Escherichia coli Nissle 1917 secondary metabolism: aryl polyene biosynthesis and phosphopantetheinyl transferase crosstalk

Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation

(2021) Isabel Johnston et al.   npj Biofilms and Microbiomes

The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli

(2020) Clémence Massip et al.   MICROBES AND INFECTION

Chemical structure, biological roles, biosynthesis and regulation of the yellow xanthomonadin pigments in the phytopathogen Xanthomonas

(2020) YA-WEN HE et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

(2020) Cayetano Pleguezuelos-Manzano et al.   NATURE

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

(2020) Paulina J. Dziubańska-Kusibab et al.   NATURE MEDICINE

The Genotoxin Colibactin Shapes Gut Microbiota in Mice

(2020) Sophie Tronnet et al.   mSphere

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

(2019) Elaine Ballinger et al.   SCIENCE

An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments

(2019) Gina Luisa Carina Grammbitter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular basis for interactions between an acyl carrier protein and a ketosynthase

(2019) Jacob C. Milligan et al.   Nature Chemical Biology

Structure elucidation of colibactin and its DNA cross-links

(2019) Mengzhao Xue et al.   SCIENCE

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

(2019) Clémence Massip et al.   PLoS Pathogens

Distribution and functional analysis of the phosphopantetheinyl transferase superfamily inActinomycetalesmicroorganisms

(2018) Jeong Ho Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combination of docking and cheminformatics approaches for the identification of inhibitors against 4′ phosphopantetheinyl transferase of Mycobacterium tuberculosis

(2018) Akshay Rohilla et al.   RSC Advances

Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice

(2017) Alexander G. Bobrov et al.   Metallomics

Copper import in Escherichia coli by the yersiniabactin metallophore system

(2017) Eun-Ik Koh et al.   Nature Chemical Biology

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity

(2017) Anna Johns et al.   mBio

Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of Escherichia coli infection

(2017) Bing-Xiu Guo et al.   Oncotarget

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation

(2017) Jan-Ulrik Dahl et al.   Nature Microbiology

Cyanobacterial Sfp-type phosphopantetheinyl transferases functionalize carrier proteins of diverse biosynthetic pathways

(2017) Guang Yang et al.   Scientific Reports

Antibiotic Activity of Escherichia coli against Multiresistant Staphylococcus aureus

(2016) T. Faïs et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aryl Polyenes, a Highly Abundant Class of Bacterial Natural Products, Are Functionally Related to Antioxidative Carotenoids

(2016) Tim A. Schöner et al.   CHEMBIOCHEM

Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids

(2016) Joris Beld et al.   Molecular BioSystems

Characterization of Discrete Phosphopantetheinyl Transferases in Streptomyces tsukubaensis L19 Unveils a Complicate Phosphopantetheinylation Network

(2016) Yue-Yue Wang et al.   Scientific Reports

Biosynthesis and function of bacterial dialkylresorcinol compounds

(2015) Tim A. Schöner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Escherichia coli EDL933 Requires Gluconeogenic Nutrients To Successfully Colonize the Intestines of Streptomycin-Treated Mice Precolonized with E. coli Nissle 1917

(2015) Silvia A. C. Schinner et al.   INFECTION AND IMMUNITY

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Metal selectivity by the virulence-associated yersiniabactin metallophore system

(2015) Eun-Ik Koh et al.   Metallomics

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering

(2015) Joris Beld et al.   Molecular BioSystems

Colibactin: understanding an elusive gut bacterial genotoxin

(2015) Emily P. Balskus   NATURAL PRODUCT REPORTS

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

(2015) Carolyn A. Brotherton et al.   ORGANIC LETTERS

Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut

(2015) Vishal Singh et al.   Nature Communications

Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways

(2014) Philipp Engel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Crystal Structure of a PCP/Sfp Complex Reveals the Structural Basis for Carrier Protein Posttranslational Modification

(2014) Peter Tufar et al.   CHEMISTRY & BIOLOGY

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

(2014) Maria I. Vizcaino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and Biosynthesis of a Novel Xanthomonadin-Dialkylresorcinol-Hybrid from Azoarcus sp. BH72

(2014) Tim A. Schöner et al.   PLoS One

A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

(2014) Marnix H. Medema et al.   PLoS Computational Biology

Initiation of the flexirubin biosynthesis inChitinophaga pinensis

(2014) Tim A. Schöner et al.   Microbial Biotechnology

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

(2013) Marnix H. Medema et al.   MOLECULAR BIOLOGY AND EVOLUTION

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

(2013) Joris Beld et al.   NATURAL PRODUCT REPORTS

Nutritional Basis for Colonization Resistance by Human Commensal Escherichia coli Strains HS and Nissle 1917 against E. coli O157:H7 in the Mouse Intestine

(2013) Rosalie Maltby et al.   PLoS One

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli

(2013) Patricia Martin et al.   PLoS Pathogens

The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways

(2012) Lian Zhou et al.   MOLECULAR MICROBIOLOGY

IBD—what role do Proteobacteria play?

(2012) Indrani Mukhopadhya et al.   Nature Reviews Gastroenterology & Hepatology

Acyl carrier protein structural classification and normal mode analysis

(2012) David C. Cantu et al.   PROTEIN SCIENCE

The ClermontEscherichia coliphylo-typing method revisited: improvement of specificity and detection of new phylo-groups

(2012) Olivier Clermont et al.   Environmental Microbiology Reports

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

(2011) Nabil-Fareed Alikhan et al.   BMC GENOMICS

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Isolation and Characterization of Two Members of the Siderophore-Microcin Family, Microcins M and H47

(2009) G. Vassiliadis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The long-overlooked enzymology of a nonribosomal peptide synthetase-independent pathway for virulence-conferring siderophore biosynthesis

(2009) Daniel Oves-Costales et al.   CHEMICAL COMMUNICATIONS

Characterization of cellulose production inEscherichia coliNissle 1917 and its biological consequences

(2009) Cláudia Monteiro et al.   ENVIRONMENTAL MICROBIOLOGY

Genetic Interaction Between the Escherichia coli AcpT Phosphopantetheinyl Transferase and the YejM Inner Membrane Protein

(2008) N. R. De Lay et al.   GENETICS