Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians

(2020) Meng Lin et al.   HUMAN MOLECULAR GENETICS

A simple new approach to variable selection in regression, with application to genetic fine mapping

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Comparing local ancestry inference models in populations of two- and three-way admixture

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Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda

(2019) Anne Stevenson et al.   BMJ Open

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

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(2019) Line Skotte et al.   GENETIC EPIDEMIOLOGY

Genetics of Common, Complex Coronary Artery Disease

(2019) Kiran Musunuru et al.   CELL

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

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(2019) Michelle Daya et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

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Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE

(2019) Stephanie A. Bien et al.   Annual Review of Genomics and Human Genetics

Self‐Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsy

(2019) William E. Grizzle et al.   Cancer Medicine

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Comparative genetic architectures of schizophrenia in East Asian and European populations

(2019) Max Lam et al.   NATURE GENETICS

Characterizing rare and low-frequency height-associated variants in the Japanese population

(2019) Masato Akiyama et al.   Nature Communications

The transferability of lipid loci across African, Asian and European cohorts

(2019) Karoline Kuchenbaecker et al.   Nature Communications

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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A comprehensive survey of models for dissecting local ancestry deconvolution in human genome

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Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

From genome-wide associations to candidate causal variants by statistical fine-mapping

(2018) Daniel J. Schaid et al.   NATURE REVIEWS GENETICS

Comparison of phasing strategies for whole human genomes

(2018) Yongwook Choi et al.   PLoS Genetics

No Evidence for Recent Selection at FOXP2 among Diverse Human Populations

(2018) Elizabeth Grace Atkinson et al.   CELL

An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos

(2018) Chris R. Gignoux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma

(2018) Melissa L. Spear et al.   PHARMACOGENOMICS JOURNAL

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

(2018) Pradeep Natarajan et al.   Nature Communications

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

(2018) Annah B. Wyss et al.   Nature Communications

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

(2018) Raymond K. Walters et al.   NATURE NEUROSCIENCE

Population structure in genetic studies: Confounding factors and mixed models

(2018) Jae Hoon Sul et al.   PLoS Genetics

Racial disparities in prostate cancer a molecular perspective

(2017) Arun Bhardwaj   Frontiers in Bioscience-Landmark

Properties of global- and local-ancestry adjustments in genetic association tests in admixed populations

(2017) Eden R. Martin et al.   GENETIC EPIDEMIOLOGY

Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways

(2017) Amnah Siddiqa et al.   GENOMICS

The United States Leads Other Nations In Differences By Income In Perceptions Of Health And Health Care

(2017) Joachim O. Hero et al.   HEALTH AFFAIRS

The genomic landscape of African populations in health and disease

(2017) Charles N. Rotimi et al.   HUMAN MOLECULAR GENETICS

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

(2017) Reedik Mägi et al.   HUMAN MOLECULAR GENETICS

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Trans -ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

(2017) Maren E. Cannon et al.   G3-Genes Genomes Genetics

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(2017) Athanase Benetos et al.   Circulation-Cardiovascular Genetics

The Surveillance, Epidemiology, and End Results (SEER) Program and Pathology

(2016) Máire A. Duggan et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

FINEMAP: efficient variable selection using summary data from genome-wide association studies

(2016) Christian Benner et al.   BIOINFORMATICS

Understanding associations among race, socioeconomic status, and health: Patterns and prospects.

(2016) David R. Williams et al.   HEALTH PSYCHOLOGY

Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set

(2016) Masahiro Kanai et al.   JOURNAL OF HUMAN GENETICS

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(2016) Alice B. Popejoy et al.   NATURE

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

(2016) Ren Zhang   Open Biology

Ancestry variation and footprints of natural selection along the genome in Latin American populations

(2016) Lian Deng et al.   Scientific Reports

Leveraging local ancestry to detect gene-gene interactions in genome-wide data

(2015) Hugues Aschard et al.   BMC GENETICS

Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes

(2015) Hodaka Yamada et al.   ENDOCRINE JOURNAL

A Generalized Sequential Bonferroni Procedure for GWAS in Admixed Populations Incorporating Admixture Mapping Information into Association Tests

(2015) Wenan Chen et al.   HUMAN HEREDITY

Strategies for fine-mapping complex traits

(2015) Sarah L. Spain et al.   HUMAN MOLECULAR GENETICS

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(2015) Richard A. Gibbs et al.   NATURE

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration

(2015) Mark W Logue et al.   NEUROPSYCHOPHARMACOLOGY

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci

(2015) Martijn van de Bunt et al.   PLoS Genetics

Variants for HDL-C, LDL-C, and Triglycerides Identified from Admixture Mapping and Fine-Mapping Analysis in African American FamiliesCLINICAL PERSPECTIVE

(2015) Priya B. Shetty et al.   Circulation-Cardiovascular Genetics

A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase

(2015) Zhiyao Fu et al.   Scientific Reports

Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients

(2014) Hao Hu et al.   DIABETES CARE

The Role of Local Ancestry Adjustment in Association Studies Using Admixed Populations

(2014) Jianqi Zhang et al.   GENETIC EPIDEMIOLOGY

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

(2014) Anubha Mahajan et al.   NATURE GENETICS

Enabling the genomic revolution in Africa

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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes

(2014) Daniel Espes et al.   International Journal of Endocrinology

Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity

(2014) Zhiyao Fu et al.   Scientific Reports

Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

(2014) Yun R Li et al.   Genome Medicine

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference

(2013) Brian K. Maples et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations

(2013) Marc A. Coram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation

(2013) Bogdan Pasaniuc et al.   BIOINFORMATICS

Improved ancestry inference using weights from external reference panels

(2013) Chia-Yen Chen et al.   BIOINFORMATICS

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population

(2013) E. R. Chimusa et al.   HUMAN MOLECULAR GENETICS

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

(2013) Christopher S. Carlson et al.   PLOS BIOLOGY

High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

(2013) Urko M. Marigorta et al.   PLoS Genetics

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

(2013) Ying Wu et al.   PLoS Genetics

Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women

(2012) Alex P. Reiner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

(2012) Ren Zhang   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers

(2012) Joseph Lachance et al.   CELL

Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping

(2012) Priya B. Shetty et al.   JOURNAL OF HYPERTENSION

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(2012) H. Robert Superko et al.   MEDICAL CLINICS OF NORTH AMERICA

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression

(2012) Jingyuan Fu et al.   PLoS Genetics

Genome-wide detection of natural selection in African Americans pre- and post-admixture

(2011) W. Jin et al.   GENOME RESEARCH

Consistency of genome-wide associations across major ancestral groups

(2011) Evangelia E. Ntzani et al.   HUMAN GENETICS

Recombination rates in admixed individuals identified by ancestry-based inference

(2011) Daniel Wegmann et al.   NATURE GENETICS

Demographic history and rare allele sharing among human populations

(2011) S. Gravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains

(2011) Christy L. Avery et al.   PLoS Genetics

Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium

(2011) Bogdan Pasaniuc et al.   PLoS Genetics

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

(2011) Serena Sanna et al.   PLoS Genetics

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

(2011) Guillaume Lettre et al.   PLoS Genetics

Leveraging Genetic Variability across Populations for the Identification of Causal Variants

(2010) Noah Zaitlen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LocusZoom: regional visualization of genome-wide association scan results

(2010) R. J. Pruim et al.   BIOINFORMATICS

Joint testing of genotype and ancestry association in admixed families

(2010) Hua Tang et al.   GENETIC EPIDEMIOLOGY

Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups

(2010) Kevin M. Waters et al.   PLoS Genetics

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

(2009) Philippa J. Talmud et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fast model-based estimation of ancestry in unrelated individuals

(2009) D. H. Alexander et al.   GENOME RESEARCH

Genome-wide association study of bipolar disorder in European American and African American individuals

(2009) E N Smith et al.   MOLECULAR PSYCHIATRY

The Genetic Structure and History of Africans and African Americans

(2009) S. A. Tishkoff et al.   SCIENCE

Global strategy for asthma management and prevention: GINA executive summary

(2008) E. D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

LDL-cholesterol concentrations: a genome-wide association study

(2008) Manjinder S Sandhu et al.   LANCET