G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex

(2020) Magdalena Kedra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations

(2020) Patrick Hansmann et al.   STRUCTURE

The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

(2020) Shu Yang et al.   DEVELOPMENTAL CELL

Mammalian stress granules and P bodies at a glance

(2020) Claire L. Riggs et al.   JOURNAL OF CELL SCIENCE

G3BP1 controls the senescence-associated secretome and its impact on cancer progression

(2020) Amr Omer et al.   Nature Communications

Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases

(2019) Kuang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

(2019) Aleksandra Siekierska et al.   Nature Communications

Impaired cortico-striatal excitatory transmission triggers epilepsy

(2019) Hiroyuki Miyamoto et al.   Nature Communications

Phosphorylation of G3BP1-S149 does not influence stress granule assembly

(2019) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

(2019) Mathias Bockwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

(2019) Ya-Cheng Liao et al.   CELL

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10

(2019) Sergei Anisimov et al.   Scientific Reports

Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome

(2019) Alexandre Brenet et al.   Cells

Modifying genetic epilepsies – Results from studies on tuberous sclerosis complex

(2019) Sergiusz Jozwiak et al.   NEUROPHARMACOLOGY

The mTOR-S6 kinase pathway promotes stress granule assembly

(2018) Aristeidis P. Sfakianos et al.   CELL DEATH AND DIFFERENTIATION

The Target of Rapamycin and Mechanisms of Cell Growth

(2018) Andrew Tee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy

(2018) E. Marsan et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas

(2018) Yong Wang et al.   Cell Death & Disease

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Rasputin a decade on and more promiscuous than ever? A review of G3BPs

(2018) Umber Alam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays

(2018) Tobias Gebäck et al.   BIOTECHNIQUES

The roles and mechanisms of G3BP1 in tumour promotion

(2018) Cong-Hui Zhang et al.   JOURNAL OF DRUG TARGETING

Differences between acute and chronic stress granules, and how these differences may impact function in human disease

(2018) Lucas C. Reineke et al.   BIOCHEMICAL PHARMACOLOGY

Can a Charged Surfactant Unfold an Uncharged Protein?

(2018) Casper Højgaard et al.   BIOPHYSICAL JOURNAL

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance

(2017) Yuri Bozzi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy

(2017) Borbála Hunyadi et al.   JOURNAL OF NEUROSCIENCE METHODS

TrackMate: An open and extensible platform for single-particle tracking

(2017) Jean-Yves Tinevez et al.   METHODS

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis

(2017) Chloë Scheldeman et al.   NEUROBIOLOGY OF DISEASE

Molecular neurobiology of mTOR

(2017) Katarzyna Switon et al.   NEUROSCIENCE

Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes

(2017) Lydie Debaize et al.   Molecular Cytogenetics

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

(2016) Jo Sourbron et al.   ACS Chemical Neuroscience

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex

(2016) Andrew R. Tee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lysosomal recruitment of TSC2 is a universal response to cellular stress

(2016) Constantinos Demetriades et al.   Nature Communications

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

(2015) Antje Thien et al.   DEVELOPMENTAL CELL

Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate

(2015) Jennifer Jasmin Schwarz et al.   MOLECULAR & CELLULAR PROTEOMICS

Transgenic Zebrafish Expressing mCherry in the Mitochondria of Dopaminergic Neurons

(2015) Sandra Noble et al.   Zebrafish

Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway

(2015) Hao Zhang et al.   Oncotarget

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

(2015) P. B. Crino   Cold Spring Harbor Perspectives in Medicine

mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?

(2015) David J. Kwiatkowski et al.   EBioMedicine

Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine

(2015) Yifan Zhang et al.   PLoS One

De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies

(2014) Silke Appenzeller et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

TBC1D7Mutations are Associated with Intellectual Disability, Macrocrania, Patellar Dislocation, and Celiac Disease

(2014) Ali Abdullah Alfaiz et al.   HUMAN MUTATION

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses

(2014) Lucas C. Reineke et al.   JOURNAL OF VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Stress granules are dispensable for mRNA stabilization during cellular stress

(2014) Nadine Bley et al.   NUCLEIC ACIDS RESEARCH

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

(2014) N. Wagle et al.   Cancer Discovery

Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts

(2014) Xiaoxue Yang et al.   PLoS Genetics

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

(2013) Kathrin Thedieck et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals

(2013) M. Jedrusik-Bode et al.   JOURNAL OF CELL SCIENCE

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly

(2013) José-Mario Capo-Chichi et al.   JOURNAL OF MEDICAL GENETICS

Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons

(2013) Sophie Martin et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast cancer cells

(2013) Sofia Winslow et al.   Molecular Cancer

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Whole-brain functional imaging at cellular resolution using light-sheet microscopy

(2013) Misha B Ahrens et al.   NATURE METHODS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Epilepsy in kcnj10 Morphant Zebrafish Assessed with a Novel Method for Long-Term EEG Recordings

(2013) Anselm A. Zdebik et al.   PLoS One

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

(2013) M. Weiler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

From Sequence and Forces to Structure, Function, and Evolution of Intrinsically Disordered Proteins

(2013) Julie D. Forman-Kay et al.   STRUCTURE

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function

(2013) Matthew O. Parker et al.   Frontiers in Neural Circuits

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplaitin-mediated cytotoxicity to colon carcinoma HCT116 cells

(2012) Hao Zhang et al.   CANCER SCIENCE

PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors

(2012) F. Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Both G3BP1 and G3BP2 contribute to stress granule formation

(2012) Hideaki Matsuki et al.   GENES TO CELLS

Generation of Multiple Classes of V0 Neurons in Zebrafish Spinal Cord: Progenitor Heterogeneity and Temporal Control of Neuronal Diversity

(2012) C. Satou et al.   JOURNAL OF NEUROSCIENCE

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Phosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation

(2011) Xiao-Nan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine methylation of G3BP1 in response to Wnt3a regulates  -catenin mRNA

(2011) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Revisiting G3BP1 as a RasGAP Binding Protein: Sensitization of Tumor Cells to Chemotherapy by the RasGAP 317–326 Sequence Does Not Involve G3BP1

(2011) Alessandro Annibaldi et al.   PLoS One

Circuit Neuroscience in Zebrafish

(2010) Rainer W. Friedrich et al.   CURRENT BIOLOGY

Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin

(2010) S.-H. Kim et al.   Disease Models & Mechanisms

Tuberous sclerosis complex: tumors and tumorigenesis

(2010) Julita Borkowska et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions

(2009) Jun Chu et al.   BIOSENSORS & BIOELECTRONICS

BLAST+: architecture and applications

(2009) Christiam Camacho et al.   BMC BIOINFORMATICS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Management of epilepsy in tuberous sclerosis complex

(2008) P Curatolo et al.   Expert Review of Neurotherapeutics

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY