CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment

Identification of a novel tumor angiogenesis inhibitor targeting Shh/Gli1 signaling pathway in Non-small cell lung cancer

(2020) Xueping Lei et al.   Cell Death & Disease

Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

(2020) Joon Won Yoon et al.   BMC CANCER

Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes

(2019) Shabana Amanda Ali et al.   PLoS One

GLI inhibitors overcome Erlotinib resistance in human pancreatic cancer cells by modulating E-cadherin

(2019) Amir Ghanbari et al.   JOURNAL OF CHEMOTHERAPY

Regulation of GLI1 by cis DNA elements and epigenetic marks

(2019) Robert Taylor et al.   DNA REPAIR

Inhibition of the Hedgehog pathway in lung cancer

(2019) A. Dimou et al.   LUNG CANCER

“Application of Small Molecule CHIR99021 Leads to the Loss of Hemangioblast Progenitor and Increased Hematopoiesis of Human Pluripotent Stem Cells”

(2018) Yekaterina Galat et al.   EXPERIMENTAL HEMATOLOGY

GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis–van Creveld syndrome

(2017) Adrian Palencia-Campos et al.   HUMAN MOLECULAR GENETICS

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

(2017) A Po et al.   ONCOGENE

Gli1 identifies osteogenic progenitors for bone formation and fracture repair

(2017) Yu Shi et al.   Nature Communications

Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential

(2017) Yekaterina Galat et al.   Stem Cell Research & Therapy

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

(2016) Q Chen et al.   CELL DEATH AND DIFFERENTIATION

Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

(2016) Vasiliy Galat et al.   STEM CELLS AND DEVELOPMENT

Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation

(2016) Xue Yuan et al.   Nature Communications

p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9

(2015) Joon Won Yoon et al.   DNA REPAIR

Sonic Hedgehog–GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2

(2015) Xuanfu Xu et al.   PANCREAS

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

(2015) Richard L. Carpenter et al.   Oncotarget

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

(2015) Akwasi Agyeman et al.   Oncotarget

Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

(2014) V. T. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

Gli1 Haploinsufficiency Leads to Decreased Bone Mass with an Uncoupling of Bone Metabolism in Adult Mice

(2014) Yoshiaki Kitaura et al.   PLoS One

Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling

(2014) Xiaojun Lian et al.   Stem Cell Reports

Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma

(2013) Joon Won Yoon et al.   MOLECULAR CANCER RESEARCH

Gli1 Protein Participates in Hedgehog-mediated Specification of Osteoblast Lineage during Endochondral Ossification

(2012) Hironori Hojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Lysosomal Transmembrane Protein LAPTM4B Promotes Autophagy and Tolerance to Metabolic Stress in Cancer Cells

(2011) Y. Li et al.   CANCER RESEARCH

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells

(2011) Kyung-Dal Choi et al.   Nature Protocols

Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors

(2010) A. Merchant et al.   BLOOD

Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development

(2010) Ekati Drakopoulou et al.   CELL CYCLE

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells

(2010) Mark Denham et al.   STEM CELLS

Transcription factors and neural stem cell self-renewal, growth and differentiation

(2010) Sohail Ahmed et al.   Cell Adhesion & Migration

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Sonic hedgehog signaling and the expression of its components in human embryonic stem cells

(2009) Selena Meiyun Wu et al.   Stem Cell Research

Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes

(2008) Joon Won Yoon et al.   INTERNATIONAL JOURNAL OF CANCER

Sonic Hedgehog-responsive Genes in the Fetal Prostate

(2008) Min Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gli1 Induces G2/M Arrest and Apoptosis in Hippocampal but Not Tumor-Derived Neural Stem Cells

(2008) Katherine E. Galvin et al.   STEM CELLS