Breathing new life into the rational design of Alzheimer’s therapeutics

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

(2020) Guanghui Yang et al.   CELL

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

(2016) Akio Fukumori et al.   EMBO JOURNAL

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Targeting Prodromal Alzheimer Disease With Avagacestat

(2015) Vladimir Coric et al.   JAMA Neurology

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

(2008) Daniel Dries et al.   Current Alzheimer Research