Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines

The role of the multifunctional antimicrobial peptide melittin in gene delivery

(2021) Bilal Ahamad Paray et al.   DRUG DISCOVERY TODAY

Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo

(2021) Mahmoud A. Younis et al.   JOURNAL OF CONTROLLED RELEASE

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

(2021) Joshua J. Rennick et al.   Nature Nanotechnology

pH-Responsive Amphiphilic Carboxylate Polymers: Design and Potential for Endosomal Escape

(2021) Shiqi Wang   Frontiers in Chemistry

Endosomolytic and Tumor-Penetrating Mesoporous Silica Nanoparticles for siRNA/miRNA Combination Cancer Therapy

(2020) Yazhe Wang et al.   ACS Applied Materials & Interfaces

Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi

(2020) Tsogzolmaa Ganbold et al.   ACS Applied Materials & Interfaces

Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Vivo in Real-Time and at Ultrastructural Resolution

(2020) Yuya Hayashi et al.   ACS Nano

Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate paste

(2020) Taichi Tenkumo et al.   Acta Biomaterialia

A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes

(2020) Srinivas Ramishetti et al.   ADVANCED MATERIALS

Givosiran: First Approval

(2020) Lesley J. Scott   DRUGS

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

(2020) Juan C. Fraire et al.   JOURNAL OF CONTROLLED RELEASE

AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

(2020) Helena Costa Verdera et al.   MOLECULAR THERAPY

Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury

(2020) Chenglong Ge et al.   NANO LETTERS

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

(2020) Alyssa M. Flores et al.   Nature Nanotechnology

Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery

(2020) Wei Wei et al.   ACS Applied Materials & Interfaces

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

(2020) Thijs Van de Vyver et al.   ACS Nano

Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities

(2020) Jinfang Zhang et al.   ACS Nano

Optimization of antisense-mediated exon skipping for Duchenne muscular dystrophy

(2020) Kasia Dzierlega et al.   GENE THERAPY

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

(2020) A.C. Marques et al.   JOURNAL OF CONTROLLED RELEASE

Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules

(2020) Naoki Tamemoto et al.   MOLECULAR PHARMACEUTICS

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Insights from nanomedicine into chloroquine efficacy against COVID-19

(2020) Tony Y. Hu et al.   Nature Nanotechnology

Imaging small molecule-induced endosomal escape of siRNA

(2020) Hampus Du Rietz et al.   Nature Communications

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery

(2020) Niko Kimura et al.   ACS Applied Materials & Interfaces

Lipid nanoparticles for nucleic acid delivery: Current perspectives

(2020) Eleni Samaridou et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid nanoparticle technology for therapeutic gene regulation in the liver

(2020) Dominik Witzigmann et al.   ADVANCED DRUG DELIVERY REVIEWS

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Discovering and validating cancer genetic dependencies: approaches and pitfalls

(2020) Ann Lin et al.   NATURE REVIEWS GENETICS

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

(2020) Wei Tao et al.   Science Translational Medicine

Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

(2020) Gabriela Arias-Alpizar et al.   Nature Communications

Author Correction: Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Tandem‐Mass‐Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition

(2020) Yunzhan Li et al.   Advanced Science

Antisense Oligonucleotides: An Emerging Area in Drug Discovery and Development

(2020) Karishma Dhuri et al.   Journal of Clinical Medicine

Peptides as a material platform for gene delivery: Emerging concepts and converging technologies

(2020) Morgan Urello et al.   Acta Biomaterialia

Charge reversible hyaluronic acid-modified dendrimer-based nanoparticles for siMDR-1 and doxorubicin co-delivery

(2020) Xin Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection

(2020) Gustavo Lou et al.   JOURNAL OF CONTROLLED RELEASE

Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy

(2020) Nour Shobaki et al.   JOURNAL OF CONTROLLED RELEASE

siRNA based drug design, quality, delivery and clinical translation

(2020) Md Abdus Subhan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gene Therapy Based on Nucleic Acid Nanostructure

(2020) Xiaohui Wu et al.   Advanced Healthcare Materials

Bacteria‐Derived Nanoparticles: Multifunctional Containers for Diagnostic and Therapeutic Applications

(2020) Lin Liu et al.   Advanced Healthcare Materials

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

(2020) Marvin Krohn-Grimberghe et al.   Nature Biomedical Engineering

A quantitative view on multivalent nanomedicine targeting

(2020) Laura Woythe et al.   ADVANCED DRUG DELIVERY REVIEWS

Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer

(2019) Jiangsheng Xu et al.   Nature Nanotechnology

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

(2019) Gulsah Erel-Akbaba et al.   ACS Nano

Delivery of microRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux In Vitro and In Vivo

(2019) My-Anh Nguyen et al.   ACS Nano

Strategies, design, and chemistry in siRNA delivery systems

(2019) Yizhou Dong et al.   ADVANCED DRUG DELIVERY REVIEWS

Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice

(2019) Changmai Chen et al.   BIOCONJUGATE CHEMISTRY

Efficacy and Safety of Mipomersen: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

(2019) Federica Fogacci et al.   DRUGS

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cancer-Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery

(2019) Hannah J. Vaughan et al.   ADVANCED MATERIALS

Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide‐Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA

(2019) Byungji Kim et al.   ADVANCED MATERIALS

Natural Polysaccharides for siRNA Delivery: Nanocarriers Based on Chitosan, Hyaluronic Acid, and Their Derivatives

(2019) Inés Serrano-Sevilla et al.   MOLECULES

Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery

(2019) Wanyi Tai   MOLECULES

A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics

(2019) Saowanee Wannasarit et al.   ADVANCED FUNCTIONAL MATERIALS

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands

(2019) Melissa P. Lokugamage et al.   ADVANCED MATERIALS

Polymeric Vector-Mediated Targeted Delivery of Anti-PAK1 siRNA to Macrophages for Efficient Atherosclerosis Treatment

(2019) Teng Wu et al.   ACS Biomaterials-Science & Engineering

Targeted Delivery of siRNA Lipoplexes to Cancer Cells Using Macrophage Transient Horizontal Gene Transfer

(2019) Elizabeth C. Wayne et al.   Advanced Science

Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis

(2019) Hang Yu et al.   BIOMATERIALS

Leukocyte-specific siRNA delivery revealing IRF8 as a potential anti-inflammatory target

(2019) Nuphar Veiga et al.   JOURNAL OF CONTROLLED RELEASE

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

(2019) Brian C. Evans et al.   Nature Communications

The chemistry and applications of RNA 2′-OH acylation

(2019) Willem A. Velema et al.   Nature Reviews Chemistry

A Light-Triggerable Nanoparticle Library for the Controlled Release of Non-Coding RNAs

(2019) Josephine Blersch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

(2019) Rafal Bartoszewski et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Insight into the siRNA transmembrane delivery—From cholesterol conjugating to tagging

(2019) Yan Zheng et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Calcium–MicroRNA Complex-Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells

(2018) Wen Song et al.   ACS Applied Materials & Interfaces

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

(2018) Frederick Campbell et al.   ACS Nano

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

(2018) Lotte M. P. Vermeulen et al.   ACS Nano

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

(2018) Wei Li et al.   ADVANCED MATERIALS

Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity

(2018) Ditlev Birch et al.   BIOCHEMICAL JOURNAL

Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation

(2018) Yang Liu et al.   BIOMATERIALS

Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics

(2018) Jianliang Shen et al.   CHEMICAL SOCIETY REVIEWS

Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer

(2018) Ga Hee Kim et al.   DRUG DELIVERY

The proton sponge hypothesis: Fable or fact?

(2018) Lotte M.P. Vermeulen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells

(2018) Freya Joris et al.   JOURNAL OF CONTROLLED RELEASE

Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate

(2018) Abdulaziz M. Aldayel et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Delivery of Therapeutic siRNA with Nanoparticles Induces Apoptosis in Prostate Cancer Cells

(2018) Xupeng Mu et al.   Journal of Nanomaterials

Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing

(2018) Zhen Zhang et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Cationic Polymeric Nanoparticle Delivering CCR2 siRNA to Inflammatory Monocytes for Tumor Microenvironment Modification and Cancer Therapy

(2018) Song Shen et al.   MOLECULAR PHARMACEUTICS

Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA

(2018) Rebecca L. Ball et al.   NANO LETTERS

A modular platform for targeted RNAi therapeutics

(2018) Ranit Kedmi et al.   Nature Nanotechnology

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

(2018) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

(2018) Vikash Reebye et al.   ONCOGENE

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient cell delivery mediated by lipid-specific endosomal escape of supercharged branched peptides

(2018) Dakota J. Brock et al.   TRAFFIC

Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus

(2018) Byungji Kim et al.   Nature Communications

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

(2018) Do-Hyun Kim et al.   Nature Communications

Cellular conditions of weakly chelated magnesium ions strongly promote RNA stability and catalysis

(2018) Ryota Yamagami et al.   Nature Communications

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs

(2018) Ludger Johannes et al.   Nucleic Acid Therapeutics

Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation

(2018) Zhihang Chen et al.   Theranostics

Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates

(2018) Santiago Grijalvo et al.   Genes

Nanoscale delivery systems for cancer immunotherapy

(2018) Zejun Wang et al.   Materials Horizons

A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

(2018) Wenjun Li et al.   Materials Horizons

Tumor-specific disintegratable nanohybrids containing ultrasmall inorganic nanoparticles: from design and improved properties to cancer applications

(2018) Yun Wang et al.   Materials Horizons

Polymer Brushes: Efficient Synthesis and Applications

(2018) Chun Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells

(2018) Yudong Song et al.   BIOMATERIALS

Inotersen: First Global Approval

(2018) Susan J. Keam   DRUGS

Nanoparticle Delivery of miRNA-21 Mimic to Cardiac Macrophages Improves Myocardial Remodeling after Myocardial Infarction

(2018) Tzlil Bejerano et al.   NANO LETTERS

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

The great escape: how cationic polyplexes overcome the endosomal barrier

(2018) Tanja Bus et al.   Journal of Materials Chemistry B

Super-resolution Imaging of Proton Sponge-Triggered Rupture of Endosomes and Cytosolic Release of Small Interfering RNA

(2018) Marcin Wojnilowicz et al.   ACS Nano

Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers

(2018) Haonan Xing et al.   Acta Biomaterialia

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

(2018) Nuphar Veiga et al.   Nature Communications

A Robust Nanoparticle Platform for RNA Interference in Macrophages to Suppress Tumor Cell Migration

(2018) Shi Liang et al.   Frontiers in Pharmacology

Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

(2018) C. Siewert et al.   BIOMATERIALS

Antiviral activity of cationic amphiphilic drugs

(2017) Cristiano Salata et al.   Expert Review of Anti-Infective Therapy

Using siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation in psoriasis

(2017) Houshang Nemati et al.   JOURNAL OF CONTROLLED RELEASE

pH-Triggered, Macromolecule-Sized Poration of Lipid Bilayers by Synthetically Evolved Peptides

(2017) Gregory Wiedman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?

(2017) Rituparna Acharya et al.   Materials Science & Engineering C-Materials for Biological Applications

Preclinical Mammalian Safety Studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA)

(2017) Michael J. Wagner et al.   MOLECULAR CANCER THERAPEUTICS

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

(2017) Yue Lu et al.   NANO LETTERS

Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

(2017) W. Viricel et al.   Nanoscale

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

(2017) Misao Akishiba et al.   Nature Chemistry

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy

(2017) Hongbo Zhang et al.   Advanced Healthcare Materials

Silica-based multifunctional nanodelivery systems toward regenerative medicine

(2017) Roman A. Perez et al.   Materials Horizons

Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

(2017) H. W. Ooi et al.   Materials Horizons

Recent developments in self-oscillating polymeric systems as smart materials: from polymers to bulk hydrogels

(2017) Youn Soo Kim et al.   Materials Horizons

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?

(2017) Zhongji Meng et al.   Frontiers in Immunology

Polymer–Nucleic Acid Interactions

(2017) Zhuang-lin Shen et al.   Topics in Current Chemistry

Role of Cell Membrane–Vector Interactions in Successful Gene Delivery

(2016) Sriram Vaidyanathan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics

(2016) Soo Hyeon Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain

(2016) Jinyoung Kang et al.   ADVANCED MATERIALS

Gene regulation with carbon-based siRNA conjugates for cancer therapy

(2016) Lingmin Zhang et al.   BIOMATERIALS

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

(2016) Kejin Zhou et al.   CHEMICAL COMMUNICATIONS

Utility of the 2-Nitrobenzenesulfonamide Group as a Chemical Linker for Enhanced Extracellular Stability and Cytosolic Cleavage in siRNA-Conjugated Polymer Systems

(2016) Chih Hao Huang et al.   ChemMedChem

Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy

(2016) Jogender Tushir-Singh   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

An l- to d-Amino Acid Conversion in an Endosomolytic Analog of the Cell-penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape

(2016) Kristina Najjar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tailoring Lipid and Polymeric Nanoparticles as siRNA Carriers towards the Blood-Brain Barrier – from Targeting to Safe Administration

(2016) Maria João Gomes et al.   Journal of Neuroimmune Pharmacology

Structure-Function Correlations of Poly(Amido Amine)s for Gene Delivery

(2016) Yanping Sun et al.   MACROMOLECULAR BIOSCIENCE

Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System

(2016) Xiaona Jing et al.   MOLECULAR PHARMACEUTICS

Cytosolic Delivery of Nanolabels Prevents Their Asymmetric Inheritance and Enables Extended Quantitative in Vivo Cell Imaging

(2016) Ranhua Xiong et al.   NANO LETTERS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Visualization of self-delivering hydrophobically modified siRNA cellular internalization

(2016) Socheata Ly et al.   NUCLEIC ACIDS RESEARCH

Quantum dots–DNA bioconjugates: synthesis to applications

(2016) Anusuya Banerjee et al.   Interface Focus

Biomaterials in siRNA Delivery: A Comprehensive Review

(2016) William Ho et al.   Advanced Healthcare Materials

Defibrotide (Defitelio): A New Addition to the Stockpile of Food and Drug Administration-approved Oligonucleotide Drugs

(2016) Cy Stein et al.   Molecular Therapy-Nucleic Acids

Distribution of Systemically Administered Nanoparticles Reveals a Size-Dependent Effect Immediately following Cardiac Ischaemia-Reperfusion Injury

(2016) David J. Lundy et al.   Scientific Reports

Polysaccharide Nanoparticles for Efficient siRNA Targeting in Cancer Cells by Supramolecular pKa Shift

(2016) Ying-Ming Zhang et al.   Scientific Reports

Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery

(2015) Lu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance

(2015) Steven K. Jones et al.   BIOMACROMOLECULES

Calcium–siRNA nanocomplexes: What reversibility is all about

(2015) Emil Ruvinov et al.   JOURNAL OF CONTROLLED RELEASE

Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles

(2015) Lei Wang et al.   JOURNAL OF DRUG TARGETING

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

(2015) Alex K. K. Leung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Reversible Activation of a Cell-Penetrating Peptide in a Membrane Environment

(2015) Denise K. Schach et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells

(2015) Jijin Gu et al.   MOLECULAR PHARMACEUTICS

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Degradable vinyl polymers for biomedical applications

(2015) Vianney Delplace et al.   Nature Chemistry

Identification of siRNA delivery enhancers by a chemical library screen

(2015) Jerome Gilleron et al.   NUCLEIC ACIDS RESEARCH

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

(2015) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Mechanism Matters: A Taxonomy of Cell Penetrating Peptides

(2015) W. Berkeley Kauffman et al.   TRENDS IN BIOCHEMICAL SCIENCES

The influence of polymer architecture on in vitro pDNA transfection

(2015) Alexandra C. Rinkenauer et al.   Journal of Materials Chemistry B

Universal polymer coatings and their representative biomedical applications

(2015) Qiang Wei et al.   Materials Horizons

Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery

(2015) Zhiqin Chu et al.   Scientific Reports

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Rab proteins: The key regulators of intracellular vesicle transport

(2014) Tanmay Bhuin et al.   EXPERIMENTAL CELL RESEARCH

Cellular Uptake of Substrate-Initiated Cell-Penetrating Poly(disulfide)s

(2014) Giulio Gasparini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular Plasmonic Nanocarriers for Efficient and Targeted Delivery of Cancer-Therapeutic siRNA

(2014) Xiao Huang et al.   NANO LETTERS

Imaging macrophages with nanoparticles

(2014) Ralph Weissleder et al.   NATURE MATERIALS

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

(2014) Trinna L. Cuellar et al.   NUCLEIC ACIDS RESEARCH

Lipid compartmentalization in the endosome system

(2014) Françoise Hullin-Matsuda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Nanoparticle-Mediated Systemic Delivery of siRNA for Treatment of Cancers and Viral Infections

(2014) Mohamed Shehata Draz et al.   Theranostics

Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds

(2014) Shu-ichi Nakano et al.   FEBS Open Bio

Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis

(2013) Zia ur Rehman et al.   ACS Nano

Polysaccharide-based nucleic acid nanoformulations

(2013) Koen Raemdonck et al.   ADVANCED DRUG DELIVERY REVIEWS

Smart ligand: Aptamer-mediated targeted delivery of chemotherapeutic drugs and siRNA for cancer therapy

(2013) Xin Li et al.   JOURNAL OF CONTROLLED RELEASE

Substrate-Initiated Synthesis of Cell-Penetrating Poly(disulfide)s

(2013) Eun-Kyoung Bang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adsorption and Release of siRNA from Porous Silica

(2013) Jeremy L. Steinbacher et al.   LANGMUIR

Stabilization of Distearoylphosphatidylcholine Lamellar Phases in Propylene Glycol Using Cholesterol

(2013) Richard D. Harvey et al.   MOLECULAR PHARMACEUTICS

Endocytosis of Gene Delivery Vectors: From Clathrin-dependent to Lipid Raft-mediated Endocytosis

(2013) Ayman El-Sayed et al.   MOLECULAR THERAPY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

(2013) C. A. Alabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supramolecular host–guest polymeric materials for biomedical applications

(2013) Xian Jun Loh   Materials Horizons

Achieving efficient RNAi therapy: progress and challenges

(2013) Kun Gao et al.   Acta Pharmaceutica Sinica B

Chloride in Vesicular Trafficking and Function

(2012) Tobias Stauber et al.   Annual Review of Physiology

SnapShot: Mammalian Rab Proteins in Endocytic Trafficking

(2012) Thierry Galvez et al.   CELL

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

(2012) Alex K. K. Leung et al.   Journal of Physical Chemistry C

Involvement of Ca2+ and ATP in Enhanced Gene Delivery by Bubble Liposomes and Ultrasound Exposure

(2012) Daiki Omata et al.   MOLECULAR PHARMACEUTICS

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Subtle Changes to Polymer Structure and Degradation Mechanism Enable Highly Effective Nanoparticles for siRNA and DNA Delivery to Human Brain Cancer

(2012) Stephany Y. Tzeng et al.   Advanced Healthcare Materials

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Biophysical properties of chitosan/siRNA polyplexes: Profiling the polymer/siRNA interactions and bioactivity

(2011) Pascale Holzerny et al.   JOURNAL OF CONTROLLED RELEASE

General Description of the Adsorption of Proteins at Their Iso-electric Point in Nanoporous Materials

(2011) Lung-Ching Sang et al.   LANGMUIR

Bubble Liposomes and Ultrasound Promoted Endosomal Escape of TAT-PEG Liposomes as Gene Delivery Carriers

(2011) Daiki Omata et al.   MOLECULAR PHARMACEUTICS

Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization

(2011) J. T. Roland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Storage of environmental samples for guaranteeing nucleic acid yields for molecular microbiological studies

(2010) Antti Juhani Rissanen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties

(2010) Jesús Prades et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: Quality by design optimization and characterization

(2010) Dongmei Cun et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

(2010) Sylvie Boutin et al.   HUMAN GENE THERAPY

Comparison of chitosan/siRNA and trimethylchitosan/siRNA complexes behaviour in vitro

(2010) V. Dehousse et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

siRNA vs. shRNA: Similarities and differences

(2009) Donald D. Rao et al.   ADVANCED DRUG DELIVERY REVIEWS

Chitosan-based formulations for delivery of DNA and siRNA

(2009) Shirui Mao et al.   ADVANCED DRUG DELIVERY REVIEWS

RNAi-based therapeutics-current status, challenges and prospects

(2009) Katrin Tiemann et al.   EMBO Molecular Medicine

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery

(2009) Jun Li et al.   JOURNAL OF CONTROLLED RELEASE

Elucidating the Encapsulation of Short Interfering RNA in PEGylated Cationic Liposomes

(2009) Kevin Buyens et al.   LANGMUIR

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

(2009) Aly A Khan et al.   NATURE BIOTECHNOLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Characterizing hydrophobicity of interfaces by using cavity formation, solute binding, and water correlations

(2009) R. Godawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for targeted nonviral delivery of siRNAs in vivo

(2009) Sang-Soo Kim et al.   TRENDS IN MOLECULAR MEDICINE

Gene expression silencing with ‘specific’ small interfering RNA goes beyond specificity - a study of key parameters to take into account in the onset of small interfering RNA off-target effects

(2008) Sébastien Vankoningsloo et al.   FEBS Journal

Breathing Life into Polycations:  Functionalization with pH-Responsive Endosomolytic Peptides and Polyethylene Glycol Enables siRNA Delivery

(2008) Martin Meyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nonviral Methods for siRNA Delivery

(2008) Kun Gao et al.   MOLECULAR PHARMACEUTICS