Two Urinary Peptides Associated Closely With Type 2 Diabetes Mellitus

(2015) Man Zhang et al.   PLoS One

Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine

(2015) Szymon Filip et al.   PLoS One

Validation of a Novel Collection Device for Non-Invasive Urine Sampling from Free-Ranging Animals

(2015) Lisa Michelle Danish et al.   PLoS One

Combinatorial Peptide Ligand Libraries as a “Trojan Horse” in Deep Discovery Proteomics

(2014) Pier Giorgio Righetti et al.   ANALYTICAL CHEMISTRY

Method Validation for Preparing Urine Samples for Downstream Proteomic and Metabolomic Applications

(2014) Wim Ammerlaan et al.   BIOPRESERVATION AND BIOBANKING

The identification of tuberculosis biomarkers in human urine samples

(2014) B. L. Young et al.   EUROPEAN RESPIRATORY JOURNAL

The urinary proteome and peptidome of renal cell carcinoma patients: a comparison of different techniques

(2014) Francesca Raimondo et al.   Expert Review of Proteomics

Urine sample preparation for proteomic analysis

(2014) Pawel Olszowy et al.   JOURNAL OF SEPARATION SCIENCE

N-linked (N-) Glycoproteomics of Urimary Exosomes*

(2014) Mayank Saraswat et al.   MOLECULAR & CELLULAR PROTEOMICS

Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy

(2014) Justyna Siwy et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

UniProt: a hub for protein information

(2014)   NUCLEIC ACIDS RESEARCH

Identification of Urinary Peptide Biomarkers Associated with Rheumatoid Arthritis

(2014) Angelique Stalmach et al.   PLoS One

How to submit MS proteomics data to ProteomeXchange via the PRIDE database

(2014) Tobias Ternent et al.   PROTEOMICS

Use of a Novel Chagas Urine Nanoparticle Test (Chunap) for Diagnosis of Congenital Chagas Disease

(2014) Yagahira E. Castro-Sesquen et al.   PLoS Neglected Tropical Diseases

Urine proteomes of healthy aging humans reveal extracellular matrix (ECM) alterations and immune system dysfunction

(2013) M. Bakun et al.   AGE

An in-depth comparison of the male pediatric and adult urinary proteomes

(2013) John W. Froehlich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Urine as a source for clinical proteome analysis: From discovery to clinical application

(2013) Eva Rodríguez-Suárez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Peptidomics of Urine and Other Biofluids for Cancer Diagnostics

(2013) J. M. Bauca et al.   CLINICAL CHEMISTRY

Validation of Uromodulin as a Candidate Gene for Human Essential Hypertension

(2013) Lesley A. Graham et al.   HYPERTENSION

Combinatorial ligand libraries as a two-dimensional method for proteome analysis

(2013) Laura Santucci et al.   JOURNAL OF CHROMATOGRAPHY A

State of the Human Proteome in 2013 as Viewed through PeptideAtlas: Comparing the Kidney, Urine, and Plasma Proteomes for the Biology- and Disease-Driven Human Proteome Project

(2013) Terry Farrah et al.   JOURNAL OF PROTEOME RESEARCH

The effect of common uromodulin variants on urinary protein level and gene transcription

(2013) Luca Rampoldi et al.   KIDNEY INTERNATIONAL

Albumin testing in urine using a smart-phone

(2013) Ahmet F. Coskun et al.   LAB ON A CHIP

The GlycoFilter: A Simple and Comprehensive Sample Preparation Platform for Proteomics, N-Glycomics and Glycosylation Site Assignment

(2013) Hui Zhou et al.   MOLECULAR & CELLULAR PROTEOMICS

Cystatin C versus Creatinine in Determining Risk Based on Kidney Function

(2013) Michael G. Shlipak et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Extensive Targeted Proteomic Analysis of Disease-Related Protein Biomarkers in Urine from Healthy Donors

(2013) Brian M. Nolen et al.   PLoS One

Proteasix: A tool for automated and large-scale prediction of proteases involved in naturally occurring peptide generation

(2013) Julie Klein et al.   PROTEOMICS

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

Novel Serum and Urine Markers for Pediatric Appendicitis

(2012) Anupam B. Kharbanda et al.   ACADEMIC EMERGENCY MEDICINE

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

(2012) Marcus Bantscheff et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience

(2012) Harald Mischak et al.   CLINICAL BIOCHEMISTRY

Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction

(2012) T. Kuznetsova et al.   EUROPEAN HEART JOURNAL

Implementation of proteomic biomarkers: making it work

(2012) Harald Mischak et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Interlaboratory Reproducibility of Selective Reaction Monitoring Assays Using Multiple Upfront Analyte Enrichment Strategies

(2012) Amol Prakash et al.   JOURNAL OF PROTEOME RESEARCH

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Combinatorial peptide ligand libraries for the analysis of low-expression proteins: Validation for normal urine and definition of a first protein MAP

(2012) Laura Santucci et al.   PROTEOMICS

How to get proteomics to the clinic? Issues in clinical proteomics, exemplified by CE-MS

(2012) Harald Mischak   Proteomics Clinical Applications

Combinatorial peptide ligand libraries: The conquest of the ‘hidden proteome’ advances at great strides

(2011) Pier Giorgio Righetti et al.   ELECTROPHORESIS

Clinical application of urinary proteomics/peptidomics

(2011) Amaya Albalat et al.   Expert Review of Proteomics

Urinary Proteomics for Prediction of Preeclampsia

(2011) David M. Carty et al.   HYPERTENSION

Improvements in Proteomic Metrics of Low Abundance Proteins through Proteome Equalization Using ProteoMiner Prior to MudPIT

(2011) Bryan R. Fonslow et al.   JOURNAL OF PROTEOME RESEARCH

A Comprehensive Map of the Human Urinary Proteome

(2011) Arivusudar Marimuthu et al.   JOURNAL OF PROTEOME RESEARCH

Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer

(2011) Rong Meng et al.   Journal of Proteomics

“Cheek-to-cheek” urinary proteome profiling via combinatorial peptide ligand libraries: A novel, unexpected elution system

(2011) Giovanni Candiano et al.   Journal of Proteomics

Multifunctional Core–Shell Nanoparticles: Discovery of Previously Invisible Biomarkers

(2011) Davide Tamburro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care

(2011) ShuQi. Wang et al.   LAB ON A CHIP

Human Urinary Glycoproteomics; Attachment Site Specific Analysis ofN- andO-Linked Glycosylations by CID and ECD

(2011) Adnan Halim et al.   MOLECULAR & CELLULAR PROTEOMICS

Toward a standardized urine proteome analysis methodology

(2011) Magali Court et al.   PROTEOMICS

Female urinary proteomics: New insight into exogenous and physiological hormone-dependent changes

(2011) Annalisa Castagna et al.   Proteomics Clinical Applications

Human urinary peptide database for multiple disease biomarker discovery

(2011) Justyna Siwy et al.   Proteomics Clinical Applications

Infrared spectroscopic analysis of human interstitial fluid in vitro and in vivo using FT-IR spectroscopy and pulsed quantum cascade lasers (QCL): Establishing a new approach to non invasive glucose measurement

(2011) Miguel Pleitez et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Developing a kidney and urinary pathway knowledge base

(2011) Simon Jupp et al.   Journal of Biomedical Semantics

Investigation of the Ovarian and Prostate Cancer Peptidome for Candidate Early Detection Markers Using a Novel Nanoparticle Biomarker Capture Technology

(2010) Claudia Fredolini et al.   AAPS Journal

The use of hydrogel microparticles to sequester and concentrate bacterial antigens in a urine test for Lyme disease

(2010) Temple A. Douglas et al.   BIOMATERIALS

International Efforts to Develop Biospecimen Best Practices

(2010) J. B. Vaught et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Synthesis and characterization of hydrogel particles containing Cibacron Blue F3G-A

(2010) Alexis Patanarut et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Nanoparticle Technology: Addressing the Fundamental Roadblocks to Protein Biomarker Discovery

(2010) A. Luchini et al.   CURRENT MOLECULAR MEDICINE

Quantitative Analysis of the Intra- and Inter-Individual Variability of the Normal Urinary Proteome

(2010) Nagarjuna Nagaraj et al.   JOURNAL OF PROTEOME RESEARCH

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

(2010) David M. Good et al.   MOLECULAR & CELLULAR PROTEOMICS

Translating cancer research into targeted therapeutics

(2010) J. S. de Bono et al.   NATURE

Comprehensive human urine standards for comparability and standardization in clinical proteome analysis

(2010) Harald Mischak et al.   Proteomics Clinical Applications

A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine

(2010) Qing-Run Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

(2010) H. Mischak et al.   Science Translational Medicine

Identification of a bladder cancer-specific ligand using a combinatorial chemistry approach

(2010) Hongyong Zhang et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases

(2010) Daniel F. Gudbjartsson et al.   PLoS Genetics

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

(2010) Sandosh Padmanabhan et al.   PLoS Genetics

Discovery and Validation of Urine Markers of Acute Pediatric Appendicitis Using High-Accuracy Mass Spectrometry

(2009) Alex Kentsis et al.   ANNALS OF EMERGENCY MEDICINE

Serum free light chain analysis may miss monoclonal light chains that urine immunofixation electrophoreses would detect

(2009) Saad P. Shaheen et al.   CLINICA CHIMICA ACTA

Nanoparticle technology: amplifying the effective sensitivity of biomarker detection to create a urine test for hGH

(2009) Claudia Fredolini et al.   Drug Testing and Analysis

Combinatorial peptide ligand libraries for urine proteome analysis: Investigation of different elution systems

(2009) Giovanni Candiano et al.   ELECTROPHORESIS

Multiple loci associated with indices of renal function and chronic kidney disease

(2009) Anna Köttgen et al.   NATURE GENETICS

An Attempt to Understand Kidney's Protein Handling Function by Comparing Plasma and Urine Proteomes

(2009) Lulu Jia et al.   PLoS One

Urine proteomics for profiling of human disease using high accuracy mass spectrometry

(2009) Alex Kentsis et al.   Proteomics Clinical Applications

Hexapeptide combinatorial ligand libraries: the march for the detection of the low-abundance proteome continues

(2008) Egisto Boschetti et al.   BIOTECHNIQUES

The Human Protein Atlas-a tool for pathology

(2008) F Pontén et al.   JOURNAL OF PATHOLOGY

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

(2008) P. A. Gonzales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Genecentric Human Protein Atlas for Expression Profiles Based on Antibodies

(2008) Lisa Berglund et al.   MOLECULAR & CELLULAR PROTEOMICS

Urine in Clinical Proteomics

(2008) Stéphane Decramer et al.   MOLECULAR & CELLULAR PROTEOMICS

Selected reaction monitoring for quantitative proteomics: a tutorial

(2008) Vinzenz Lange et al.   Molecular Systems Biology

Concentration and preservation of very low abundance biomarkers in urine, such as human growth hormone (hGH), by Cibacron Blue F3G-A loaded hydrogel particles

(2008) Claudia Fredolini et al.   Nano Research

Sys-BodyFluid: a systematical database for human body fluid proteome research

(2008) S.-J. Li et al.   NUCLEIC ACIDS RESEARCH

Towards Standard Protocols and Guidelines for Urine Proteomics: A Report on the Human Kidney and Urine Proteome Project (HKUPP) Symposium and Workshop 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA

(2008) Tadashi Yamamoto et al.   PROTEOMICS

Discovery and validation of urinary biomarkers for prostate cancer

(2008) Dan Theodorescu et al.   Proteomics Clinical Applications

Smart Hydrogel Particles:  Biomarker Harvesting:  One-Step Affinity Purification, Size Exclusion, and Protection against Degradation

(2007) Alessandra Luchini et al.   NANO LETTERS